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Prevalence of Patients Admitted to Intensive Care After Administration of Chlordiazepoxide in the Emergency Room

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Název: Prevalence of Patients Admitted to Intensive Care After Administration of Chlordiazepoxide in the Emergency Room
Autoři: Jakob Nørgaard Henriksen, Sara Buttrup Rosenquist, Dorte Goldbækdal Illum, Charlotte Uggerhøj Andersen
Zdroj: Basic Clin Pharmacol Toxicol
Henriksen, J N, Rosenquist, S B, Illum, D G & Andersen, C U 2025, 'Prevalence of Patients Admitted to Intensive Care After Administration of Chlordiazepoxide in the Emergency Room', Basic & Clinical Pharmacology & Toxicology, vol. 136, no. 4, e70018. https://doi.org/10.1111/bcpt.70018
Informace o vydavateli: Wiley, 2025.
Rok vydání: 2025
Témata: Male, Adult, Flumazenil, Critical Care, liver cirrhosis, Hypnotics and Sedatives/adverse effects, Patient Admission/statistics & numerical data, chlordiazepoxide, Patient Admission, Chlordiazepoxide/administration & dosage, Risk Factors, Prevalence, Humans, Hypnotics and Sedatives, abstinence, Retrospective Studies, Aged, Aged, 80 and over, Substance Withdrawal Syndrome/epidemiology, alcoholism, Critical Care/methods, Flumazenil/therapeutic use, Chlordiazepoxide, Middle Aged, Length of Stay, Substance Withdrawal Syndrome, poisoning, Intensive Care Units, Cross-Sectional Studies, Emergency Service, Hospital/statistics & numerical data, Intensive Care Units/statistics & numerical data, Original Article, Female, Emergency Service, Hospital
Popis: Chlordiazepoxide is effective in treating alcohol withdrawal syndrome, but it poses a risk of long‐term sedation. The prevalence of this side effect and its risk factors remain uncertain. This retrospective cross‐sectional study aimed to estimate both using data from Aarhus University Hospital's BI portal. We identified and manually reviewed patient records from 1 September 2019 to 31 August 2021, including the treating physicians' conclusions on ICU admissions to determine whether they were likely due to chlordiazepoxide toxicity. Chlordiazepoxide was administered to 1363 unique patients in the study period. We identified 32 ICU admissions preceded by chlordiazepoxide administration, 5 of which (16%) were likely related to chlordiazepoxide toxicity. Patients with chlordiazepoxide‐induced admissions received higher cumulative doses compared to other admissions (425 mg vs. 150 mg, p = 0.01), had longer ICU stays (median 8 vs. 2 days, p = 0.01) and required higher doses of flumazenil (p = 0.04). Their median age was above 60 years, and not all had known liver disease. The overall incidence of long‐term chlordiazepoxide toxicity was approximately 0.35%, with risk factors including higher doses and age above 60. Our findings suggest increased caution when treating not only patients with liver disease but also elderly patients with chlordiazepoxide for alcohol withdrawal symptoms.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1742-7843
1742-7835
DOI: 10.1111/bcpt.70018
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40070362
http://www.scopus.com/inward/record.url?scp=105000109958&partnerID=8YFLogxK
https://pure.au.dk/portal/en/publications/b1482a8a-2762-4cfb-9bd3-74cb3946e8a3
https://doi.org/10.1111/bcpt.70018
Rights: CC BY NC ND
URL: http://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Přístupové číslo: edsair.doi.dedup.....a8a841d309594b16ac211bc08c0547cc
Databáze: OpenAIRE
Popis
Abstrakt:Chlordiazepoxide is effective in treating alcohol withdrawal syndrome, but it poses a risk of long‐term sedation. The prevalence of this side effect and its risk factors remain uncertain. This retrospective cross‐sectional study aimed to estimate both using data from Aarhus University Hospital's BI portal. We identified and manually reviewed patient records from 1 September 2019 to 31 August 2021, including the treating physicians' conclusions on ICU admissions to determine whether they were likely due to chlordiazepoxide toxicity. Chlordiazepoxide was administered to 1363 unique patients in the study period. We identified 32 ICU admissions preceded by chlordiazepoxide administration, 5 of which (16%) were likely related to chlordiazepoxide toxicity. Patients with chlordiazepoxide‐induced admissions received higher cumulative doses compared to other admissions (425 mg vs. 150 mg, p = 0.01), had longer ICU stays (median 8 vs. 2 days, p = 0.01) and required higher doses of flumazenil (p = 0.04). Their median age was above 60 years, and not all had known liver disease. The overall incidence of long‐term chlordiazepoxide toxicity was approximately 0.35%, with risk factors including higher doses and age above 60. Our findings suggest increased caution when treating not only patients with liver disease but also elderly patients with chlordiazepoxide for alcohol withdrawal symptoms.
ISSN:17427843
17427835
DOI:10.1111/bcpt.70018