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Proteinuria and the risk of Incident atrial fibrillation according to glycemic stages: a nationwide population-based cohort study

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Title: Proteinuria and the risk of Incident atrial fibrillation according to glycemic stages: a nationwide population-based cohort study
Authors: Yeo, Muhan, Lee, So-Ryoung, Choi, Eue-Keun, Choi, JungMin, Lee, Kyung-Yeon, Kwon, Soonil, Ahn, Hyo-Jeong, Kim, Bong-Seong, Han, Kyung-Do, Oh, Seil, Lip, Gregory Y. H.
Source: Cardiovasc Diabetol
Cardiovascular Diabetology, Vol 24, Iss 1, Pp 1-11 (2025)
Yeo, M, Lee, S-R, Choi, E-K, Choi, J, Lee, K-Y, Kwon, S, Ahn, H-J, Kim, B-S, Han, K-D, Oh, S & Lip, G Y H 2025, 'Proteinuria and the risk of Incident atrial fibrillation according to glycemic stages: a nationwide population-based cohort study', Cardiovascular Diabetology, vol. 24, no. 1, 41. https://doi.org/10.1186/s12933-025-02590-2
Publisher Information: Springer Science and Business Media LLC, 2025.
Publication Year: 2025
Subject Terms: Male, Blood Glucose, Adult, Time Factors, Databases, Factual, Urinalysis, Risk Assessment, Prediabetic State, Risk Factors, Atrial Fibrillation, Republic of Korea, Diabetes Mellitus, Diseases of the circulatory (Cardiovascular) system, Humans, Aged, Prediabetic State/epidemiology, Blood Glucose/metabolism, Research, Incidence, Middle Aged, Prognosis, Atrial fibrillation, Proteinuria, RC666-701, Atrial Fibrillation/epidemiology, Diabetes Mellitus/epidemiology, Female, Proteinuria/epidemiology, Republic of Korea/epidemiology, Biomarkers/blood, Biomarkers
Description: Background Diabetes mellitus (DM) and proteinuria each independently raise the risk of atrial fibrillation (AF). We aimed to investigate the relationship between proteinuria and the risk of incident AF across glycemic stages. Methods A cohort of 4,044,524 individuals without prior AF and type 1 DM was selected from the 2009 Korean National Health Insurance Service health checkup data. The individuals were categorized into five glycemic stages: normal, prediabetes, new-onset DM, early DM ( Results Overall, the cohort (mean age 47 ± 14 years, 44.8% female) showed increasing annual AF incidence rates from 2.05 to 7.22 per 1000 person-years from normal to late DM (p p Conclusions Proteinuria is an independent and significant risk factor for incident AF at all glycemic stages. The risk of incident AF in patients with DM can be stratified by measuring the level of proteinuria rather than comparing the duration of DM. Tailoring clinical strategies to proteinuria level could potentially mitigate this risk, improving patient outcomes. Graphical abstract
Document Type: Article
Other literature type
File Description: application/pdf
Language: English
ISSN: 1475-2840
DOI: 10.1186/s12933-025-02590-2
Access URL: https://pubmed.ncbi.nlm.nih.gov/39856720
https://doaj.org/article/a15d61475f594762b2016f4cc4a23661
https://vbn.aau.dk/ws/files/767955863/Yeo_et_al._2025_._Proteinuria_and_the_risk_of_Incident_atrial_fibrillation_according_to_glycemic_stages_-_a_nationwide_population-based_cohort_study.pdf
https://vbn.aau.dk/da/publications/b9ea211f-07c5-4e49-b740-44ee6cb88b26
https://doi.org/10.1186/s12933-025-02590-2
http://www.scopus.com/inward/record.url?scp=85217000323&partnerID=8YFLogxK
Rights: CC BY
Accession Number: edsair.doi.dedup.....abfebdd4d5f2cb3ecaa3fe3101b3e3cf
Database: OpenAIRE
Description
Abstract:Background Diabetes mellitus (DM) and proteinuria each independently raise the risk of atrial fibrillation (AF). We aimed to investigate the relationship between proteinuria and the risk of incident AF across glycemic stages. Methods A cohort of 4,044,524 individuals without prior AF and type 1 DM was selected from the 2009 Korean National Health Insurance Service health checkup data. The individuals were categorized into five glycemic stages: normal, prediabetes, new-onset DM, early DM ( Results Overall, the cohort (mean age 47 ± 14 years, 44.8% female) showed increasing annual AF incidence rates from 2.05 to 7.22 per 1000 person-years from normal to late DM (p p Conclusions Proteinuria is an independent and significant risk factor for incident AF at all glycemic stages. The risk of incident AF in patients with DM can be stratified by measuring the level of proteinuria rather than comparing the duration of DM. Tailoring clinical strategies to proteinuria level could potentially mitigate this risk, improving patient outcomes. Graphical abstract
ISSN:14752840
DOI:10.1186/s12933-025-02590-2