Tetracycline photolysis in natural waters: Loss of antibacterial activity
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| Title: | Tetracycline photolysis in natural waters: Loss of antibacterial activity |
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| Authors: | Wammer, Kristine H., Slattery, Matthew T., Stemig, Amanda, Ditty, Jayna L. |
| Source: | Chemosphere. 85:1505-1510 |
| Publisher Information: | Elsevier BV, 2011. |
| Publication Year: | 2011 |
| Subject Terms: | microbial sensitivity tests, applied sciences, antibacterial agents, Fresh Water, Microbial Sensitivity Tests, water hardness, anti-bacterial agents - chemistry, 01 natural sciences, growth inhibition, antibacterial activity, tetracycline - chemistry, escherichia coli - drug effects, Escherichia coli, pollution, fresh water - chemistry, tetracycline - pharmacology, Environmental Restoration and Remediation, tetracycline, 0105 earth and related environmental sciences, environmental restoration and remediation, Photolysis, anti-bacterial agents - pharmacology, aliivibrio fischeri - drug effects, Hydrogen-Ion Concentration, Tetracycline, Aliivibrio fischeri, 6. Clean water, Anti-Bacterial Agents, 0104 chemical sciences, hydrogen-ion concentration, photolysis, Sunlight, sunlight, exact sciences and technology |
| Description: | Previous work has shown that tetracycline undergoes direct photolysis in the presence of sunlight, with the decomposition rate highly dependent on conditions such as water hardness and pH. The purpose of this study was to examine the potential long-term significance of photoproducts formed when tetracycline undergoes photodegradation under a range of environmentally relevant conditions. Tetracycline was photolyzed in nine different natural and artificial water samples using simulated sunlight. The pH values of the samples ranged from 5 to 9. Total hardness values (combined Ca(2+) and Mg(2+) concentrations) varied from 30 to 450 ppm. Assays based on growth inhibition of two bacterial strains, Escherichia coli DH5α and Vibrio fischeri, were used to determine the antibacterial activity of tetracycline's photoproducts in these water samples. In all tested conditions, it was determined that the photoproducts retain no significant antibacterial activity; all observed growth inhibition was attributable to residual tetracycline. This suggests that tetracycline photoproducts formed under a wide range of pH and water hardness conditions will not contribute to the selection of antibiotic-resistant bacteria in environmental systems. |
| Document Type: | Article |
| File Description: | text/html |
| Language: | English |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/j.chemosphere.2011.08.051 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/21959143 https://ustbiologypublications.files.wordpress.com/2012/11/wammer-etal-2011.pdf https://pubmed.ncbi.nlm.nih.gov/21959143/ https://www.sciencedirect.com/science/article/pii/S0045653511010186 https://www.ncbi.nlm.nih.gov/pubmed/21959143 https://ui.adsabs.harvard.edu/abs/2011Chmsp..85.1505W/abstract http://europepmc.org/abstract/MED/21959143 |
| Rights: | Elsevier TDM |
| Accession Number: | edsair.doi.dedup.....b688c2d5d126a6aa5733726a0d9ff52a |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Previous work has shown that tetracycline undergoes direct photolysis in the presence of sunlight, with the decomposition rate highly dependent on conditions such as water hardness and pH. The purpose of this study was to examine the potential long-term significance of photoproducts formed when tetracycline undergoes photodegradation under a range of environmentally relevant conditions. Tetracycline was photolyzed in nine different natural and artificial water samples using simulated sunlight. The pH values of the samples ranged from 5 to 9. Total hardness values (combined Ca(2+) and Mg(2+) concentrations) varied from 30 to 450 ppm. Assays based on growth inhibition of two bacterial strains, Escherichia coli DH5α and Vibrio fischeri, were used to determine the antibacterial activity of tetracycline's photoproducts in these water samples. In all tested conditions, it was determined that the photoproducts retain no significant antibacterial activity; all observed growth inhibition was attributable to residual tetracycline. This suggests that tetracycline photoproducts formed under a wide range of pH and water hardness conditions will not contribute to the selection of antibiotic-resistant bacteria in environmental systems. |
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| ISSN: | 00456535 |
| DOI: | 10.1016/j.chemosphere.2011.08.051 |