Insulin resistance relates to DKA severity and affects insulin requirement in children with type 1 diabetes at onset
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| Názov: | Insulin resistance relates to DKA severity and affects insulin requirement in children with type 1 diabetes at onset |
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| Autori: | Mastromauro, Concetta, Polidori, Nella, Blasetti, Annalisa, Comegna, Laura, Chiarelli, Francesco, Mohn, Angelika, Giannini, Cosimo |
| Zdroj: | Pediatr Diabetes |
| Informácie o vydavateľovi: | Wiley, 2022. |
| Rok vydania: | 2022 |
| Predmety: | 03 medical and health sciences, Diabetes Mellitus, Type 1, Glucose, 0302 clinical medicine, Type 1 Diabetes: Pathophysiology and Prevention, Humans, Insulin, DKA, children, insulin administration, insulin resistance, type 1 diabetes, Insulin Resistance, Child, Retrospective Studies, Diabetic Ketoacidosis, 3. Good health |
| Popis: | Fluid and insulin treatments are the cornerstones of DKA management and indications on dosages are available. However, according to possible confounding factors, relevant data are still required to explain the different insulin dosages adopted at diabetes onset, particularly based upon insulin sensitivity.We aimed to explore whether DKA severity is related to different insulin sensitivity states, thus resulting in different insulin requirement at diabetes onset.Retrospective data from hospital records of 62 newly diagnosed children with type 1 diabetes with DKA were analyzed. The population was divided into three groups: severe, moderate, and mild DKA. Anthropometric, laboratory test, insulin, and glucose administration data were analyzed. The Glucose Infusion Rate (GIR), Insulin Infusion Rate (IIR), and GIR/IIR were calculated and used as indexes of insulin sensitivity. The area under the curve (AUC) for insulin and glucose infusion was calculated.Moving among the three groups, IIR decreased while GIR and GIR/IIR increased from severe to mild DKA group (all p |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1399-5448 1399-543X |
| DOI: | 10.1111/pedi.13424 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/36183171 https://onlinelibrary.wiley.com/doi/10.1111/pedi.13424 https://doi.org/10.1111/pedi.13424 https://hdl.handle.net/11564/790951 |
| Rights: | CC BY NC |
| Prístupové číslo: | edsair.doi.dedup.....b21ad6422a53f5949d488b0610a8e202 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Fluid and insulin treatments are the cornerstones of DKA management and indications on dosages are available. However, according to possible confounding factors, relevant data are still required to explain the different insulin dosages adopted at diabetes onset, particularly based upon insulin sensitivity.We aimed to explore whether DKA severity is related to different insulin sensitivity states, thus resulting in different insulin requirement at diabetes onset.Retrospective data from hospital records of 62 newly diagnosed children with type 1 diabetes with DKA were analyzed. The population was divided into three groups: severe, moderate, and mild DKA. Anthropometric, laboratory test, insulin, and glucose administration data were analyzed. The Glucose Infusion Rate (GIR), Insulin Infusion Rate (IIR), and GIR/IIR were calculated and used as indexes of insulin sensitivity. The area under the curve (AUC) for insulin and glucose infusion was calculated.Moving among the three groups, IIR decreased while GIR and GIR/IIR increased from severe to mild DKA group (all p |
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| ISSN: | 13995448 1399543X |
| DOI: | 10.1111/pedi.13424 |