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Renal Resistive Index and 10-Year Risk of Cardiovascular Disease Predicted by Framingham Risk Score and Pooled Cohort Equations: An Observational Study in Hypertensive Individuals Without Cardiovascular Disease

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Title: Renal Resistive Index and 10-Year Risk of Cardiovascular Disease Predicted by Framingham Risk Score and Pooled Cohort Equations: An Observational Study in Hypertensive Individuals Without Cardiovascular Disease
Authors: Giulio Geraci, Alessandra Sorce, Luca Zanoli, Vincenzo Calabrese, Giuseppe Cuttone, Alessandro Mattina, Pietro Ferrara, Ligia J. Dominguez, Riccardo Polosa, Giuseppe Mulè, Caterina Carollo
Source: High Blood Pressure & Cardiovascular Prevention. 32:311-322
Publisher Information: Springer Science and Business Media LLC, 2025.
Publication Year: 2025
Subject Terms: Male, Adult, Ultrasonography, Doppler, Duplex, Time Factors, Blood Pressure, Middle Aged, Cardiovascular risk, Kidney, Prognosis, Risk Assessment, Renal Circulation, Decision Support Techniques, Renal Resistive Index, Predictive Value of Tests, Cardiovascular Diseases, Heart Disease Risk Factors, Risk Factors, Hypertension, Humans, Female, Vascular Resistance, Renal function, Aged
Description: The renal resistive index (RRI) has been widely shown to be related with subclinical vascular damage in individuals with essential hypertension, as well as in other populations. However, limited data exist regarding the association between RRI and cardiovascular (CV) events in hypertensive individuals. Additionally, it is unclear whether the 10-year risk of CV disease, as predicted by validated score equations, is associated with impaired intrarenal hemodynamics.The aim of our study was to analyze the relationship between RRI and both the FS and ASCVD in hypertensive individuals with no history of CV events.A total of 742 individuals with essential hypertension (40-75 years) were enrolled. RRI was assessed in all patients using Duplex-Doppler ultrasonography, and the 10-year risk of cardiovascular disease was calculated using both the Framingham risk score (FS) and atherosclerotic cardiovascular disease risk score (ASCVD) through validated equations.Higher RRI values were observed in patients with calculated CV risk ≥ 20% compared to those with lower risk (all p 0.67 and >0.65 were associated with a high CV risk (≥ 20%), as calculated through FS and ASCVD equations, respectively.RRI can be considered a marker of overall CV risk in hypertensive patients, independent of renal function.
Document Type: Article
Language: English
ISSN: 1179-1985
DOI: 10.1007/s40292-025-00714-z
Access URL: https://pubmed.ncbi.nlm.nih.gov/40244525
https://hdl.handle.net/10281/551001
https://doi.org/10.1007/s40292-025-00714-z
https://hdl.handle.net/20.500.11769/671234
https://doi.org/10.1007/s40292-025-00714-z
Rights: Springer Nature TDM
Accession Number: edsair.doi.dedup.....af28bbc1a7723006fd04313f8f55ee65
Database: OpenAIRE
Description
Abstract:The renal resistive index (RRI) has been widely shown to be related with subclinical vascular damage in individuals with essential hypertension, as well as in other populations. However, limited data exist regarding the association between RRI and cardiovascular (CV) events in hypertensive individuals. Additionally, it is unclear whether the 10-year risk of CV disease, as predicted by validated score equations, is associated with impaired intrarenal hemodynamics.The aim of our study was to analyze the relationship between RRI and both the FS and ASCVD in hypertensive individuals with no history of CV events.A total of 742 individuals with essential hypertension (40-75 years) were enrolled. RRI was assessed in all patients using Duplex-Doppler ultrasonography, and the 10-year risk of cardiovascular disease was calculated using both the Framingham risk score (FS) and atherosclerotic cardiovascular disease risk score (ASCVD) through validated equations.Higher RRI values were observed in patients with calculated CV risk ≥ 20% compared to those with lower risk (all p 0.67 and >0.65 were associated with a high CV risk (≥ 20%), as calculated through FS and ASCVD equations, respectively.RRI can be considered a marker of overall CV risk in hypertensive patients, independent of renal function.
ISSN:11791985
DOI:10.1007/s40292-025-00714-z