Surgery of the primary tumor in patients with de novo metastatic breast cancer: a nationwide population-based retrospective cohort study in Belgium: a nationwide population-based retrospective cohort study in Belgium
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| Název: | Surgery of the primary tumor in patients with de novo metastatic breast cancer: a nationwide population-based retrospective cohort study in Belgium: a nationwide population-based retrospective cohort study in Belgium |
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| Autoři: | Mariana Brandão, Diogo Martins-Branco, Claudia De Angelis, Peter Vuylsteke, Richard D. Gelber, Nancy Van Damme, Lien van Walle, Arlindo R. Ferreira, Matteo Lambertini, Francesca Poggio, Didier Verhoeven, Annelore Barbeaux, Francois P. Duhoux, Hans Wildiers, Carmela Caballero, Ahmad Awada, Martine Piccart-Gebhart, Kevin Punie, Evandro de Azambuja |
| Přispěvatelé: | UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (MGD) Service d'oncologie médicale, UCL - (SLuc) Service d'oncologie médicale |
| Zdroj: | Breast cancer research and treatment, Vol. 203, no. 2, p. 351-363 (2024) Breast cancer research and treatment |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2023. |
| Rok vydání: | 2023 |
| Témata: | Breast Neoplasms, Triple Negative Breast Neoplasms, Survival analysis, Prognosis, 3. Good health, Cancérologie, Belgium, Humans, Surgery, Female, Human medicine, Registries, Breast neoplasms, Neoplasm Staging, Retrospective Studies |
| Popis: | We aimed to assess the impact of surgery of primary tumor in overall survival (OS) of women with de novo metastatic breast cancer.Nationwide, population-based retrospective cohort study of women diagnosed with de novo metastatic breast cancer in Belgium, between Jan/2010-Dec/2014. Data was obtained from the Belgian Cancer Registry and administrative databases. "Surgery" group was defined by surgery of primary tumor up to nine months after diagnosis. We excluded women who did not receive systemic treatment or did not complete nine months follow-up after diagnosis. All the subsequent analyses reporting on overall survival and the stratified outcome analyses were performed based on this nine-month landmark cohort. OS was estimated using Kaplan-Meier method and compared using adjusted Cox proportional hazards models controlling for confounders with 95% confidence intervals (CI). We performed a stratified analysis according to surgery timing and a propensity score matching analysis.1985 patients, 534 (26.9%) in the "Surgery" and 1451 (73.1%) in the "No Surgery" group. Patients undergoing surgery were younger (p |
| Druh dokumentu: | Article |
| Popis souboru: | 1 full-text file(s): application/pdf |
| Jazyk: | English |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-023-07116-6 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/37878152 https://hdl.handle.net/2078.1/279835 https://hdl.handle.net/10067/2012010151162165141 |
| Rights: | Springer Nature TDM |
| Přístupové číslo: | edsair.doi.dedup.....b73bf5b9e7745577a2fe0d0b65cc1bf3 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | We aimed to assess the impact of surgery of primary tumor in overall survival (OS) of women with de novo metastatic breast cancer.Nationwide, population-based retrospective cohort study of women diagnosed with de novo metastatic breast cancer in Belgium, between Jan/2010-Dec/2014. Data was obtained from the Belgian Cancer Registry and administrative databases. "Surgery" group was defined by surgery of primary tumor up to nine months after diagnosis. We excluded women who did not receive systemic treatment or did not complete nine months follow-up after diagnosis. All the subsequent analyses reporting on overall survival and the stratified outcome analyses were performed based on this nine-month landmark cohort. OS was estimated using Kaplan-Meier method and compared using adjusted Cox proportional hazards models controlling for confounders with 95% confidence intervals (CI). We performed a stratified analysis according to surgery timing and a propensity score matching analysis.1985 patients, 534 (26.9%) in the "Surgery" and 1451 (73.1%) in the "No Surgery" group. Patients undergoing surgery were younger (p |
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| ISSN: | 15737217 01676806 |
| DOI: | 10.1007/s10549-023-07116-6 |