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Follow-up of CT-derived airway wall thickness: Correcting for changes in inspiration level improves reliability: Correcting for changes in inspiration level improves reliability

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Title: Follow-up of CT-derived airway wall thickness: Correcting for changes in inspiration level improves reliability: Correcting for changes in inspiration level improves reliability
Authors: Esther Pompe, Eva M. van Rikxoort, Onno M. Mets, Jean-Paul Charbonnier, Jan-Martin Kuhnigk, Harry J. de Koning, Matthijs Oudkerk, Rozemarijn Vliegenthart, Pieter Zanen, Jan-Willem J. Lammers, Bram van Ginneken, Pim A. de Jong, Firdaus A.A. Mohamed Hoesein
Contributors: Arts Assistenten Longziekten, Infection & Immunity, Researchgr. Systems Radiology, Beeldverwerking ISI, Circulatory Health, Arts-assistenten Radiologie, Radiologie, Onderzoek Beeld
Source: European Journal of Radiology, 85, 11, pp. 2008-2013
Publisher Information: Elsevier BV, 2016.
Publication Year: 2016
Subject Terms: Male, COMPUTED-TOMOGRAPHY SCANS, DIMENSIONS, Lung Neoplasms, Time Factors, EMC NIHES-02-65-01, PHENOTYPES, EMPHYSEMA, Lung Neoplasms/diagnostic imaging, OBSTRUCTIVE PULMONARY-DISEASE, Lung/diagnostic imaging, 03 medical and health sciences, 0302 clinical medicine, FLOW LIMITATION, Belgium, Medical Imaging - Radboud University Medical Center, Smoking/adverse effects, Journal Article, COPD PATIENTS, Humans, Tomography, Computed tomography, Lung, Netherlands, Clinical Trials as Topic, Airway wall thickness, Follow-up, Smoking, Total Lung Capacity, Reproducibility of Results, Solitary Pulmonary Nodule, Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences, ASSOCIATION, Middle Aged, Reliability, X-Ray Computed/methods, 3. Good health, Lung volume, Solitary Pulmonary Nodule/diagnostic imaging, Inhalation, VOLUME, Radboudumc 5: Inflammatory diseases RIHS: Radboud Institute for Health Sciences, Tomography, X-Ray Computed, SMOKERS, Follow-Up Studies
Description: Airway wall thickness (AWT) is affected by changes in lung volume. This study evaluated whether correcting AWT on computed tomography (CT) for differences in inspiration level improves measurement agreement, reliability, and power to detect changes over time.Participants of the Dutch-Belgian lung cancer screening trial who underwent 3-month repeat CT for an indeterminate pulmonary nodule were included. AWT on CT was calculated by the square root of the wall area at a theoretical airway with an internal perimeter of 10mm (Pi10). The scan with the highest lung volume was labelled as the reference scan and the scan with the lowest lung volume was labelled as the comparison scan. Pi10 derived from the comparison scan was corrected by multiplying it with the ratio of CT lung volume of the comparison scan to CT lung volume on the reference scan. Agreement of uncorrected and corrected Pi10 was studied with the Bland-Altman method, reliability with intra-class correlation coefficients (ICC), and power to detect changes over time was calculated.315 male participants were included. Limit of agreement and reliability for Pi10 was -0.61 to 0.57mm (ICC=0.87), which improved to -0.38 to 0.37mm (ICC=0.94) after correction for inspiration level. To detect a 15% change over 3 months, 71 subjects are needed for Pi10 and 26 subjects for Pi10 adjusted for inspiration level.Correcting Pi10 for differences in inspiration level improves reliability, agreement, and power to detect changes over time.
Document Type: Article
File Description: application/pdf
Language: English
ISSN: 0720-048X
DOI: 10.1016/j.ejrad.2016.09.009
Access URL: https://pubmed.ncbi.nlm.nih.gov/27776653
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/173155
https://doi.org/10.1016/j.ejrad.2016.09.009
https://hdl.handle.net/11370/4f017a5a-88e9-46c8-87b8-2dbe9a9b6594
https://doi.org/10.1016/j.ejrad.2016.09.009
https://research.rug.nl/en/publications/4f017a5a-88e9-46c8-87b8-2dbe9a9b6594
https://pubmed.ncbi.nlm.nih.gov/27776653/
http://dspace.library.uu.nl/handle/1874/342944
https://repository.ubn.ru.nl/handle/2066/173155
https://europepmc.org/abstract/MED/27776653
https://www.rug.nl/research/portal/en/publications/followup-of-ctderived-airway-wall-thickness(4f017a5a-88e9-46c8-87b8-2dbe9a9b6594).html
https://core.ac.uk/display/77073407
https://dspace.library.uu.nl/handle/1874/342944
https://pure.amsterdamumc.nl/en/publications/8f46df6a-2c3a-4441-a297-913338735866
https://doi.org/10.1016/j.ejrad.2016.09.009
https://repository.ubn.ru.nl//bitstream/handle/2066/173155/173155.pdf
https://hdl.handle.net/2066/173155
Rights: Elsevier TDM
Accession Number: edsair.doi.dedup.....b3af3a8f181aa8a11dcba41d63858518
Database: OpenAIRE
Description
Abstract:Airway wall thickness (AWT) is affected by changes in lung volume. This study evaluated whether correcting AWT on computed tomography (CT) for differences in inspiration level improves measurement agreement, reliability, and power to detect changes over time.Participants of the Dutch-Belgian lung cancer screening trial who underwent 3-month repeat CT for an indeterminate pulmonary nodule were included. AWT on CT was calculated by the square root of the wall area at a theoretical airway with an internal perimeter of 10mm (Pi10). The scan with the highest lung volume was labelled as the reference scan and the scan with the lowest lung volume was labelled as the comparison scan. Pi10 derived from the comparison scan was corrected by multiplying it with the ratio of CT lung volume of the comparison scan to CT lung volume on the reference scan. Agreement of uncorrected and corrected Pi10 was studied with the Bland-Altman method, reliability with intra-class correlation coefficients (ICC), and power to detect changes over time was calculated.315 male participants were included. Limit of agreement and reliability for Pi10 was -0.61 to 0.57mm (ICC=0.87), which improved to -0.38 to 0.37mm (ICC=0.94) after correction for inspiration level. To detect a 15% change over 3 months, 71 subjects are needed for Pi10 and 26 subjects for Pi10 adjusted for inspiration level.Correcting Pi10 for differences in inspiration level improves reliability, agreement, and power to detect changes over time.
ISSN:0720048X
DOI:10.1016/j.ejrad.2016.09.009