In EDS ansehen

Atherogenic and Inflammatory Markers in Recent Small Subcortical Infarcts: Associations with Location, Morphology, and Short-Term Recurrence

Gespeichert in:
Bibliographische Detailangaben
Titel: Atherogenic and Inflammatory Markers in Recent Small Subcortical Infarcts: Associations with Location, Morphology, and Short-Term Recurrence
Autoren: Chaojuan Huang, Jie Geng, Jie Fan, Bo Tian, Kaigui Wang, Yimei Zhang, Xia Zhou, Xiaoqun Zhu, Zhongwu Sun
Quelle: J Inflamm Res
Journal of Inflammation Research, Vol Volume 18, Iss Issue 1, Pp 5881-5893 (2025)
Verlagsinformationen: Informa UK Limited, 2025.
Publikationsjahr: 2025
Schlagwörter: recurrence, cerebral small vessel disease, systemic immune-inflammation index, recent small subcortical infarct, Pathology, systemic inflammation response index, RB1-214, atherogenic index of plasma, Therapeutics. Pharmacology, RM1-950, Original Research
Beschreibung: Recent small subcortical infarcts (RSSIs) have emerged as a growing public health concern due to their poor long-term clinical outcomes. This study aimed to investigate the associations between the atherogenic index of plasma (AIP), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) with the occurrence and recurrence of RSSIs.Three hundred forty-two patients with RSSIs who met the eligibility criteria were included in the cross-sectional analysis. Comprehensive demographic, laboratory, and neuroimaging data were collected at baseline. Patients were categorized into subcortical white matter, basal ganglia, and brainstem RSSIs based on lesion location. Lesions were further classified by shape (round/oval or tubular) and diameter (≤15 mm or >15 mm). Of these, 336 patients completed follow-up at six months. Logistic regression models were established to assess the relationships between AIP, SII, and SIRI with the occurrence and recurrence of RSSIs, considering variations in lesion location and morphology. The short-term prognostic performances of individual and combined risk factors were evaluated using receiver operating characteristic curve analysis.Cross-sectional analysis revealed a significant positive correlation between AIP and basal ganglia RSSIs (OR: 3.269, 95% CI: 1.209-8.839), as well as between SIRI and brainstem RSSIs (OR: 1.472, 95% CI: 1.012-2.143) and tubular RSSIs (OR: 1.440, 95% CI: 1.043-1.989), after adjusting for potential confounders. In the longitudinal analysis, multivariate regression indicated that hypertension, periventricular white matter hyperintensities, and SII were independently associated with RSSI recurrence. The predictive model demonstrated strong performance, with an area under the curve of 0.853 (95% CI: 0.738-0.968), sensitivity of 90.9%, and specificity of 75.4%.Atherogenic and inflammatory markers are associated with specific locations and morphologies of RSSIs and serve as potential predictive factors for short-term RSSI recurrence. These findings may enhance our understanding of the mechanisms underlying RSSIs and inform early prevention strategies.
Publikationsart: Article
Other literature type
Sprache: English
ISSN: 1178-7031
DOI: 10.2147/jir.s511651
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40331158
https://doaj.org/article/5187e95bcf9b4ee0a2d73e7cc63eb35f
Rights: CC BY NC
URL: http://creativecommons.org/licenses/by-nc/4.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at http://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0/ (http://creativecommons.org/licenses/by-nc/4.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (http://www.dovepress.com/terms.php).
Dokumentencode: edsair.doi.dedup.....bed7da06b8eaa3214592fc685cbe8f35
Datenbank: OpenAIRE
Beschreibung
Abstract:Recent small subcortical infarcts (RSSIs) have emerged as a growing public health concern due to their poor long-term clinical outcomes. This study aimed to investigate the associations between the atherogenic index of plasma (AIP), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) with the occurrence and recurrence of RSSIs.Three hundred forty-two patients with RSSIs who met the eligibility criteria were included in the cross-sectional analysis. Comprehensive demographic, laboratory, and neuroimaging data were collected at baseline. Patients were categorized into subcortical white matter, basal ganglia, and brainstem RSSIs based on lesion location. Lesions were further classified by shape (round/oval or tubular) and diameter (≤15 mm or >15 mm). Of these, 336 patients completed follow-up at six months. Logistic regression models were established to assess the relationships between AIP, SII, and SIRI with the occurrence and recurrence of RSSIs, considering variations in lesion location and morphology. The short-term prognostic performances of individual and combined risk factors were evaluated using receiver operating characteristic curve analysis.Cross-sectional analysis revealed a significant positive correlation between AIP and basal ganglia RSSIs (OR: 3.269, 95% CI: 1.209-8.839), as well as between SIRI and brainstem RSSIs (OR: 1.472, 95% CI: 1.012-2.143) and tubular RSSIs (OR: 1.440, 95% CI: 1.043-1.989), after adjusting for potential confounders. In the longitudinal analysis, multivariate regression indicated that hypertension, periventricular white matter hyperintensities, and SII were independently associated with RSSI recurrence. The predictive model demonstrated strong performance, with an area under the curve of 0.853 (95% CI: 0.738-0.968), sensitivity of 90.9%, and specificity of 75.4%.Atherogenic and inflammatory markers are associated with specific locations and morphologies of RSSIs and serve as potential predictive factors for short-term RSSI recurrence. These findings may enhance our understanding of the mechanisms underlying RSSIs and inform early prevention strategies.
ISSN:11787031
DOI:10.2147/jir.s511651