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Sarcopenia, Low Handgrip Strength, and Low Absolute Muscle Mass Predict Long-Term Mortality in Older Hospitalized Patients: An Observational Inception Cohort Study: An Observational Inception Cohort Study

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Název: Sarcopenia, Low Handgrip Strength, and Low Absolute Muscle Mass Predict Long-Term Mortality in Older Hospitalized Patients: An Observational Inception Cohort Study: An Observational Inception Cohort Study
Autoři: Kira Scheerman, Carel G.M. Meskers, Sjors Verlaan, Andrea B. Maier
Zdroj: Scheerman, K, Meskers, C G M, Verlaan, S & Maier, A B 2021, 'Sarcopenia, Low Handgrip Strength, and Low Absolute Muscle Mass Predict Long-Term Mortality in Older Hospitalized Patients: An Observational Inception Cohort Study', Journal of the American Medical Directors Association, vol. 22, no. 4, pp. 816-820.e2. https://doi.org/10.1016/j.jamda.2020.12.016
Informace o vydavateli: Elsevier BV, 2021.
Rok vydání: 2021
Témata: Male, Sarcopenia, Hand Strength, mortality, 3. Good health, sarcopenia, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, muscle mass, muscle strength, Humans, Female, Muscle Strength, Prospective Studies, Muscle, Skeletal, hospitalization, Aged
Popis: Sarcopenia is highly prevalent in hospitalized older patients and associated with short-term mortality. This study aimed to investigate whether sarcopenia and its measures handgrip strength (HGS) and muscle mass at hospital admission were associated with long-term mortality in a cohort of hospitalized older patients.Observational, prospective, longitudinal inception cohort study.Academic teaching hospital; patients age ≥70 years admitted to the internal medicine, acute admission, trauma, or orthopedic wards.HGS and muscle mass were measured at admission using a hand dynamometer and bioelectrical impedance analysis. Sarcopenia was determined based on the European Working Group on Sarcopenia in Older People definition. HGS and muscle mass (skeletal muscle mass index, appendicular lean mass, relative skeletal muscle mass) were expressed as sex-specific tertiles. The associations of sarcopenia, HGS, and muscle mass with mortality (during a follow-up of 3.4-4.1 years) were analyzed using Cox regression, adjusted for age, sex, comorbidity, and weight or height. Associations of HGS and muscle mass were stratified by sex.Out of 363 patients [mean age: 79.6 years (standard deviation: 6.4), 49.9% female] 49% died. Probable sarcopenia (prevalence of 53.7%) and sarcopenia (prevalence of 20.8%) were significantly associated with long-term mortality [hazard ratio (HR) 1.53, 95% confidence interval (CI) 1.08‒2.17 and 1.71 95% CI 1.12‒2.61, respectively]. Low HGS, skeletal muscle mass index, and appendicular lean mass were associated with a higher mortality risk (lowest tertile vs highest tertile: HR 2.660, 95% CI 1.40‒5.05; HR 1.95, 95% CI 1.06‒3.58 and HR 1.99 (95% CI 1.12‒3.53) in male patients. No statistically significant associations of relative muscle mass with mortality were found.Sarcopenia and its measures (low HGS and low absolute muscle mass at admission) predict long-term mortality in older hospitalized patients.
Druh dokumentu: Article
Jazyk: English
ISSN: 1525-8610
DOI: 10.1016/j.jamda.2020.12.016
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/33453174
https://pubmed.ncbi.nlm.nih.gov/33453174/
https://www.ncbi.nlm.nih.gov/pubmed/33453174
https://findanexpert.unimelb.edu.au/scholarlywork/1492758-sarcopenia--low-handgrip-strength--and-low-absolute-muscle-mass-predict-long-term-mortality-in-older-hospitalized-patients--an-observational-inception-cohort-study
https://www.narcis.nl/publication/RecordID/oai%3Apure.atira.dk%3Apublications%2Fe3b34948-1516-4bb7-a3ba-b0040fc0fc42
https://khepri-node.dev.meta-infra.org/papers/sarcopenia-low-handgrip-strength-and-low-absolute/33453174
https://www.sciencedirect.com/science/article/abs/pii/S1525861020310653
https://research.vumc.nl/en/publications/e3b34948-1516-4bb7-a3ba-b0040fc0fc42
Rights: Elsevier TDM
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Přístupové číslo: edsair.doi.dedup.....aaa556b44fa7bcc2cb872aadb11c36e0
Databáze: OpenAIRE
Popis
Abstrakt:Sarcopenia is highly prevalent in hospitalized older patients and associated with short-term mortality. This study aimed to investigate whether sarcopenia and its measures handgrip strength (HGS) and muscle mass at hospital admission were associated with long-term mortality in a cohort of hospitalized older patients.Observational, prospective, longitudinal inception cohort study.Academic teaching hospital; patients age ≥70 years admitted to the internal medicine, acute admission, trauma, or orthopedic wards.HGS and muscle mass were measured at admission using a hand dynamometer and bioelectrical impedance analysis. Sarcopenia was determined based on the European Working Group on Sarcopenia in Older People definition. HGS and muscle mass (skeletal muscle mass index, appendicular lean mass, relative skeletal muscle mass) were expressed as sex-specific tertiles. The associations of sarcopenia, HGS, and muscle mass with mortality (during a follow-up of 3.4-4.1 years) were analyzed using Cox regression, adjusted for age, sex, comorbidity, and weight or height. Associations of HGS and muscle mass were stratified by sex.Out of 363 patients [mean age: 79.6 years (standard deviation: 6.4), 49.9% female] 49% died. Probable sarcopenia (prevalence of 53.7%) and sarcopenia (prevalence of 20.8%) were significantly associated with long-term mortality [hazard ratio (HR) 1.53, 95% confidence interval (CI) 1.08‒2.17 and 1.71 95% CI 1.12‒2.61, respectively]. Low HGS, skeletal muscle mass index, and appendicular lean mass were associated with a higher mortality risk (lowest tertile vs highest tertile: HR 2.660, 95% CI 1.40‒5.05; HR 1.95, 95% CI 1.06‒3.58 and HR 1.99 (95% CI 1.12‒3.53) in male patients. No statistically significant associations of relative muscle mass with mortality were found.Sarcopenia and its measures (low HGS and low absolute muscle mass at admission) predict long-term mortality in older hospitalized patients.
ISSN:15258610
DOI:10.1016/j.jamda.2020.12.016