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Antimicrobial activity of ethanolic extract of Hunteria umbellata seeds on selected clinical isolates

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Title: Antimicrobial activity of ethanolic extract of Hunteria umbellata seeds on selected clinical isolates
Authors: Uka, Emmanuel, Nelson, Violet Akwo, Fatunla, Opeyemi K., Udosen, Christiana Ime, Ugor, Mcvin Akpa
Source: GSC Biological and Pharmaceutical Sciences. 32:203-214
Publisher Information: GSC Online Press, 2025.
Publication Year: 2025
Subject Terms: Clinical isolates, Zone of inhibition, Antimicrobial activity, Hunteria umbellata seeds, Minimum Inhibitory Concentration (MIC), Natural antimicrobial agents
Description: Hunteria umbellata, a medicinal plant widely used in African ethnomedicine, is reputed for its broad pharmacological properties. This study investigated the antimicrobial activity of ethanolic extract of Hunteria umbellata seeds (EEHUS) against selected clinical isolates, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Streptococcus spp., Enterobacter spp., Candida albicans, and Aspergillus niger. The antimicrobial efficacy was determined using agar well diffusion assays, minimum inhibitory concentration (MIC), and minimum bactericidal/fungicidal concentration (MBC/MFC) analyses. Results revealed notable antibacterial activity, with Escherichia coli, Streptococcus spp., and Enterobacter spp. exhibiting high susceptibility (MIC = 100 mg/mL), while Salmonella spp., Pseudomonas aeruginosa, and Vibrio cholerae showed reduced sensitivity (MIC = 200 mg/mL). EEHUS also demonstrated promising antifungal potential, particularly against Candida albicans (MIC = 100 mg/mL, MFC = 150 mg/mL) and Aspergillus niger (MIC = 200 mg/mL, MFC = 300 mg/mL), though Mucor spp. exhibited complete resistance. The findings support the antimicrobial potential of Hunteria umbellata seed extract and validates its traditional usage. However, its limited activity against resistant strains suggests the need for phytochemical optimization and further pharmacological evaluation.
Document Type: Article
ISSN: 2581-3250
DOI: 10.30574/gscbps.2025.32.1.0247
DOI: 10.5281/zenodo.16981868
DOI: 10.5281/zenodo.16981870
Rights: CC BY
Accession Number: edsair.doi.dedup.....be40b4c69488eaea6ccf1437c63c8170
Database: OpenAIRE
Description
Abstract:Hunteria umbellata, a medicinal plant widely used in African ethnomedicine, is reputed for its broad pharmacological properties. This study investigated the antimicrobial activity of ethanolic extract of Hunteria umbellata seeds (EEHUS) against selected clinical isolates, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Streptococcus spp., Enterobacter spp., Candida albicans, and Aspergillus niger. The antimicrobial efficacy was determined using agar well diffusion assays, minimum inhibitory concentration (MIC), and minimum bactericidal/fungicidal concentration (MBC/MFC) analyses. Results revealed notable antibacterial activity, with Escherichia coli, Streptococcus spp., and Enterobacter spp. exhibiting high susceptibility (MIC = 100 mg/mL), while Salmonella spp., Pseudomonas aeruginosa, and Vibrio cholerae showed reduced sensitivity (MIC = 200 mg/mL). EEHUS also demonstrated promising antifungal potential, particularly against Candida albicans (MIC = 100 mg/mL, MFC = 150 mg/mL) and Aspergillus niger (MIC = 200 mg/mL, MFC = 300 mg/mL), though Mucor spp. exhibited complete resistance. The findings support the antimicrobial potential of Hunteria umbellata seed extract and validates its traditional usage. However, its limited activity against resistant strains suggests the need for phytochemical optimization and further pharmacological evaluation.
ISSN:25813250
DOI:10.30574/gscbps.2025.32.1.0247