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An In Vitro Study of the Ultrasonic Axial Transmission Technique at the Radius: 1-MHz Velocity Measurements Are Sensitive to Both Mineralization and Intracortical Porosity

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Title: An In Vitro Study of the Ultrasonic Axial Transmission Technique at the Radius: 1-MHz Velocity Measurements Are Sensitive to Both Mineralization and Intracortical Porosity
Authors: Bossy, Emmanuel, Talmant, Maryline, Peyrin, Françoise, Akrout, Lëila, Cloetens, Peter, Laugier, Pascal
Contributors: Laugier, Pascal, Laboratoire d'Imagerie Paramétrique (LIP), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR58-Centre National de la Recherche Scientifique (CNRS), European Synchrotron Radiation Facility (ESRF), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Source: Journal of Bone and Mineral Research. 19:1548-1556
Publisher Information: Oxford University Press (OUP), 2004.
Publication Year: 2004
Subject Terms: Male, 0301 basic medicine, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, MESH: Calcification, Sensitivity and Specificity, 01 natural sciences, MESH: Linear Models, 03 medical and health sciences, MESH: Porosity, Calcification, Physiologic, 0103 physical sciences, 80 and over, Humans, Physiologic, Aged, Ultrasonography, MESH: Aged, Aged, 80 and over, MESH: Middle Aged, MESH: Humans, Middle Aged, MESH: Male, MESH: Sensitivity and Specificity, Radius, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, MESH: Synchrotrons, Linear Models, Female, MESH: Radius, MESH: Female, Porosity, Synchrotrons
Description: The ultrasonic axial transmission technique allows for investigating skeletal sites such as the cortical layer of long bones (radius, tibia, phalanges). Using synchrotron radiation μCT, we investigated, in vitro, the relationships between 1-MHz axial transmission SOS measurements at the radius and site-matched measurements of C.Th, POR, MIN, and vBMD. Introduction: The ultrasonic axial transmission technique allows for investigating skeletal sites such as the cortical layer of long bones (radius, tibia, phalanges). Materials and Methods:Using synchrotron radiation μCT, we investigated, in vitro, the relationships between 1-MHz axial transmission speed of sound (SOS) measurements at the radius and site-matched measurements of cortical thickness (C.Th), intracortical porosity (POR), tissue mineralization (MIN), and volumetric BMD (vBMD). SOS measurements were based on bidirectional axial transmission and were performed with a 1-MHz proprietary probe on 39 excised human radii. Results: The highest correlations between SOS values and bone parameters (R2SOS/POR = 0.28, p < 10−3; R2SOS/MIN = 0.38, p < 10−4; R2SOS/vBMD = 0.57, p < 10−3) were found for bone parameters assessed in a 1-mm-thick periosteal region of the cortex rather than throughout the whole cortex. The observed moderate correlation between SOS and C.Th values (R2SOS/C.Th = 0.20, p < 10−2) disappeared when controlled for other variables. The two best multilinear predictive models, including either BMD alone or the pair of dependent variables MIN and POR (all assessed in the periosteal cortex), were equally accurate in predicting SOS values (R2SOS/(POR,MIN) = 0.59, p < 10−5; R2SOS/vBMD = 0.57, p < 10−5). Conclusion: For the first time, the respective adjusted contributions of POR (−24 m/s%−1) and tissue mineralization (+3.5 m/s/mg/cm−3) to SOS values were assessed. These results suggest potential sensitivity of axial transmission SOS values to changes in cortical bone status under different pathological conditions or treatments affecting POR and/or tissue mineralization.
Document Type: Article
Language: English
ISSN: 1523-4681
0884-0431
DOI: 10.1359/jbmr.040513
Access URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/JBMR.040513
https://pubmed.ncbi.nlm.nih.gov/15312257
https://onlinelibrary.wiley.com/doi/abs/10.1359/JBMR.040513
https://hal.archives-ouvertes.fr/hal-00109675
https://europepmc.org/article/MED/15312257
https://onlinelibrary.wiley.com/doi/full/10.1359/JBMR.040513
https://www.ncbi.nlm.nih.gov/pubmed/15312257
https://hal.science/hal-00109675v1
https://doi.org/10.1359/jbmr.040513
Rights: OUP Standard Publication Reuse
Accession Number: edsair.doi.dedup.....a9f32b98a4f9ba66a6ffc3009e3ef2d3
Database: OpenAIRE
Description
Abstract:The ultrasonic axial transmission technique allows for investigating skeletal sites such as the cortical layer of long bones (radius, tibia, phalanges). Using synchrotron radiation μCT, we investigated, in vitro, the relationships between 1-MHz axial transmission SOS measurements at the radius and site-matched measurements of C.Th, POR, MIN, and vBMD. Introduction: The ultrasonic axial transmission technique allows for investigating skeletal sites such as the cortical layer of long bones (radius, tibia, phalanges). Materials and Methods:Using synchrotron radiation μCT, we investigated, in vitro, the relationships between 1-MHz axial transmission speed of sound (SOS) measurements at the radius and site-matched measurements of cortical thickness (C.Th), intracortical porosity (POR), tissue mineralization (MIN), and volumetric BMD (vBMD). SOS measurements were based on bidirectional axial transmission and were performed with a 1-MHz proprietary probe on 39 excised human radii. Results: The highest correlations between SOS values and bone parameters (R2SOS/POR = 0.28, p < 10−3; R2SOS/MIN = 0.38, p < 10−4; R2SOS/vBMD = 0.57, p < 10−3) were found for bone parameters assessed in a 1-mm-thick periosteal region of the cortex rather than throughout the whole cortex. The observed moderate correlation between SOS and C.Th values (R2SOS/C.Th = 0.20, p < 10−2) disappeared when controlled for other variables. The two best multilinear predictive models, including either BMD alone or the pair of dependent variables MIN and POR (all assessed in the periosteal cortex), were equally accurate in predicting SOS values (R2SOS/(POR,MIN) = 0.59, p < 10−5; R2SOS/vBMD = 0.57, p < 10−5). Conclusion: For the first time, the respective adjusted contributions of POR (−24 m/s%−1) and tissue mineralization (+3.5 m/s/mg/cm−3) to SOS values were assessed. These results suggest potential sensitivity of axial transmission SOS values to changes in cortical bone status under different pathological conditions or treatments affecting POR and/or tissue mineralization.
ISSN:15234681
08840431
DOI:10.1359/jbmr.040513