Body composition and checkpoint inhibitor treatment outcomes in advanced melanoma: a multicenter cohort study
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| Název: | Body composition and checkpoint inhibitor treatment outcomes in advanced melanoma: a multicenter cohort study |
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| Autoři: | Mark Schuiveling, Laurens S Ter Maat, Isabella A J Van Duin, Rik J Verheijden, Max F Troenokarso, Pim Moeskops, Joost J C Verhoeff, Sjoerd G Elias, Wouter A C van Amsterdam, Femke Burgers, Franchette W P J Van den Berkmortel, Marye J Boers-Sonderen, Martijn F Boomsma, Jan Willem De Groot, John B A G Haanen, Geke A P Hospers, Djura Piersma, Gerard Vreugdenhil, Hans M Westgeest, Ellen Kapiteijn, Mariette Labots, Wouter B Veldhuis, Paul J Van Diest, Pim A De Jong, Josien P W Pluim, Tim Leiner, Mitko Veta, Karijn P M Suijkerbuijk |
| Zdroj: | J Natl Cancer Inst Journal of the National Cancer Institute, 117, 6, pp. 1245-1252 Journal of the National Cancer Institute, vol. 117, no. 6, pp. 1245-1252 |
| Informace o vydavateli: | Oxford University Press (OUP), 2025. |
| Rok vydání: | 2025 |
| Témata: | Humans, Melanoma/drug therapy, Melanoma/mortality, Melanoma/pathology, Male, Female, Immune Checkpoint Inhibitors/therapeutic use, Body Composition, Middle Aged, Aged, Body Mass Index, Retrospective Studies, Tomography, X-Ray Computed, Adult, Treatment Outcome, Progression-Free Survival, Aged, 80 and over, Netherlands/epidemiology, Skin Neoplasms/drug therapy, Skin Neoplasms/mortality, Skin Neoplasms/pathology, Intra-Abdominal Fat, Muscle, Skeletal/diagnostic imaging, Subcutaneous Fat, Programmed Cell Death 1 Receptor/antagonists & inhibitors, Medical Oncology - Radboud University Medical Center, Article |
| Popis: | Background The association of body composition with checkpoint inhibitor outcomes in melanoma is a matter of ongoing debate. In this study, we aim to investigate body mass index (BMI) alongside computed tomography (CT)-derived body composition metrics in the largest cohort to date. Methods Patients treated with first-line anti-PD1 ± anti-CTLA4 for advanced melanoma were retrospectively identified from 11 melanoma centers in The Netherlands. From baseline CT scans, 5 body composition metrics were extracted: subcutaneous adipose tissue index, visceral adipose tissue index, skeletal muscle index, density, and gauge. These metrics were correlated in univariable and multivariable Cox proportional hazards analysis with progression-free survival, overall survival, and melanoma-specific survival (PFS, OS, and MSS). Results A total of 1471 eligible patients were included. Median PFS and OS were 9.1 and 38.1 months, respectively. Worse PFS was observed in underweight patients (multivariable hazard ratio [HR] = 1.86, 95% CI = 1.14 to 3.06). Furthermore, prolonged OS was observed in patients with higher skeletal muscle density (multivariable HR = 0.88, 95% CI = 0.81 to 0.97) and gauge (multivariable HR = 0.61, 95% CI = 0.82 to 0.998), whereas higher visceral adipose tissue index was associated with worse OS (multivariable HR = 1.12, 95% CI = 1.04 to 1.22). No association with survival outcomes was found for overweight, obesity, or subcutaneous adipose tissue. Conclusion Our findings suggest that underweight BMI is associated with worse PFS, whereas higher skeletal muscle density and lower visceral adipose tissue index were associated with improved OS. These associations were independent of known prognostic factors, including sex, age, performance status, and extent of disease. No significant association between higher BMI and survival outcomes was observed. |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1460-2105 0027-8874 |
| DOI: | 10.1093/jnci/djaf039 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/39980388 https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/320183 https://doi.org/10.1093/jnci/djaf039 https://repository.ubn.ru.nl//bitstream/handle/2066/320183/320183.pdf https://hdl.handle.net/2066/320183 https://serval.unil.ch/notice/serval:BIB_3415CBA985BE http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_3415CBA985BE8 https://serval.unil.ch/resource/serval:BIB_3415CBA985BE.P001/REF.pdf |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Přístupové číslo: | edsair.doi.dedup.....b60d8226db735adc078eb100dd823b8f |
| Databáze: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Background The association of body composition with checkpoint inhibitor outcomes in melanoma is a matter of ongoing debate. In this study, we aim to investigate body mass index (BMI) alongside computed tomography (CT)-derived body composition metrics in the largest cohort to date. Methods Patients treated with first-line anti-PD1 ± anti-CTLA4 for advanced melanoma were retrospectively identified from 11 melanoma centers in The Netherlands. From baseline CT scans, 5 body composition metrics were extracted: subcutaneous adipose tissue index, visceral adipose tissue index, skeletal muscle index, density, and gauge. These metrics were correlated in univariable and multivariable Cox proportional hazards analysis with progression-free survival, overall survival, and melanoma-specific survival (PFS, OS, and MSS). Results A total of 1471 eligible patients were included. Median PFS and OS were 9.1 and 38.1 months, respectively. Worse PFS was observed in underweight patients (multivariable hazard ratio [HR] = 1.86, 95% CI = 1.14 to 3.06). Furthermore, prolonged OS was observed in patients with higher skeletal muscle density (multivariable HR = 0.88, 95% CI = 0.81 to 0.97) and gauge (multivariable HR = 0.61, 95% CI = 0.82 to 0.998), whereas higher visceral adipose tissue index was associated with worse OS (multivariable HR = 1.12, 95% CI = 1.04 to 1.22). No association with survival outcomes was found for overweight, obesity, or subcutaneous adipose tissue. Conclusion Our findings suggest that underweight BMI is associated with worse PFS, whereas higher skeletal muscle density and lower visceral adipose tissue index were associated with improved OS. These associations were independent of known prognostic factors, including sex, age, performance status, and extent of disease. No significant association between higher BMI and survival outcomes was observed. |
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| ISSN: | 14602105 00278874 |
| DOI: | 10.1093/jnci/djaf039 |