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The effects of low dose aluminum on hemorheological and hematological parameters in rats

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Title: The effects of low dose aluminum on hemorheological and hematological parameters in rats
Authors: Turgut, Sebahat, Bor-Küçükatay, Melek, Emmungil, Gülten, Atsak, Piray, Turgut, Günfer
Source: Archives of Toxicology. 81:11-17
Publisher Information: Springer Science and Business Media LLC, 2006.
Publication Year: 2006
Subject Terms: erythrocyte deformability, Erythrocyte Aggregation, Erythrocyte Indices, Male, 0301 basic medicine, Erythrocytes, erythrocyte membrane, Wistar, environmental exposure, animal cell, Erythrocyte aggregation, rat, aluminum sulfate, blood rheology, 0303 health sciences, mean corpuscular volume, article, Hematology, Red blood cell deformability, Blood Viscosity, 3. Good health, priority journal, Hematocrit, sodium chloride, Hemoglobinometry, Alum Compounds, blood sampling, Drug, Injections, Intraperitoneal, hematocrit, animal experiment, hematological parameters, Alum Compounds/administration & dosage/*toxicity, Animals, Blood Viscosity/*drug effects, Dose-Response Relationship, Drug, Erythrocyte Aggregation/*drug effects, Erythrocyte Deformability/*drug effects, Erythrocyte Indices/drug effects, Erythrocytes/drug effects/metabolism, Hematology/methods, Hemoglobinometry/methods, Hemorheology/methods, Rats, Rats, Wistar, blood clotting, analyzer, shear stress, Injections, Dose-Response Relationship, body weight, 03 medical and health sciences, male, Erythrocyte Deformability, Animalia, Intraperitoneal, controlled study, Plasma viscosity, nonhuman, Rattus, animal model, aluminum, viscometer, Hemorheology, blood viscosity, plasma viscosity, Blood viscosity, erythrocyte aggregation, Aluminum
Description: Aluminum (Al) is a nonessential element and humans are constantly exposed to Al as a result of an increase in industrialization and improving technology practices. Al toxicity can induce several clinical disorders such as neurotoxicity, gastrointestinal toxicity, hepatotoxicity, bone diseases, and anemia. This study aimed at evaluating the possible effects of short term and low dose Al exposure on hemorheological and hematological parameters in rats. Fourteen young, male Wistar albino rats were divided into two groups: 1 mg/200 g body weight of aluminum sulfate (Al(2)(SO(4))(3) was injected intraperitoneally to the first group for two weeks, three times a week. The animals of the control group received only physiological saline solution during this period. At the end of the experimental period, anticoagulated blood samples were collected and hematological parameters were determined using an electronic hematology analyzer. Red blood cell (RBC) deformability and aggregation were measured using an ektacytometer (LORCA) and plasma and whole blood viscosities were determined with a Wells-Brookfield cone-plate rotational viscometer. Significant decreases in mean corpuscular volume (MCV), red blood cell (RBC) deformability at low shear stress levels, the aggregation half time (t1/2) and the amplitude (AMP) of aggregation and significant increments in whole blood viscosity (WBV) at native and 40% hematocrit (Hct) of Al-treated rats have been observed. In conclusion, low dose Al(2)(SO(4))(3) exposure for a short-time may be responsible for alterations in either rheological properties of blood or hemorheological properties through a remarkable effect on RBC membrane mechanical properties . These alterations may also play an important role in the development of anemia in the Al-treated animals.
Document Type: Article
Conference object
Language: English
ISSN: 1432-0738
0340-5761
DOI: 10.1007/s00204-006-0119-8
Access URL: https://pubmed.ncbi.nlm.nih.gov/16721596
https://link.springer.com/article/10.1007/s00204-006-0119-8
https://link.springer.com/article/10.1007/s00204-006-0119-8/fulltext.html
https://link.springer.com/content/pdf/10.1007%2Fs00204-006-0119-8.pdf
https://europepmc.org/article/MED/16721596
https://hdl.handle.net/11499/18647
https://hdl.handle.net/11499/4371
https://doi.org/10.1007/s00204-006-0119-8
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4371
Rights: Springer TDM
Accession Number: edsair.doi.dedup.....ab2765a0293dd73e34f4ff32e3b8225e
Database: OpenAIRE
Description
Abstract:Aluminum (Al) is a nonessential element and humans are constantly exposed to Al as a result of an increase in industrialization and improving technology practices. Al toxicity can induce several clinical disorders such as neurotoxicity, gastrointestinal toxicity, hepatotoxicity, bone diseases, and anemia. This study aimed at evaluating the possible effects of short term and low dose Al exposure on hemorheological and hematological parameters in rats. Fourteen young, male Wistar albino rats were divided into two groups: 1 mg/200 g body weight of aluminum sulfate (Al(2)(SO(4))(3) was injected intraperitoneally to the first group for two weeks, three times a week. The animals of the control group received only physiological saline solution during this period. At the end of the experimental period, anticoagulated blood samples were collected and hematological parameters were determined using an electronic hematology analyzer. Red blood cell (RBC) deformability and aggregation were measured using an ektacytometer (LORCA) and plasma and whole blood viscosities were determined with a Wells-Brookfield cone-plate rotational viscometer. Significant decreases in mean corpuscular volume (MCV), red blood cell (RBC) deformability at low shear stress levels, the aggregation half time (t1/2) and the amplitude (AMP) of aggregation and significant increments in whole blood viscosity (WBV) at native and 40% hematocrit (Hct) of Al-treated rats have been observed. In conclusion, low dose Al(2)(SO(4))(3) exposure for a short-time may be responsible for alterations in either rheological properties of blood or hemorheological properties through a remarkable effect on RBC membrane mechanical properties . These alterations may also play an important role in the development of anemia in the Al-treated animals.
ISSN:14320738
03405761
DOI:10.1007/s00204-006-0119-8