Induced Periodontitis in Rats With Three Ligature Types: An Exploratory Study
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| Title: | Induced Periodontitis in Rats With Three Ligature Types: An Exploratory Study |
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| Authors: | Chatzaki, Natalia, Stavropoulos, Andreas, Denes, Balazs Jozsef, Cancela, José Antonio, Kiliaridis, Stavros, Giannopoulou, Catherine |
| Source: | Clin Exp Dent Res Clinical and Experimental Dental Research, Vol 10, Iss 4, Pp n/a-n/a (2024) Chatzaki, Natalia; Stavropoulos, Andreas; Denes, Balazs; Cancela, José; Kiliaridis, Stavros; Giannopoulou, Catherine (2024). Induced Periodontitis in Rats With Three Ligature Types: An Exploratory Study. Clinical and experimental dental research, 10(4), e946. Wiley 10.1002/cre2.946 <http://dx.doi.org/10.1002/cre2.946> |
| Publisher Information: | Wiley, 2024. |
| Publication Year: | 2024 |
| Subject Terms: | Male, 617.6, Alveolar Bone Loss / etiology, Alveolar Bone Loss, 610 Medicine & health, Odontologi, metal wire, Orthodontic Wires, Animals, Rats, Wistar, Periodontitis, Ligation, Ligatures, experimental periodontitis, Experimental periodontitis, Periodontitis / pathology, RK1-715, X-Ray Microtomography, Molar, Rats, ligatures, rats, Disease Models, Animal, Dentistry, Alveolar Bone Loss / pathology, Original Article, Metal wire |
| Description: | BackgroundThe placement of ligatures in the cervical area of rat molars is considered as a predictable model to induce periodontitis.ObjectivesThe present explorative study aimed to compare the efficacy of metal wires (MWs), without or with sandblasting, versus silk ligatures (SLs) in inducing periodontal bone loss in rats.Materials and MethodsTwenty‐four Wistar rats were randomly divided into three groups of eight rats that received three different types of ligatures (MW, sandblasted wire [SMW], and SL) around their first right mandibular molar, while the contralateral tooth was left without the ligature and served as a control. Bone loss was assessed by measuring the distance from the cementoenamel junction (CEJ) to the bone crest at the distal aspect of the first molar on central mesiodistal sections generated from micro‐CT scans taken 24 and 35 days after ligature placement.ResultsIn the SL group, only in two rats the ligatures were retained until the end of the 24‐day period; in all other animals, the ligatures were lost at some time point. In the SMW, the ligatures were retained only for the 24‐day period. In the MW group, no ligatures were lost. Irrespective of the group or experimental period, the difference in the crestal bone level between ligated and control teeth was in most cases z ConclusionsBone loss was minimal during the experimental period, with no significant differences between the test and control teeth, or among the three types of ligatures. MWs, not even roughened, do not seem to be a better alternative to SLs for inducing bone loss in the experimental periodontitis model in the rat. This assumption, however, has to be confirmed in a larger, well‐powered study. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 2057-4347 |
| DOI: | 10.1002/cre2.946 |
| DOI: | 10.48350/199529 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/39104140 https://doaj.org/article/a53252ff6e9349fb8a15818c76851293 https://boris.unibe.ch/199529/ http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-70408 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....bd8b77b068e76dc4532b0aa67b404ccf |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | BackgroundThe placement of ligatures in the cervical area of rat molars is considered as a predictable model to induce periodontitis.ObjectivesThe present explorative study aimed to compare the efficacy of metal wires (MWs), without or with sandblasting, versus silk ligatures (SLs) in inducing periodontal bone loss in rats.Materials and MethodsTwenty‐four Wistar rats were randomly divided into three groups of eight rats that received three different types of ligatures (MW, sandblasted wire [SMW], and SL) around their first right mandibular molar, while the contralateral tooth was left without the ligature and served as a control. Bone loss was assessed by measuring the distance from the cementoenamel junction (CEJ) to the bone crest at the distal aspect of the first molar on central mesiodistal sections generated from micro‐CT scans taken 24 and 35 days after ligature placement.ResultsIn the SL group, only in two rats the ligatures were retained until the end of the 24‐day period; in all other animals, the ligatures were lost at some time point. In the SMW, the ligatures were retained only for the 24‐day period. In the MW group, no ligatures were lost. Irrespective of the group or experimental period, the difference in the crestal bone level between ligated and control teeth was in most cases z ConclusionsBone loss was minimal during the experimental period, with no significant differences between the test and control teeth, or among the three types of ligatures. MWs, not even roughened, do not seem to be a better alternative to SLs for inducing bone loss in the experimental periodontitis model in the rat. This assumption, however, has to be confirmed in a larger, well‐powered study. |
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| ISSN: | 20574347 |
| DOI: | 10.1002/cre2.946 |