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A multidisciplinary and structured investigation of three suspected clusters of transverse upper limb reduction defects in France

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Titel: A multidisciplinary and structured investigation of three suspected clusters of transverse upper limb reduction defects in France
Autoren: Boudet-Berquier, Julie, Demattei, Christophe, Guldner, Laurence, Gallay, Anne, Manouvrier, Sylvie, Botton, Jérémie, Philippat, Claire, Delva, Fleur, Bloch, Juliette, Semaille, Caroline, Odent, Sylvie, Perthus, Isabelle, Randrianaivo, Hanitra, Babajko, Sylvie, Barjat, Tiphaine, Beneteau, Claire, Brennetot, Naima, Garne, Ester, Haddad, Georges, Hocine, Mounia, Lacroix, Isabelle, Leuraud, Klervi, Mench, Michel, Morris, Joan, Patrier, Sophie, Sartelet, Arnaud, Verloes, Alain, Bonaldi, Christophe, Le Barbier, Mélina, Gagnière, Bertrand, Pépin, Philippe, Ollivier, Ronan, Bitoun, Monique, King, Lisa, Guajardo-Villar, Andrea, Gomes, Eugenia, Desenclos, Jean-Claude, Regnault, Nolwenn, Benachi, Alexandra
Weitere Verfasser: GUITTON, SOPHIE, Santé publique France - French National Public Health Agency Saint-Maurice, France, Laboratoire de Biostatistique, Epidémiologie clinique, Santé Publique Innovation et Méthodologie CHU Nîmes (BESPIM), Hôpital Universitaire Carémeau Nîmes (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Direction santé environnement travail - Santé Publique France (DSET), Santé publique France, Cellule Régionale Pays de la Loire Nantes, France, Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 (RADEME), Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), EPI-PHARE (EPI-PHARE), Caisse nationale d'assurance maladie des travailleurs salariés CNAMTS -Agence nationale de sécurité du médicament et des produits de santé Saint-Denis (ANSM), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Direction des alertes et des vigilances sanitaires (DAVS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou, CEMC-Auvergne, Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Agence Régionale de Santé d'Auvergne, Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Pathologies, imagerie et biothérapies oro-faciales = Orofacial pathologies, imaging and biotherapies (URP 2496), Université Paris Cité (UPCité), Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E), Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôtel-Dieu de Nantes, Hôpitaux de Saint Maurice (HNSM), Lillebaelt Hospital Kolding, Denmark (LH), Centre Hospitalier Simone Veil (CH Simone Veil), Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires (MESuRS), Conservatoire National des Arts et Métiers CNAM (CNAM), Equipe SPHERE (CERPOP), Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (IRSN/PSE-SANTE/SESANE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Biodiversité, Gènes & Communautés (BioGeCo), Université de Bordeaux (UB)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), St George's, University of London, CHU Rouen, Normandie Université (NU), Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich (ULiège), AP-HP Hôpital universitaire Robert-Debré Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Santé publique France Provence-Alpes-Côte d'azur et Corse - Provence-Alps-French Riviera and Corsica Marseille, AP-HP - Hôpital Antoine Béclère Clamart
Quelle: European Journal of Epidemiology. 39:753-771
Verlagsinformationen: Springer Science and Business Media LLC, 2024.
Publikationsjahr: 2024
Schlagwörter: Male, Congenital anomalies, Limb reduction defects, Environment, France/epidemiology, Upper Extremity, Congenital, Spatio-Temporal Analysis, Risk Factors, Humans, Cluster Analysis, Upper Extremity Deformities, Congenital, Child, Upper Extremity Deformities, Infant, Environmental Exposure, 3. Good health, Spatiotemporal analyses, Birth defects, Cluster, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, France, Environmental Exposure/adverse effects
Beschreibung: Between 2019-2021, facing public concern, a scientific expert committee (SEC) reanalysed suspected clusters of transverse upper limb reduction defects (TULRD) in three administrative areas in France, where initial investigations had not identified any risk exposure. We share here the national approach we developed for managing suspicious clusters of the same group of congenital anomalies occurring in several areas.The SEC analysed the medical records of TURLD suspected cases and performed spatiotemporal analyses on confirmed cases. If the cluster was statistically significant and included at least three cases, the SEC reviewed exposures obtained from questionnaires, environmental databases, and a survey among farmers living near to cases' homes concerning their plant product use.After case re-ascertainment, no statistically significant cluster was observed in the first administrative areas. In the second area, a cluster of four children born in two nearby towns over two years was confirmed, but as with the initial investigations, no exposure to a known risk factor explaining the number of cases in excess was identified. In the third area, a cluster including just two cases born the same year in the same town was confirmed.Our experience highlights that in the event of suspicious clusters occurring in different areas of a country, a coordinated and standardised approach should be preferred.
Publikationsart: Article
Sprache: English
ISSN: 1573-7284
0393-2990
DOI: 10.1007/s10654-024-01125-5
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38671254
Rights: Springer Nature TDM
CC BY
Dokumentencode: edsair.doi.dedup.....b5fd8bc69257f58afdf5e399e3f6f85f
Datenbank: OpenAIRE
Beschreibung
Abstract:Between 2019-2021, facing public concern, a scientific expert committee (SEC) reanalysed suspected clusters of transverse upper limb reduction defects (TULRD) in three administrative areas in France, where initial investigations had not identified any risk exposure. We share here the national approach we developed for managing suspicious clusters of the same group of congenital anomalies occurring in several areas.The SEC analysed the medical records of TURLD suspected cases and performed spatiotemporal analyses on confirmed cases. If the cluster was statistically significant and included at least three cases, the SEC reviewed exposures obtained from questionnaires, environmental databases, and a survey among farmers living near to cases' homes concerning their plant product use.After case re-ascertainment, no statistically significant cluster was observed in the first administrative areas. In the second area, a cluster of four children born in two nearby towns over two years was confirmed, but as with the initial investigations, no exposure to a known risk factor explaining the number of cases in excess was identified. In the third area, a cluster including just two cases born the same year in the same town was confirmed.Our experience highlights that in the event of suspicious clusters occurring in different areas of a country, a coordinated and standardised approach should be preferred.
ISSN:15737284
03932990
DOI:10.1007/s10654-024-01125-5