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Efficacy and Safety of Probiotics for Dental Caries in Preschool Children: A Systematic Review and Meta-analysis

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Title: Efficacy and Safety of Probiotics for Dental Caries in Preschool Children: A Systematic Review and Meta-analysis
Authors: Aarati S Panchbhai, Mahalaqua Nazli Khatib, Rajiv M Borle, Shravani S Deolia, Vijay M Babar, Anjali H Vasistha, Ritika P Parida
Source: Contemp Clin Dent
Contemporary Clinical Dentistry, Vol 15, Iss 1, Pp 10-16 (2024)
Publisher Information: Medknow, 2024.
Publication Year: 2024
Subject Terms: 0301 basic medicine, cariogenic microorganism, 0303 health sciences, RK1-715, Systematic Review Article, decayed, missing, early carious lesions, streptococcus mutans, 3. Good health, lactobacillus, 03 medical and health sciences, probiotics, Dentistry, and filled teeth/dmft index, dental caries
Description: Background: Early childhood caries is one of the most serious and high-priced oral health conditions among young children. With advancing dental sciences, the focus of dental caries treatment is shifted from restorative procedures to preventive measures, and a modality grabbing attention is probiotics. Probiotics exert their effects in many ways as chemical inhibition of pathogenic bacteria and stimulation of the immune response through the production of immunoglobulin A and many more. Objective: This systematic review aims to explore the efficacy and safety of probiotics in dental caries in preschool children. Methodology: The study was registered in the PROSPERO International Prospective Register of Systematic Reviews (registration number: CRD42020159058). The search was done for randomized control trials in electronic databases such as Cochrane, PubMed, ClinicalTrials.gov, Medline, and Embase. It has further included manual searches of journals, conference abstracts, and books. Three reviewers done the selection of the study as per the criteria and also did the risk of bias assessment independently and wherever required, a fourth reviewer resolved the discrepancy in case of disagreement. Results: The nine randomized control trials were included in the study, and the pooled analysis revealed probiotics as an effective intervention in preschool children with dental caries. Conclusion: The results about the efficacy of probiotics in the prevention of dental caries are very encouraging, though the level of evidence is still inadequate.
Document Type: Article
Other literature type
Language: English
ISSN: 0976-2361
0976-237X
DOI: 10.4103/ccd.ccd_40_23
Access URL: https://pubmed.ncbi.nlm.nih.gov/38707673
https://doaj.org/article/32d87aa68b384a78bb48fde56105a248
Rights: URL: http://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
Accession Number: edsair.doi.dedup.....a85fab9e7719e3bdf32c59d8c745fdaf
Database: OpenAIRE
Description
Abstract:Background: Early childhood caries is one of the most serious and high-priced oral health conditions among young children. With advancing dental sciences, the focus of dental caries treatment is shifted from restorative procedures to preventive measures, and a modality grabbing attention is probiotics. Probiotics exert their effects in many ways as chemical inhibition of pathogenic bacteria and stimulation of the immune response through the production of immunoglobulin A and many more. Objective: This systematic review aims to explore the efficacy and safety of probiotics in dental caries in preschool children. Methodology: The study was registered in the PROSPERO International Prospective Register of Systematic Reviews (registration number: CRD42020159058). The search was done for randomized control trials in electronic databases such as Cochrane, PubMed, ClinicalTrials.gov, Medline, and Embase. It has further included manual searches of journals, conference abstracts, and books. Three reviewers done the selection of the study as per the criteria and also did the risk of bias assessment independently and wherever required, a fourth reviewer resolved the discrepancy in case of disagreement. Results: The nine randomized control trials were included in the study, and the pooled analysis revealed probiotics as an effective intervention in preschool children with dental caries. Conclusion: The results about the efficacy of probiotics in the prevention of dental caries are very encouraging, though the level of evidence is still inadequate.
ISSN:09762361
0976237X
DOI:10.4103/ccd.ccd_40_23