A fast pathway for fear in human amygdala
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| Název: | A fast pathway for fear in human amygdala |
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| Autoři: | Patrik Vuilleumier, Constantino Méndez-Bértolo, Stephan Moratti, Bryan A. Strange, Fernando Lopez-Sosa, Yee H Mah, Roberto Martínez-Alvarez, Antonio Gil-Nagel, Rafael Toledano |
| Zdroj: | Nature Neuroscience, Vol. 19, No 8 (2016) pp. 1041-1049 |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2016. |
| Rok vydání: | 2016 |
| Témata: | Adult, Male, 0301 basic medicine, 616.8, Happiness, 128.37, Magnetic Resonance Imaging/methods, Fear/physiology, 03 medical and health sciences, 0302 clinical medicine, Task Performance and Analysis, Reaction Time, Humans, Visual Cortex, Brain Mapping, Face/physiology, Visual Cortex/physiology, Fear, Amygdala, Magnetic Resonance Imaging, ddc:616.8, ddc:128.37, Facial Expression, Reaction Time/physiology, Face, Amygdala/physiology, Female |
| Popis: | A fast, subcortical pathway to the amygdala is thought to have evolved to enable rapid detection of threat. This pathway's existence is fundamental for understanding nonconscious emotional responses, but has been challenged as a result of a lack of evidence for short-latency fear-related responses in primate amygdala, including humans. We recorded human intracranial electrophysiological data and found fast amygdala responses, beginning 74-ms post-stimulus onset, to fearful, but not neutral or happy, facial expressions. These responses had considerably shorter latency than fear responses that we observed in visual cortex. Notably, fast amygdala responses were limited to low spatial frequency components of fearful faces, as predicted by magnocellular inputs to amygdala. Furthermore, fast amygdala responses were not evoked by photographs of arousing scenes, which is indicative of selective early reactivity to socially relevant visual information conveyed by fearful faces. These data therefore support the existence of a phylogenetically old subcortical pathway providing fast, but coarse, threat-related signals to human amygdala. |
| Druh dokumentu: | Article |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/nn.4324 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/27294508 https://www.nature.com/articles/nn.4324.pdf https://www.ncbi.nlm.nih.gov/pubmed/27294508 https://nature.com/articles/nn.4324 https://archive-ouverte.unige.ch/unige:127276 http://www.ncbi.nlm.nih.gov/pubmed/27294508 https://www.nature.com/articles/doi:10.1038/nn.4324 https://archive-ouverte.unige.ch/unige:127276 https://doi.org/10.1038/nn.4324 https://archive-ouverte.unige.ch/unige:127276 |
| Rights: | Springer TDM |
| Přístupové číslo: | edsair.doi.dedup.....b0fa765a6c2d482fa742f37b621a994b |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | A fast, subcortical pathway to the amygdala is thought to have evolved to enable rapid detection of threat. This pathway's existence is fundamental for understanding nonconscious emotional responses, but has been challenged as a result of a lack of evidence for short-latency fear-related responses in primate amygdala, including humans. We recorded human intracranial electrophysiological data and found fast amygdala responses, beginning 74-ms post-stimulus onset, to fearful, but not neutral or happy, facial expressions. These responses had considerably shorter latency than fear responses that we observed in visual cortex. Notably, fast amygdala responses were limited to low spatial frequency components of fearful faces, as predicted by magnocellular inputs to amygdala. Furthermore, fast amygdala responses were not evoked by photographs of arousing scenes, which is indicative of selective early reactivity to socially relevant visual information conveyed by fearful faces. These data therefore support the existence of a phylogenetically old subcortical pathway providing fast, but coarse, threat-related signals to human amygdala. |
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| ISSN: | 15461726 10976256 |
| DOI: | 10.1038/nn.4324 |