Association between EPCs count and rate of coronary revascularization in asymptomatic type 2 diabetic patients
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| Titel: | Association between EPCs count and rate of coronary revascularization in asymptomatic type 2 diabetic patients |
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| Autoren: | Min Kyung Chae, Eun Seok Kang, Hye Jeong Lee, Hyun Chul Lee, Kwang Joon Kim, Bong Soo Cha, Young Jin Kim, Hyun Min Kim, Hyuk Jae Chang, Byung Wan Lee, Jae Hoon Moon |
| Weitere Verfasser: | Hyun Min Kim, Kwang Joon Kim, Jae Hoon Moon, Hye-Jeong Lee, Min Kyung Chae, Hyuk-Jae Chang, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Young Jin Kim, Chang, Hyuck Jae, Cha, Bong Soo, Chae, Min Kyung, Kang, Eun Seok, Kim, Young Jin, Kim, Hyun Min, Moon, Jae Hoon, Lee, Byung Wan, Lee, Hyun Chul, Lee, Hye Jeong, Kim, Kwang Joon |
| Quelle: | Acta Diabetologica. 49:413-420 |
| Verlagsinformationen: | Springer Science and Business Media LLC, 2011. |
| Publikationsjahr: | 2011 |
| Schlagwörter: | Adult, Male, Asymptomatic Diseases/epidemiology, Stem Cells/pathology, Cell Count, Coronary Artery Disease, Coronary Angiography, Type 2/epidemiology, Coronary artery disease, Myocardial Revascularization/statistics & numerical data, Diabetic Angiopathies/epidemiology, Endothelial Cells/pathology, 03 medical and health sciences, Coronary Artery Disease/etiology, 0302 clinical medicine, Type 2 diabetes mellitus, Coronary Artery Disease/epidemiology, Diabetes Mellitus, Myocardial Revascularization, Humans, Coronary Artery Disease/surgery, Type 2/pathology, Endothelial progenitor cells, Aged, Revascularization, Stem Cells, Endothelial Cells, Middle Aged, Type 2/complications, 3. Good health, Diabetes Mellitus, Type 2, Case-Control Studies, Diabetic Angiopathies/surgery, Asymptomatic Diseases, Cardiovascular magnetic resonance, Female, Type 2/surgery, Diabetic Angiopathies |
| Beschreibung: | Coronary arterial disease (CAD) is common in diabetic patients, and endothelial progenitor cells (EPCs) are considered a surrogate marker for CAD, but controversies regarding this issue still remain. We investigated the potential clinical role of EPCs during coronary screening in asymptomatic type 2 diabetic patients screened with cardiovascular magnetic resonance (CMR). A total of 100 asymptomatic type 2 diabetic subjects (51 men and 49 women) were enrolled. Clinical and laboratory parameters, including EPCs (CD34(+)/CD133(+)/VEGFR-2(+)) count, were evaluated and CMR was performed. A total of 51 patients [silent myocardial infarction (n = 3), inducible ischemia (n = 11), suspected CAD (n = 37)] had abnormal finding on CMR. Of the 20 patients who later underwent invasive coronary angiography, 8 were treated with revascularization. Fifty-one subjects with abnormal finding on CMR were divided into two groups [subjects with revascularization (group I, n = 8) vs. without revascularization (group II, n = 43)]. Group I had a significantly increased EPCs level than group II (833 vs. 415, P = 0.027). Multivariate logistic regression analysis revealed that an increased EPCs level (OR = 1.003, P = 0.024) and a high body-mass index (OR = 1.907, P = 0.028) were independently correlated with revascularization. In our study, increased EPCs count is associated with performing revascularization in asymptomatic type 2 diabetic patients, and that increased EPCs count can provide clinically important information while performing intervention. |
| Publikationsart: | Article |
| Sprache: | English |
| ISSN: | 1432-5233 0940-5429 |
| DOI: | 10.1007/s00592-011-0360-3 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/22160247 https://link.springer.com/article/10.1007%2Fs00592-011-0360-3 https://ir.ymlib.yonsei.ac.kr/handle/22282913/89358 https://yonsei.pure.elsevier.com/en/publications/association-between-epcs-count-and-rate-of-coronary-revasculariza https://www.ncbi.nlm.nih.gov/pubmed/22160247 https://mdanderson.elsevierpure.com/en/publications/association-between-epcs-count-and-rate-of-coronary-revasculariza |
| Rights: | Springer TDM CC BY NC ND |
| Dokumentencode: | edsair.doi.dedup.....bdf73b01b69e2e16953d3439a567deb8 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Coronary arterial disease (CAD) is common in diabetic patients, and endothelial progenitor cells (EPCs) are considered a surrogate marker for CAD, but controversies regarding this issue still remain. We investigated the potential clinical role of EPCs during coronary screening in asymptomatic type 2 diabetic patients screened with cardiovascular magnetic resonance (CMR). A total of 100 asymptomatic type 2 diabetic subjects (51 men and 49 women) were enrolled. Clinical and laboratory parameters, including EPCs (CD34(+)/CD133(+)/VEGFR-2(+)) count, were evaluated and CMR was performed. A total of 51 patients [silent myocardial infarction (n = 3), inducible ischemia (n = 11), suspected CAD (n = 37)] had abnormal finding on CMR. Of the 20 patients who later underwent invasive coronary angiography, 8 were treated with revascularization. Fifty-one subjects with abnormal finding on CMR were divided into two groups [subjects with revascularization (group I, n = 8) vs. without revascularization (group II, n = 43)]. Group I had a significantly increased EPCs level than group II (833 vs. 415, P = 0.027). Multivariate logistic regression analysis revealed that an increased EPCs level (OR = 1.003, P = 0.024) and a high body-mass index (OR = 1.907, P = 0.028) were independently correlated with revascularization. In our study, increased EPCs count is associated with performing revascularization in asymptomatic type 2 diabetic patients, and that increased EPCs count can provide clinically important information while performing intervention. |
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| ISSN: | 14325233 09405429 |
| DOI: | 10.1007/s00592-011-0360-3 |