Bioplex analysis of plasma cytokines in Alzheimer’s disease and mild cognitive impairment
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| Title: | Bioplex analysis of plasma cytokines in Alzheimer’s disease and mild cognitive impairment |
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| Authors: | Ji Hyung Chung, Byoung Hoon Oh, Min Jeong Shin, Kyung Hye Lee, Kang Soo Lee, Chang Hyung Hong |
| Contributors: | Kang Soo Lee, Ji Hyung Chung, Kyung Hye Lee, Min-Jeong Shin, Byoung Hoon Oh, Chang Hyung Hong, Oh, Byong Hoon |
| Source: | Immunology Letters. 121:105-109 |
| Publisher Information: | Elsevier BV, 2008. |
| Publication Year: | 2008 |
| Subject Terms: | Alzheimer Disease/diagnosis, Cognition Disorders/diagnosis, Male, Polymers, Macrophage Migration-Inhibitory Factors/blood, Chemokine CXCL9/immunology, Enzyme-Linked Immunosorbent Assay, Cognition Disorders/blood, Cognition Disorders/immunology, Cytokines/blood, Chemokine CXCL9, 03 medical and health sciences, Cytokines/immunology, 0302 clinical medicine, Alzheimer Disease/psychology, Alzheimer Disease, 80 and over, Humans, Macrophage Migration-Inhibitory Factors/immunology, Macrophage Migration-Inhibitory Factors, Alzheimer Disease/immunology, Aged, Aged, 80 and over, Gene Expression Regulation/immunology, Cytokines/genetics, Alzheimer Disease/blood, Cognition Disorders/psychology, Intramolecular Oxidoreductases/genetics, Prognosis, 3. Good health, Intramolecular Oxidoreductases, Chemokine CXCL9/genetics, Gene Expression Regulation, Intramolecular Oxidoreductases/immunology, Macrophage Migration-Inhibitory Factors/genetics, Disease Progression, Cytokines, Intramolecular Oxidoreductases/blood, Female, Chemokine CXCL9/blood, Cognition Disorders, Biomarkers/blood, Biomarkers |
| Description: | Inflammatory mechanisms within the central nervous system contribute to cognitive impairment via cytokine-mediated interactions between neurons and glial cells. Sixty-nine subjects were consecutively recruited from October 2005 to February 2007. Fifteen individuals were excluded from the study and we ultimately enrolled 19 not cognitively impaired subjects, 25 mild cognitive impairment patients, and 10 Alzheimer's disease patients. To examine the inflammatory markers of mild cognitive impairment and Alzheimer's disease, we measured the plasma concentrations of 23 cytokines using a bioplex assay. The results showed that the macrophage migration inhibitory factor was higher in mild cognitive impairment and in Alzheimer's disease patients compared with the not cognitively impaired group; the results also showed that monokine induced by gamma interferon was higher in Alzheimer's disease patients than in not cognitively impaired subjects, as well as those of the mild cognitive impairment group [corrected]. |
| Document Type: | Article |
| File Description: | 105~109 |
| Language: | English |
| ISSN: | 0165-2478 |
| DOI: | 10.1016/j.imlet.2008.09.004 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/18930766 https://koreauniv.pure.elsevier.com/en/publications/bioplex-analysis-of-plasma-cytokines-in-alzheimers-disease-and-mi http://repository.ajou.ac.kr/handle/201003/823?mode=simple https://www.sciencedirect.com/science/article/pii/S0165247808002186 https://www.sciencedirect.com/science/article/abs/pii/S0165247808002186#! https://pubmed.ncbi.nlm.nih.gov/18930766/ http://www.sciencedirect.com/science/article/pii/S0165247808002186 |
| Rights: | Elsevier TDM CC BY NC ND |
| Accession Number: | edsair.doi.dedup.....b7a87a0789643f92cb4486cfec4de4ae |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Inflammatory mechanisms within the central nervous system contribute to cognitive impairment via cytokine-mediated interactions between neurons and glial cells. Sixty-nine subjects were consecutively recruited from October 2005 to February 2007. Fifteen individuals were excluded from the study and we ultimately enrolled 19 not cognitively impaired subjects, 25 mild cognitive impairment patients, and 10 Alzheimer's disease patients. To examine the inflammatory markers of mild cognitive impairment and Alzheimer's disease, we measured the plasma concentrations of 23 cytokines using a bioplex assay. The results showed that the macrophage migration inhibitory factor was higher in mild cognitive impairment and in Alzheimer's disease patients compared with the not cognitively impaired group; the results also showed that monokine induced by gamma interferon was higher in Alzheimer's disease patients than in not cognitively impaired subjects, as well as those of the mild cognitive impairment group [corrected]. |
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| ISSN: | 01652478 |
| DOI: | 10.1016/j.imlet.2008.09.004 |