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Single nucleotide polymorphisms of complement component 5 and periodontitis

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Název: Single nucleotide polymorphisms of complement component 5 and periodontitis
Autoři: Leung, WK, Song, YQ, Zee, KY, Chai, L
Zdroj: Journal of Periodontal Research. 45:301-308
Informace o vydavateli: Wiley, 2010.
Rok vydání: 2010
Témata: Chronic Periodontitis - genetics - immunology, Male, Adult, Guanine, Adolescent, Genotype, Aggressive Periodontitis - genetics - immunology, Polymorphism, genetic, Linkage Disequilibrium, Complement C5 - genetics, Young Adult, Cytosine, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Genetic, Gene Frequency - genetics, Gene Frequency, Risk Factors, Single Nucleotide - genetics, Humans, Immunologic Factors, Periodontitis - genetics - immunology, Polymorphism, Periodontitis, Introns - genetics, Genetic Variation - genetics, Adenine, Smoking, Age Factors, Complement C5, Genetic Variation, Middle Aged, Polymorphism, Single Nucleotide - genetics, Introns, 3. Good health, Linkage Disequilibrium - genetics, Aggressive Periodontitis, Haplotypes, Case-Control Studies, Immunologic Factors - genetics, Chronic Periodontitis, Hong Kong, Female
Popis: Polymorphisms of host defence genes might increase one's risks for periodontitis. This study investigated whether tagging single nucleotide polymorphisms (SNPs) of the gene encoding complement component 5 (C5) are associated with periodontitis in a Hong Kong Chinese population.Eleven tagging SNPs of 229 patients with at least moderate periodontitis and 207 control subjects without periodontitis were genotyped using an i-plexGOLD MassARRAY mass-spectrometry system.Genotype AG of SNP rs17611 was more prevalent in the group of periodontitis patients than in the controls (54.6% vs. 41.7%, p = 0.007). The haplotype CGCA of the haplotype block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis in a dominant model (p = 0.001). The SNP rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was also significantly associated with periodontitis (p = 0.006).The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population.
Druh dokumentu: Article
Conference object
Jazyk: English
ISSN: 1600-0765
0022-3484
DOI: 10.1111/j.1600-0765.2009.01234.x
DOI: 10.1111/j.1600-051x.2009.01404.x
Přístupová URL adresa: http://hub.hku.hk/bitstream/10722/129097/1/Content.pdf
https://pubmed.ncbi.nlm.nih.gov/19909405
https://core.ac.uk/display/37953466
https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0765.2009.01234.x
https://hub.hku.hk/bitstream/10722/129097/1/Content.pdf
https://www.ncbi.nlm.nih.gov/pubmed/19909405
https://www.cabdirect.org/abstracts/20103150326.html
https://pubmed.ncbi.nlm.nih.gov/19909405/
http://hdl.handle.net/10722/129097
http://hdl.handle.net/10722/61359
Rights: Wiley TDM
CC BY NC ND
Přístupové číslo: edsair.doi.dedup.....b04a1b94fa14313a5f8b3f2d7284989b
Databáze: OpenAIRE
Popis
Abstrakt:Polymorphisms of host defence genes might increase one's risks for periodontitis. This study investigated whether tagging single nucleotide polymorphisms (SNPs) of the gene encoding complement component 5 (C5) are associated with periodontitis in a Hong Kong Chinese population.Eleven tagging SNPs of 229 patients with at least moderate periodontitis and 207 control subjects without periodontitis were genotyped using an i-plexGOLD MassARRAY mass-spectrometry system.Genotype AG of SNP rs17611 was more prevalent in the group of periodontitis patients than in the controls (54.6% vs. 41.7%, p = 0.007). The haplotype CGCA of the haplotype block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis in a dominant model (p = 0.001). The SNP rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was also significantly associated with periodontitis (p = 0.006).The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population.
ISSN:16000765
00223484
DOI:10.1111/j.1600-0765.2009.01234.x