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High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients

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Název: High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients
Autoři: Scheiflinger, Alexandra, Schnoell, Julia, Heiduschka, Gregor, Kenner, Lukas, Kadletz-Wanke, Lorenz, Brkic, Faris, Al-Gboore, Sega, Jank, Bernhard J.
Zdroj: J Cancer Res Clin Oncol
Informace o vydavateli: Springer Science and Business Media LLC, 2023.
Rok vydání: 2023
Témata: Head and Neck Neoplasms, Squamous Cell Carcinoma of Head and Neck, Research, Papillomavirus Infections, Carcinoma, Squamous Cell, Humans, RNA, Messenger, Ubiquitin-Specific Proteases, Squamous Cell Carcinoma of Head and Neck Genetics Complications, Carcinoma, Squamous Cell Pathology, Head and Neck Neoplasms Genetics Complications, RNA, Messenger Genetics Metabolism, Ubiquitin-Specific Proteases Genetics, Papillomavirus Infections Complications Genetics, Prognosis, 3. Good health
Popis: Introduction Head and neck squamous cell carcinoma (HNSCC) is among the most common cancers in the world with a low survival rate and common diagnosis at late stages. Deubiquitination of proteins is involved in tumor growth, metastasis, apoptosis, and immunosuppressive pathways. The impact of the ubiquitin-specific protease (USP4) on survival was only scarcely investigated so far. The goal of our research was to analyze the association of USP4 expression with prognosis and clinicopathological features in HNSCC. Methods USP4 mRNA levels were derived from The Cancer Genome Atlas (TCGA) for a cohort of 510 patients. Protein expression of USP4 was analyzed by immunohistochemistry in a second cohort of 113 patients. Associations between USP4 levels and overall survival, disease-free survival and clinicopathological data were analyzed. Results High levels of USP4 mRNA were associated with prolonged overall survival in univariable analysis. There was no more association with survival after correction for the confounders HPV, stage and smoker status. High USP4 mRNA levels were linked to a lower T-stage, the patient’s age at diagnosis, and a positive HPV status. USP4 protein levels were not associated with prognosis or other features. Conclusion Since high USP4 mRNA was not an independent prognostic marker, we assume that the association is a result of the correlation of high USP4 mRNA with an HPV-positive status. Therefore, further investigation of USP4 mRNA and its association with the HPV status of HNSCC patients is warranted.
Druh dokumentu: Article
Other literature type
Popis souboru: application/pdf
Jazyk: English
ISSN: 1432-1335
0171-5216
DOI: 10.1007/s00432-023-04872-2
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37308746
https://phaidra.vetmeduni.ac.at/o:3414
https://doi.org/10.1007/s00432-023-04872-2
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....b2ccb7518d038de65ffa27c1aa2b449c
Databáze: OpenAIRE
Popis
Abstrakt:Introduction Head and neck squamous cell carcinoma (HNSCC) is among the most common cancers in the world with a low survival rate and common diagnosis at late stages. Deubiquitination of proteins is involved in tumor growth, metastasis, apoptosis, and immunosuppressive pathways. The impact of the ubiquitin-specific protease (USP4) on survival was only scarcely investigated so far. The goal of our research was to analyze the association of USP4 expression with prognosis and clinicopathological features in HNSCC. Methods USP4 mRNA levels were derived from The Cancer Genome Atlas (TCGA) for a cohort of 510 patients. Protein expression of USP4 was analyzed by immunohistochemistry in a second cohort of 113 patients. Associations between USP4 levels and overall survival, disease-free survival and clinicopathological data were analyzed. Results High levels of USP4 mRNA were associated with prolonged overall survival in univariable analysis. There was no more association with survival after correction for the confounders HPV, stage and smoker status. High USP4 mRNA levels were linked to a lower T-stage, the patient’s age at diagnosis, and a positive HPV status. USP4 protein levels were not associated with prognosis or other features. Conclusion Since high USP4 mRNA was not an independent prognostic marker, we assume that the association is a result of the correlation of high USP4 mRNA with an HPV-positive status. Therefore, further investigation of USP4 mRNA and its association with the HPV status of HNSCC patients is warranted.
ISSN:14321335
01715216
DOI:10.1007/s00432-023-04872-2