Characterizing the loss and acquisition of Tn2-like transposon in Klebsiella pneumoniae: Implications for carbapenemase gene dissemination
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| Názov: | Characterizing the loss and acquisition of Tn2-like transposon in Klebsiella pneumoniae: Implications for carbapenemase gene dissemination |
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| Autori: | Hong Lu, Li Cheng, Shu Cui, Xin Yi, Xueqin Li, Xiang Liu, Xiaomei Kong, Xiao Yu |
| Zdroj: | Journal of Global Antimicrobial Resistance, Vol 38, Iss, Pp 98-102 (2024) |
| Informácie o vydavateľovi: | Elsevier BV, 2024. |
| Rok vydania: | 2024 |
| Predmety: | Male, 0301 basic medicine, 0303 health sciences, Microbial Sensitivity Tests, Plasmid, Microbiology, KPC-2, QR1-502, beta-Lactamases, Klebsiella Infections, Anti-Bacterial Agents, 3. Good health, Klebsiella pneumoniae, 03 medical and health sciences, Bacterial Proteins, Carbapenems, DNA Transposable Elements, Humans, Transposon, Plasmids |
| Popis: | Over 1 year, two KPC-producing and two non-KPC-producing Klebsiella pneumoniae strains were isolated from a patient. Genome and DNA hybridization analyses revealed the first three strains as a clonal lineage, with carbapenem resistance changes due to a Tn2-like transposon on an IncR/IncFII plasmid. The fourth strain, carrying three plasmids, caused a lethal infection and represented a different lineage. All strains belonged to the ST11-SL47-OL101 type. This study highlights the Tn2-like transposon's role in carbapenemase gene spread and the importance of distinguishing between bacterial colonization and infection. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 2213-7165 |
| DOI: | 10.1016/j.jgar.2024.04.011 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/38719187 https://doaj.org/article/372aad52b1e54a519af56dc934463201 |
| Rights: | CC BY NC ND |
| Prístupové číslo: | edsair.doi.dedup.....b2b43950a5c6b08726899c6edf34dea3 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Over 1 year, two KPC-producing and two non-KPC-producing Klebsiella pneumoniae strains were isolated from a patient. Genome and DNA hybridization analyses revealed the first three strains as a clonal lineage, with carbapenem resistance changes due to a Tn2-like transposon on an IncR/IncFII plasmid. The fourth strain, carrying three plasmids, caused a lethal infection and represented a different lineage. All strains belonged to the ST11-SL47-OL101 type. This study highlights the Tn2-like transposon's role in carbapenemase gene spread and the importance of distinguishing between bacterial colonization and infection. |
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| ISSN: | 22137165 |
| DOI: | 10.1016/j.jgar.2024.04.011 |