In EDS ansehen

Do you know what I’m thinking? Temporal and spatial brain activity during a theory-of-mind task in children with autism

Gespeichert in:
Bibliographische Detailangaben
Titel: Do you know what I’m thinking? Temporal and spatial brain activity during a theory-of-mind task in children with autism
Autoren: Veronica Yuk, Charline Urbain, Elizabeth W. Pang, Evdokia Anagnostou, Daphna Buchsbaum, Margot J. Taylor
Quelle: Dev Cogn Neurosci
Developmental Cognitive Neuroscience, Vol 34, Iss, Pp 139-147 (2018)
Developmental cognitive neuroscience, 34
Verlagsinformationen: Elsevier BV, 2018.
Publikationsjahr: 2018
Schlagwörter: Neurophysiology and neuropsychology, Male, Executive Function -- physiology, Autism Spectrum Disorder, Autism, False belief, Magnetoencephalography -- methods, Theory of Mind, Theory of Mind -- physiology, Temporal Lobe -- physiopathology, Executive Function, 03 medical and health sciences, Spatial Processing, 0302 clinical medicine, Humans, 0501 psychology and cognitive sciences, Spatial Processing -- physiology, Child, Children, Original Research, QP351-495, 05 social sciences, Brain -- physiopathology, Brain, Magnetoencephalography, Sciences bio-médicales et agricoles, Temporal Lobe, 3. Good health, Theory of mind, Female, Autism Spectrum Disorder -- genetics -- pathology
Beschreibung: The social impairments observed in children with autism spectrum disorder are thought to arise in part from deficits in theory of mind, the ability to understand other people's thoughts and feelings. To determine the temporal-spatial dynamics of brain activity underlying these atypical theory-of-mind processes, we used magnetoencephalography to characterize the sequence of functional brain patterns (i.e. when and where) related to theory-of-mind reasoning in 19 high-functioning children with autism compared to 22 age- and sex-matched typically-developing children aged 8-12 during a false-belief (theory-of-mind) task. While task performance did not differ between the two groups, children with autism showed reduced activation in the left temporoparietal junction between 300-375 and 425-500 ms, as well as increased activation in the right inferior frontal gyrus from 325 to 375 ms compared to controls. The overlap in decreased temporoparietal junction activity and increased right inferior frontal gyrus activation from 325 to 375 ms suggests that in children with autism, the right inferior frontal gyrus may compensate for deficits in the temporoparietal junction, a neural theory-of-mind network hub. As the right inferior frontal gyrus is involved in inhibitory control, this finding suggests that children with autism rely on executive functions to bolster their false-belief understanding.
Publikationsart: Article
Other literature type
Dateibeschreibung: 2 full-text file(s): application/pdf; application/pdf
Sprache: English
ISSN: 1878-9293
DOI: 10.1016/j.dcn.2018.08.001
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/30415185
https://doaj.org/article/a4f7b41ac251499da23faca4c96b4bb7
https://pubmed.ncbi.nlm.nih.gov/30415185/
https://www.ncbi.nlm.nih.gov/pubmed/30415185
https://www.sciencedirect.com/science/article/pii/S1878929317301299
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/297542/Holdings
https://www.sciencedirect.com/science/article/abs/pii/S1878929317301299#!
https://europepmc.org/article/MED/30415185
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/297542
Rights: CC BY NC ND
Dokumentencode: edsair.doi.dedup.....bc9296e52c4d16c9600dec88a9703ce5
Datenbank: OpenAIRE
Beschreibung
Abstract:The social impairments observed in children with autism spectrum disorder are thought to arise in part from deficits in theory of mind, the ability to understand other people's thoughts and feelings. To determine the temporal-spatial dynamics of brain activity underlying these atypical theory-of-mind processes, we used magnetoencephalography to characterize the sequence of functional brain patterns (i.e. when and where) related to theory-of-mind reasoning in 19 high-functioning children with autism compared to 22 age- and sex-matched typically-developing children aged 8-12 during a false-belief (theory-of-mind) task. While task performance did not differ between the two groups, children with autism showed reduced activation in the left temporoparietal junction between 300-375 and 425-500 ms, as well as increased activation in the right inferior frontal gyrus from 325 to 375 ms compared to controls. The overlap in decreased temporoparietal junction activity and increased right inferior frontal gyrus activation from 325 to 375 ms suggests that in children with autism, the right inferior frontal gyrus may compensate for deficits in the temporoparietal junction, a neural theory-of-mind network hub. As the right inferior frontal gyrus is involved in inhibitory control, this finding suggests that children with autism rely on executive functions to bolster their false-belief understanding.
ISSN:18789293
DOI:10.1016/j.dcn.2018.08.001