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Pressure control strategies in biosafety level-3 large-scale production facilities for animal vaccines

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Bibliographic Details
Title: Pressure control strategies in biosafety level-3 large-scale production facilities for animal vaccines
Authors: Xin Feng, Yi Li, Lei Liang
Source: Biosafety and Health, Vol 2, Iss 3, Pp 124-129 (2020)
Publisher Information: Elsevier BV, 2020.
Publication Year: 2020
Subject Terms: Working condition conversion, 0211 other engineering and technologies, Infectious and parasitic diseases, RC109-216, 02 engineering and technology, Negative pressure, 01 natural sciences, 3. Good health, Animal vaccine, BSL-3 facility, Public aspects of medicine, RA1-1270, Large scale production, 0105 earth and related environmental sciences
Description: This paper summarized the pressure control methods used in 16 large-scale production facilities in China for vaccines against foot-and-mouth disease virus and highly pathogenic avian influenza virus. We presented the pressure control modes, with their characteristics, of the “constant supply” mode - variable exhaust air volume system and the “constant supply” mode - constant exhaust air volume system. This paper analyzed the influence of common problems (e.g., pressure reference zero drift, positive pressure reversal and failure to restore the original normal working conditions after working condition conversion) on system stability during pressure control in BSL-3 large-scale production facilities and their solutions, providing references for the design and implementation of similar construction projects under the new situation.
Document Type: Article
Other literature type
Language: English
ISSN: 2590-0536
DOI: 10.1016/j.bsheal.2020.08.002
Access URL: https://doaj.org/article/12e3becccfa647d9ab70e466977d42e2
https://www.sciencedirect.com/science/article/pii/S2590053620300860
https://doaj.org/article/12e3becccfa647d9ab70e466977d42e2
Rights: CC BY NC ND
Accession Number: edsair.doi.dedup.....b78df3a720ebea62bfc76011df779a70
Database: OpenAIRE
Description
Abstract:This paper summarized the pressure control methods used in 16 large-scale production facilities in China for vaccines against foot-and-mouth disease virus and highly pathogenic avian influenza virus. We presented the pressure control modes, with their characteristics, of the “constant supply” mode - variable exhaust air volume system and the “constant supply” mode - constant exhaust air volume system. This paper analyzed the influence of common problems (e.g., pressure reference zero drift, positive pressure reversal and failure to restore the original normal working conditions after working condition conversion) on system stability during pressure control in BSL-3 large-scale production facilities and their solutions, providing references for the design and implementation of similar construction projects under the new situation.
ISSN:25900536
DOI:10.1016/j.bsheal.2020.08.002