Genomic and genetic insights into Mendel’s pea genes
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| Název: | Genomic and genetic insights into Mendel’s pea genes |
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| Autoři: | Feng, Cong, Chen, Baizhi, Hofer, Julie, Shi, Yan, Jiang, Mei, Song, Bo, Cheng, Hong, Lu, Lu, Wang, Luyao, Howard, Alex, Bendahmane, Abdelhafid, Fouchal, Anissa, Moreau, Carol, Sawada, Chie, Lesignor, Christine, Zhang, Cuijun, Vikeli, Eleni, Tsanakas, Georgios, Zhao, Hang, Cheema, Jitender, Barclay, J, Hou, Junliang, Sayers, Liz, Wingen, Luzie, Vigouroux, Marielle, Vickers, Martin, Ambrose, Mike, Dalmais, Marion, Higuera-Poveda, Paola, Li, Pengfeng, Yuan, Quan, Spanner, Rebecca, Horler, Richard, Wouters, Roland, Chundakkad, Smitha, Wu, Tian, Zhao, Xiaoxiao, Li, Xiuli, Sun, Yuchen, Huang, Zejian, Wu, Zhen, Deng, Xing, Steuernagel, Burkhard, Domoney, Claire, Ellis, Noel, Chayut, Noam, Cheng, Shifeng |
| Přispěvatelé: | Bendahmane, Abdelhafid |
| Zdroj: | Nature |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2025. |
| Rok vydání: | 2025 |
| Témata: | Multidisciplinary, Agriculture & agronomie, [SDV.GEN.GPL] Life Sciences [q-bio]/Genetics/Plants genetics, Sciences du vivant, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Agriculture & agronomy, Life sciences, Article |
| Popis: | Mendel1 studied in detail seven pairs of contrasting traits in pea (Pisum sativum), establishing the foundational principles of genetic inheritance. Here we investigate the genetic architecture that underlies these traits and uncover previously undescribed alleles for the four characterized Mendelian genes2-7, including a rare revertant of Mendel's white-flowered a allele. Primarily, we focus on the three remaining uncharacterized traits and find that (1) an approximately 100-kb genomic deletion upstream of the Chlorophyll synthase (ChlG) gene disrupts chlorophyll biosynthesis through the generation of intergenic transcriptional fusion products, conferring the yellow pod phenotype of gp mutants; (2) a MYB gene with an upstream Ogre element insertion and a CLE peptide-encoding gene with an in-frame premature stop codon explain the v and p alleles, which disrupt secondary cell wall thickening and lignification, resulting in the parchmentless, edible-pod phenotype; and (3) a 5-bp exonic deletion in a CIK-like co-receptor kinase gene, in combination with a genetic modifier locus, is associated with the fasciated stem (fa) phenotype. Furthermore, we characterize genes and alleles associated with diverse agronomic traits, such as axil ring anthocyanin pigmentation, seed size and the 'semi-leafless' form. This study establishes a foundation for fundamental research, education in biology and genetics, and pea breeding practices. |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/s41586-025-08891-6 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/40269167 https://hdl.handle.net/2268/331665 https://doi.org/10.1038/s41586-025-08891-6 https://hal.science/hal-05203828v1 https://doi.org/10.1038/s41586-025-08891-6 https://hal.science/hal-05203828v1/document |
| Rights: | CC BY NC ND |
| Přístupové číslo: | edsair.doi.dedup.....b98d93fb2a7e686fe38c3d4816fde111 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Mendel1 studied in detail seven pairs of contrasting traits in pea (Pisum sativum), establishing the foundational principles of genetic inheritance. Here we investigate the genetic architecture that underlies these traits and uncover previously undescribed alleles for the four characterized Mendelian genes2-7, including a rare revertant of Mendel's white-flowered a allele. Primarily, we focus on the three remaining uncharacterized traits and find that (1) an approximately 100-kb genomic deletion upstream of the Chlorophyll synthase (ChlG) gene disrupts chlorophyll biosynthesis through the generation of intergenic transcriptional fusion products, conferring the yellow pod phenotype of gp mutants; (2) a MYB gene with an upstream Ogre element insertion and a CLE peptide-encoding gene with an in-frame premature stop codon explain the v and p alleles, which disrupt secondary cell wall thickening and lignification, resulting in the parchmentless, edible-pod phenotype; and (3) a 5-bp exonic deletion in a CIK-like co-receptor kinase gene, in combination with a genetic modifier locus, is associated with the fasciated stem (fa) phenotype. Furthermore, we characterize genes and alleles associated with diverse agronomic traits, such as axil ring anthocyanin pigmentation, seed size and the 'semi-leafless' form. This study establishes a foundation for fundamental research, education in biology and genetics, and pea breeding practices. |
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| ISSN: | 14764687 00280836 |
| DOI: | 10.1038/s41586-025-08891-6 |