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Hepatic regeneration is decreased in a rat model of sinusoidal obstruction syndrome

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Titel: Hepatic regeneration is decreased in a rat model of sinusoidal obstruction syndrome
Autoren: Schiffer, Eduardo, Frossard, Jean-Louis, Rubbia-Brandt, Laura, Mentha, Gilles, Pastor, Catherine
Quelle: Journal of Surgical Oncology, Vol. 99, No 7 (2009) pp. 439-446
Journal of surgical oncology
Verlagsinformationen: Wiley, 2009.
Publikationsjahr: 2009
Schlagwörter: Organoplatinum Compounds, Hepatic Veno-Occlusive Disease, Antineoplastic Agents, ddc:616.07, 616.07, ddc:616.0757, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Animals, Hepatectomy, Organoplatinum Compounds/adverse effects, ddc:616, Monocrotaline, ddc:617, 616.0757, Hepatic Veno-Occlusive Disease/chemically induced/*physiopathology/surgery, Colorectal Neoplasms/drug therapy, Antineoplastic Agents/*adverse effects, Liver Regeneration, Rats, 3. Good health, Oxaliplatin, Disease Models, Animal, Colorectal Neoplasms
Beschreibung: Background and ObjectivesOxaliplatin is a chemotherapeutic drug for colorectal adenocarcinoma able to extend the indications for resection of colorectal liver metastases. However, the drug may severely injure hepatic sinusoids, inducing a sinusoidal obstruction syndrome in non‐tumoral parenchyma with a risk of decreased regeneration in the remnant liver following partial hepatectomy.MethodsWe then investigated the evolution of hepatic functions and liver regeneration following partial hepatectomy in rats with sinusoidal obstruction syndrome. The sinusoidal obstruction syndrome was induced with a single intragastric administration of monocrotaline (MCT).ResultsMCT administration induced obstruction of the hepatic microcirculation and increased portal pressure, hepatic VEGF expression, and Ki67 positive hepatocytes. A mild cholestasis was present without modification of hepatic tests. Following a 70% hepatectomy, liver regeneration was significantly impaired by MCT administration and this impaired regeneration was associated with hepatocellular injury evidenced 1 week after hepatectomy.ConclusionsThe presence of sinusoidal obstruction syndrome impairs hepatic regeneration in this rat model of sinusoidal obstruction syndrome. J. Surg. Oncol. 2009;99:439–446. © 2009 Wiley‐Liss, Inc.
Publikationsart: Article
Dateibeschreibung: application/pdf
Sprache: English
ISSN: 1096-9098
0022-4790
DOI: 10.1002/jso.21276
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/19353590
https://onlinelibrary.wiley.com/doi/10.1002/jso.21276
https://core.ac.uk/display/60825822
https://archive-ouverte.unige.ch/unige:20079
http://europepmc.org/abstract/MED/19353590
https://pubmed.ncbi.nlm.nih.gov/19353590/
https://archive-ouverte.unige.ch/unige:20079
Rights: Wiley Online Library User Agreement
Dokumentencode: edsair.doi.dedup.....b8bb0c4f82e9c9749d43522fc20c3f12
Datenbank: OpenAIRE
Beschreibung
Abstract:Background and ObjectivesOxaliplatin is a chemotherapeutic drug for colorectal adenocarcinoma able to extend the indications for resection of colorectal liver metastases. However, the drug may severely injure hepatic sinusoids, inducing a sinusoidal obstruction syndrome in non‐tumoral parenchyma with a risk of decreased regeneration in the remnant liver following partial hepatectomy.MethodsWe then investigated the evolution of hepatic functions and liver regeneration following partial hepatectomy in rats with sinusoidal obstruction syndrome. The sinusoidal obstruction syndrome was induced with a single intragastric administration of monocrotaline (MCT).ResultsMCT administration induced obstruction of the hepatic microcirculation and increased portal pressure, hepatic VEGF expression, and Ki67 positive hepatocytes. A mild cholestasis was present without modification of hepatic tests. Following a 70% hepatectomy, liver regeneration was significantly impaired by MCT administration and this impaired regeneration was associated with hepatocellular injury evidenced 1 week after hepatectomy.ConclusionsThe presence of sinusoidal obstruction syndrome impairs hepatic regeneration in this rat model of sinusoidal obstruction syndrome. J. Surg. Oncol. 2009;99:439–446. © 2009 Wiley‐Liss, Inc.
ISSN:10969098
00224790
DOI:10.1002/jso.21276