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Altered fatty acid pattern of phospholipids and triglycerides in the submandibular gland of ω3‐depleted rats

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Title: Altered fatty acid pattern of phospholipids and triglycerides in the submandibular gland of ω3‐depleted rats
Authors: Delporte, Christine, Malaisse, Willy, Jurysta, Cédric, Portois, Laurence, Sener, Abdullah, Carpentier, Yvon
Source: European Journal of Oral Sciences. 115:103-110
Publisher Information: Wiley, 2007.
Publication Year: 2007
Subject Terms: 0301 basic medicine, Omega-3 -- biosynthesis, Submandibular gland, Aging, 0303 health sciences, Phospholipids -- analysis, Fatty Acids, Submandibular Gland, Fatty Acids -- analysis, Triglycerides -- analysis, Phospholipid and triglyceride fatty acid pattern, Sciences bio-médicales et agricoles, Aging -- physiology, Rats, 03 medical and health sciences, Fatty Acids, Omega-3, Animals, Female, Long-chain polyunsaturated ω3 fatty acid-depleted rats, Phospholipids, Triglycerides, Submandibular Gland -- chemistry
Description: Alteration of the phospholipid (PL) and triglyceride (TG) fatty acid pattern was recently documented in several organs of rats depleted in long‐chain polyunsaturated ω3 fatty acid (ω3 rats). This study extends such a knowledge to the submandibular gland. The total PL and TG content of the salivary gland was not different in control and ω3 rats. The sole ω3 fatty acids found in ω3 rats (C22:5ω3 and C22:6ω3) were present at levels 3–12 times lower than in control rats. The C22:5ω3/C22:6ω3 ratio was increased threefold in ω3 rats. The PL and TG C16:0/C16:1ω7 and C18:0/C18:1ω9 ratios were decreased in ω3 rats. The conversion of C18:2ω6 to C20:4ω6 and C22:4ω6 appeared facilitated in the ω3 rats. Some of these rats were injected intravenously, 60–120 min before killing, with either a medium‐chain triglyceride:fish oil emulsion or a control medium‐chain triglyceride:olive oil emulsion. The former emulsion increased the PL C22:5ω3 and C22:6ω3 content and prevented the age‐related decrease in C16:0/C16:1ω7 and C18:0/C18:1ω9 ratios otherwise also recorded in PL. In conclusion, these findings document an increased activity of Δ9‐desaturase, a more efficient conversion of C18:2ω6 to its metabolites, and an impaired generation of C22:6ω3 from C22:5ω3 in ω3 rats.
Document Type: Article
File Description: 2 full-text file(s): application/pdf; application/pdf
Language: English
ISSN: 1600-0722
0909-8836
DOI: 10.1111/j.1600-0722.2007.00427.x
Access URL: https://pubmed.ncbi.nlm.nih.gov/17451499
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0722.2007.00427.x
https://www.ncbi.nlm.nih.gov/pubmed/17451499
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/57191/Details
Rights: Wiley Online Library User Agreement
Accession Number: edsair.doi.dedup.....bbac93c1cd65631f0ecf181f878f2ac8
Database: OpenAIRE
Description
Abstract:Alteration of the phospholipid (PL) and triglyceride (TG) fatty acid pattern was recently documented in several organs of rats depleted in long‐chain polyunsaturated ω3 fatty acid (ω3 rats). This study extends such a knowledge to the submandibular gland. The total PL and TG content of the salivary gland was not different in control and ω3 rats. The sole ω3 fatty acids found in ω3 rats (C22:5ω3 and C22:6ω3) were present at levels 3–12 times lower than in control rats. The C22:5ω3/C22:6ω3 ratio was increased threefold in ω3 rats. The PL and TG C16:0/C16:1ω7 and C18:0/C18:1ω9 ratios were decreased in ω3 rats. The conversion of C18:2ω6 to C20:4ω6 and C22:4ω6 appeared facilitated in the ω3 rats. Some of these rats were injected intravenously, 60–120 min before killing, with either a medium‐chain triglyceride:fish oil emulsion or a control medium‐chain triglyceride:olive oil emulsion. The former emulsion increased the PL C22:5ω3 and C22:6ω3 content and prevented the age‐related decrease in C16:0/C16:1ω7 and C18:0/C18:1ω9 ratios otherwise also recorded in PL. In conclusion, these findings document an increased activity of Δ9‐desaturase, a more efficient conversion of C18:2ω6 to its metabolites, and an impaired generation of C22:6ω3 from C22:5ω3 in ω3 rats.
ISSN:16000722
09098836
DOI:10.1111/j.1600-0722.2007.00427.x