Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism
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| Název: | Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism |
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| Autoři: | Daan Bunt, Markus Schwalbe, Fittree Hayeeawaema, Sahar El Aidy |
| Zdroj: | Gut Microbes Gut Microbes, Vol 17, Iss 1 (2025) |
| Informace o vydavateli: | Informa UK Limited, 2025. |
| Rok vydání: | 2025 |
| Témata: | Adult, Male, Feces/microbiology, Xanthones, norathyriol, RC799-869, Feces, Young Adult, Humans, Gastrointestinal Microbiome/drug effects, metabolites, gut microbiota, Bacteria, Fatty Acids, Diseases of the digestive system. Gastroenterology, Fatty Acids, Volatile, Xanthones/metabolism, Volatile/metabolism, Gastrointestinal Microbiome, Uric Acid, Bacteria/metabolism, Mangiferin, urate, C-glycosides, Female, Uric Acid/metabolism, Research Paper |
| Popis: | Mangiferin (MAN), a natural C-glycosylxanthone, is recognized for its health-promoting effects in traditional medicinal preparations. However, its poor bioavailability and limited intestinal permeability restrict its direct biological activity in vivo. Previous studies have suggested a potential bacterial breakdown of MAN into norathyriol (NOR), an aglycone with significantly higher bioavailability and absorption. Yet, the prevalence of MAN-metabolizing microbes, the presence of MAN or NOR within the gut microbial community, and their effects on the composition and metabolic activity of the gut microbiome remain unclear. In this study, fecal samples from healthy adult volunteers treated with MAN revealed its conversion to NOR, with interindividual variation attributed to the uncultured bacterial strain CAKRHR01 sp934339005. While MAN had minimal impact on microbial composition and metabolic activity, NOR treatment significantly increased pH, reduced overall bacterial cell counts, and selectively suppressed short-chain fatty acid-producing bacteria, including Faecalibacterium prausnitzii as well as urate consumers, such as Enterocloster bolteae. These findings underscore the potential of NOR to modulate gut microbial activity and highlight the importance of understanding microbiome-mediated metabolism when assessing the health implications of phytochemicals. |
| Druh dokumentu: | Article Other literature type |
| Jazyk: | English |
| ISSN: | 1949-0984 1949-0976 |
| DOI: | 10.1080/19490976.2025.2508422 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/40401774 https://doaj.org/article/dd9071f49a9245919389d4c84d71d42a https://research.rug.nl/en/publications/1c5cb5ea-cf43-42cb-bc31-2fec1d20ad97 https://doi.org/10.1080/19490976.2025.2508422 https://hdl.handle.net/11370/1c5cb5ea-cf43-42cb-bc31-2fec1d20ad97 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
| Přístupové číslo: | edsair.doi.dedup.....aed4b3ce4e72f74023f5808ac80c5e4c |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Mangiferin (MAN), a natural C-glycosylxanthone, is recognized for its health-promoting effects in traditional medicinal preparations. However, its poor bioavailability and limited intestinal permeability restrict its direct biological activity in vivo. Previous studies have suggested a potential bacterial breakdown of MAN into norathyriol (NOR), an aglycone with significantly higher bioavailability and absorption. Yet, the prevalence of MAN-metabolizing microbes, the presence of MAN or NOR within the gut microbial community, and their effects on the composition and metabolic activity of the gut microbiome remain unclear. In this study, fecal samples from healthy adult volunteers treated with MAN revealed its conversion to NOR, with interindividual variation attributed to the uncultured bacterial strain CAKRHR01 sp934339005. While MAN had minimal impact on microbial composition and metabolic activity, NOR treatment significantly increased pH, reduced overall bacterial cell counts, and selectively suppressed short-chain fatty acid-producing bacteria, including Faecalibacterium prausnitzii as well as urate consumers, such as Enterocloster bolteae. These findings underscore the potential of NOR to modulate gut microbial activity and highlight the importance of understanding microbiome-mediated metabolism when assessing the health implications of phytochemicals. |
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| ISSN: | 19490984 19490976 |
| DOI: | 10.1080/19490976.2025.2508422 |