Zobrazit v EDS

Conserved aging-related signatures of senescence and inflammation in different tissues and species

Uloženo v:
Podrobná bibliografie
Název: Conserved aging-related signatures of senescence and inflammation in different tissues and species
Autoři: Emanuel Barth, Akash Srivastava, Milan Stojiljkovic, Christiane Frahm, Manja Marz, Otto W. Witte, Hubertus Axer
Zdroj: Aging (Albany NY)
Aging, 11(19):8556-8572
Aging
Informace o vydavateli: Impact Journals, LLC, 2019.
Rok vydání: 2019
Témata: Inflammation, 0301 basic medicine, Aging, 0303 health sciences, Gene Expression Profiling, Longevity, Fishes, Biological Evolution, 3. Good health, Mice, 03 medical and health sciences, Animals, Humans, Aging/immunology [MeSH], Tissue Distribution/genetics, Longevity/immunology, Aging/immunology, Tissue Distribution/genetics [MeSH], Cellular Senescence/genetics, Genetic Association Studies [MeSH], Cellular Senescence/immunology [MeSH], Inflammation/genetics [MeSH], Aging/genetics, Inflammation/genetics, Longevity/genetics, Genetic Association Studies, Cellular Senescence/genetics [MeSH], Aging/genetics [MeSH], Fishes [MeSH], Humans [MeSH], Longevity/genetics [MeSH], Cellular Senescence/immunology, Animals [MeSH], Biomarkers/analysis, Biological Evolution [MeSH], Longevity/immunology [MeSH], Mice [MeSH], Biomarkers/analysis [MeSH], Gene Expression Profiling [MeSH], Tissue Distribution, Biomarkers, Cellular Senescence, Research Paper
Popis: Increasing evidence indicates that chronic inflammation and senescence are the cause of many severe age-related diseases, with both biological processes highly upregulated during aging. However, until now, it has remained unknown whether specific inflammation- or senescence-related genes exist that are common between different species or tissues. These potential markers of aging could help to identify possible targets for therapeutic interventions of aging-associated afflictions and might also deepen our understanding of the principal mechanisms of aging. With the objective of identifying such signatures of aging and tissue-specific aging markers, we analyzed a multitude of cross-sectional RNA-Seq data from four evolutionarily distinct species (human, mouse and two fish) and four different tissues (blood, brain, liver and skin). In at least three different species and three different tissues, we identified several genes that displayed similar expression patterns that might serve as potential aging markers. Additionally, we show that genes involved in aging-related processes tend to be tighter controlled in long-lived than in average-lived individuals. These observations hint at a general genetic level that affect an individual's life span. Altogether, this descriptive study contributes to a better understanding of common aging signatures as well as tissue-specific aging patterns and supplies the basis for further investigative age-related studies.
Druh dokumentu: Article
Conference object
Other literature type
Jazyk: English
ISSN: 1945-4589
DOI: 10.18632/aging.102345
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/31606727
https://europepmc.org/article/PMC/PMC6814591
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814591/
http://www.ncbi.nlm.nih.gov/pubmed/31606727?dopt=Abstract
https://pubmed.ncbi.nlm.nih.gov/31606727/
https://www.aging-us.com/lookup/doi/10.18632/aging.102345
https://repository.publisso.de/resource/frl:6475686
Rights: CC BY
URL: https://creativecommons.org/licenses/by/3.0/deed.en
Přístupové číslo: edsair.doi.dedup.....bb72ef23dea041233fdaf190b1589fb2
Databáze: OpenAIRE
Popis
Abstrakt:Increasing evidence indicates that chronic inflammation and senescence are the cause of many severe age-related diseases, with both biological processes highly upregulated during aging. However, until now, it has remained unknown whether specific inflammation- or senescence-related genes exist that are common between different species or tissues. These potential markers of aging could help to identify possible targets for therapeutic interventions of aging-associated afflictions and might also deepen our understanding of the principal mechanisms of aging. With the objective of identifying such signatures of aging and tissue-specific aging markers, we analyzed a multitude of cross-sectional RNA-Seq data from four evolutionarily distinct species (human, mouse and two fish) and four different tissues (blood, brain, liver and skin). In at least three different species and three different tissues, we identified several genes that displayed similar expression patterns that might serve as potential aging markers. Additionally, we show that genes involved in aging-related processes tend to be tighter controlled in long-lived than in average-lived individuals. These observations hint at a general genetic level that affect an individual's life span. Altogether, this descriptive study contributes to a better understanding of common aging signatures as well as tissue-specific aging patterns and supplies the basis for further investigative age-related studies.
ISSN:19454589
DOI:10.18632/aging.102345