Exercise effects on symptoms of depression and anxiety vary by patient, clinical, and intervention characteristics in cancer survivors: Results from pooled analyses of individual participant data of 26 RCTs: Results from pooled analyses of individual participant data of 26 RCTs
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| Title: | Exercise effects on symptoms of depression and anxiety vary by patient, clinical, and intervention characteristics in cancer survivors: Results from pooled analyses of individual participant data of 26 RCTs: Results from pooled analyses of individual participant data of 26 RCTs |
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| Authors: | Marlou-Floor Kenkhuis, Meike Doorenbos, Isa H. Mast, Neil K. Aaronson, Marc van Beurden, Martin Bohus, Kerry S. Courneya, Amanda J. Daley, Daniel A. Galvão, Martine M. Goedendorp, Wim H. van Harten, Sandi C. Hayes, Anouk E. Hiensch, Melinda L. Irwin, Marie José Kersten, Hans Knoop, Anne M. May, Alex McConnachie, Willem van Mechelen, Nanette Mutrie, Robert U. Newton, Frans Nollet, Hester S. Oldenburg, Martina E. Schmidt, Kathryn H. Schmitz, Karl-Heinz Schulz, Gabe S. Sonke, Karen Steindorf, Martijn M. Stuiver, Dennis R. Taaffe, Lene Thorsen, Miranda J. Velthuis, Joachim Wiskemann, Ilse Mesters, Cornelia M. Ulrich, Jonna K. van Vulpen, Jose A. E. Custers, Laurien M. Buffart |
| Source: | Support Care Cancer Supportive Care in Cancer, 33, 7 Supportive care in cancer |
| Publisher Information: | Springer Science and Business Media LLC, 2025. |
| Publication Year: | 2025 |
| Subject Terms: | Male, Neoplasms/psychology, Adult, Depression, Cancer survivors, Research, Distress, Anxiety/therapy, Moderators, Depression/therapy, Anxiety, Middle Aged, Medical Biosciences - Radboud University Medical Center, Exercise Therapy/methods, Medical Psychology - Radboud University Medical Center, Exercise/psychology, Cancer Survivors/psychology, Humans, Female, Human medicine, Survivors/psychology, Exercise, Randomized Controlled Trials as Topic |
| Description: | Purpose This study aimed to investigate whether socio-demographic, clinical, and intervention-related variables moderate the effects of exercise on depression and anxiety symptoms in cancer survivors. Methods Data from 26 RCTs in the POLARIS database were analyzed using a one-step individual participant data (IPD) meta-analytic approach with linear mixed models to assess exercise effects on depression and anxiety symptoms (z-scores). Interaction terms were added to these models to explore moderators. Results are presented as betas (corresponding to Cohen’s d effect size). Results Albeit statistically significant, exercise demonstrated negligible effects on symptoms of depression (β = − 0.11; 95% CI = − 0.16; − 0.06) and anxiety (β = − 0.07; 95% CI = − 0.12; − 0.02) compared to controls. The effects of exercise interventions on depressive symptoms were larger for patients who were not living with a partner (β = − 0.23; 95% CI = − 0.35; − 0.11), had a low/medium education level (β = − 0.14; 95% CI = − 0.21; − 0.07), and who had moderate-to-severe symptoms of depression at baseline (β = − 0.30; 95% CI = − 0.43; − 0.16). Patients with moderate-to-severe symptoms of depression at baseline combined with those not living with a partner or a low/medium education level yielded the largest effect size through exercise (β = − 0.61; 95% CI = − 0.89; − 0.33 and β = − 0.37; 95% CI = − 0.57; − 0.17, respectively). Effects on anxiety symptoms were larger for patients with moderate-to-severe symptoms of anxiety at baseline (β = − 0.17; 95% CI = − 0.32; − 0.01) compared to those with no-to-mild symptoms. Sex, age, cancer type, BMI, and intervention-related variables did not moderate the exercise effects. Conclusion The findings of this study highlight the heterogeneous response to exercise interventions across various patient subgroups. Patients with moderate-to-severe anxiety or depression, those with a low/medium education, and those not living together with a partner may particularly benefit. |
| Document Type: | Article Other literature type |
| Language: | English |
| ISSN: | 1433-7339 0941-4355 |
| DOI: | 10.1007/s00520-025-09646-9 |
| Access URL: | https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/320748 https://research.rug.nl/en/publications/ca71419a-86be-4312-a770-c7cb1fd98c85 https://hdl.handle.net/11370/ca71419a-86be-4312-a770-c7cb1fd98c85 https://doi.org/10.1007/s00520-025-09646-9 https://cris.maastrichtuniversity.nl/en/publications/eb014b3f-771f-4308-8e8b-a2982fbbfda1 https://doi.org/10.1007/s00520-025-09646-9 https://pure.amsterdamumc.nl/en/publications/80b11c97-19f1-4014-9301-645797f375e0 https://doi.org/10.1007/s00520-025-09646-9 https://hdl.handle.net/2066/320748 https://repository.ubn.ru.nl//bitstream/handle/2066/320748/320748.pdf https://repository.uantwerpen.be/docstore/d:irua:30337 https://hdl.handle.net/10067/2161770151162165141 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....b57e08effc11fd5c734f613bedfdb9f8 |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Purpose This study aimed to investigate whether socio-demographic, clinical, and intervention-related variables moderate the effects of exercise on depression and anxiety symptoms in cancer survivors. Methods Data from 26 RCTs in the POLARIS database were analyzed using a one-step individual participant data (IPD) meta-analytic approach with linear mixed models to assess exercise effects on depression and anxiety symptoms (z-scores). Interaction terms were added to these models to explore moderators. Results are presented as betas (corresponding to Cohen’s d effect size). Results Albeit statistically significant, exercise demonstrated negligible effects on symptoms of depression (β = − 0.11; 95% CI = − 0.16; − 0.06) and anxiety (β = − 0.07; 95% CI = − 0.12; − 0.02) compared to controls. The effects of exercise interventions on depressive symptoms were larger for patients who were not living with a partner (β = − 0.23; 95% CI = − 0.35; − 0.11), had a low/medium education level (β = − 0.14; 95% CI = − 0.21; − 0.07), and who had moderate-to-severe symptoms of depression at baseline (β = − 0.30; 95% CI = − 0.43; − 0.16). Patients with moderate-to-severe symptoms of depression at baseline combined with those not living with a partner or a low/medium education level yielded the largest effect size through exercise (β = − 0.61; 95% CI = − 0.89; − 0.33 and β = − 0.37; 95% CI = − 0.57; − 0.17, respectively). Effects on anxiety symptoms were larger for patients with moderate-to-severe symptoms of anxiety at baseline (β = − 0.17; 95% CI = − 0.32; − 0.01) compared to those with no-to-mild symptoms. Sex, age, cancer type, BMI, and intervention-related variables did not moderate the exercise effects. Conclusion The findings of this study highlight the heterogeneous response to exercise interventions across various patient subgroups. Patients with moderate-to-severe anxiety or depression, those with a low/medium education, and those not living together with a partner may particularly benefit. |
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| ISSN: | 14337339 09414355 |
| DOI: | 10.1007/s00520-025-09646-9 |