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Severe Liver‐Related Outcomes in Patients With Hepatitis Delta: Results From a Multi‐Ethnic Multicenter Long‐Term Follow‐Up Study

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Title: Severe Liver‐Related Outcomes in Patients With Hepatitis Delta: Results From a Multi‐Ethnic Multicenter Long‐Term Follow‐Up Study
Authors: Furquim d'Almeida, Arno, Ho, Erwin, Govaerts, Liesbeth, Michielsen, Peter, Sersté, Thomas, Bourgeois, Stefan, Delwaide, Jean, Moreno, Christophe, Orlent, Hans, Van Vlierberghe, Hans, de Galocsy, Chantal, Peeters, Michael, Padalko, Elizaveta, Van Gucht, Steven, Vanwolleghem, Thomas
Source: J Viral Hepat
Journal of viral hepatitis
JOURNAL OF VIRAL HEPATITIS
Publisher Information: Wiley, 2025.
Publication Year: 2025
Subject Terms: HBV‐HDV coinfection, Male, Liver Cirrhosis, Adult, Hepatitis D, Chronic, Coinfection/virology, HBV-HDV coinfection, viral hepatitis, Sciences de la santé humaine, Severity of Illness Index, Hepatitis B, Chronic, hepatitis delta virus, Risk Factors, Virology, Medicine and Health Sciences, Ethnicity, EPIDEMIOLOGY, Humans, Hepatitis Antibodies, Hepatitis D, Chronic/complications, RNA, Viral/blood, Human health sciences, Retrospective Studies, Aged, viremia, Hepatitis B Surface Antigens, Hepatology, Coinfection, Gastroentérologie & hépatologie, Middle Aged, Hepatitis D, Hepatitis Delta Virus/genetics, Infectious Diseases, Liver Cirrhosis/virology, DNA, Viral, Disease Progression, VIRUS, RNA, Viral, Original Article, Female, Human medicine, Hepatitis Delta Virus, Hepatitis D/epidemiology, hepatitis B virus, Gastroenterology & hepatology, Hepatitis Antibodies/blood, Follow-Up Studies
Description: Hepatitis B virus (HBV)–hepatitis delta virus (HDV) coinfection is the most severe form of chronic viral hepatitis, but the factors that determine disease progression and severity are incompletely characterised. This long‐term follow‐up study aims to identify risk factors for severe liver‐related outcomes. In this multicentre national cohort study, data from admission until the last visit between 2001 and 2023 was retrospectively collected from 162 HBV‐HDV coinfected patients. The inclusion criteria were HBsAg or HBV DNA positivity, anti‐HDV or HDV RNA positivity, and at least one follow‐up visit. The median follow‐up was 6.2 years (IQR 3.3–10.2). At baseline, 68/152 (44.7%) patients were diagnosed with advanced liver fibrosis. Forty patients (24.7%) had at least one severe liver‐related outcome during follow‐up. HDV viremia was detectable in 92 patients (64.3%) at last evaluation and was more frequently detectable in patients of European origin (p p p = 0.007) compared to HDV RNA‐negative patients. Multivariate analyses identified HDV RNA positivity, as well as several markers for liver disease severity, such as INR, platelet count, and advanced fibrosis at baseline, and age at admission as independent risk factors for severe liver‐related outcomes. In conclusion, almost one in four HBV‐HDV coinfected patients developed a severe liver‐related outcome during follow‐up. Several markers for liver disease severity and HDV RNA positivity were the strongest predictors for outcomes.
Document Type: Article
Other literature type
File Description: application/pdf
Language: English
ISSN: 1365-2893
1352-0504
DOI: 10.1111/jvh.14060
Access URL: https://pubmed.ncbi.nlm.nih.gov/39846497
https://repository.uantwerpen.be/docstore/d:irua:27560
https://hdl.handle.net/10067/2116580151162165141
http://hdl.handle.net/1854/LU-01JKQAC5EY5KGSK5SG6AB1R7MN
https://biblio.ugent.be/publication/01JKQAC5EY5KGSK5SG6AB1R7MN
http://doi.org/10.1111/jvh.14060
https://biblio.ugent.be/publication/01JKQAC5EY5KGSK5SG6AB1R7MN/file/01JKQACZX8F8AYE226MH4AA36Z
Rights: CC BY NC ND
URL: http://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Accession Number: edsair.doi.dedup.....a81235c16ee9065e4ac75fe020625554
Database: OpenAIRE
Description
Abstract:Hepatitis B virus (HBV)–hepatitis delta virus (HDV) coinfection is the most severe form of chronic viral hepatitis, but the factors that determine disease progression and severity are incompletely characterised. This long‐term follow‐up study aims to identify risk factors for severe liver‐related outcomes. In this multicentre national cohort study, data from admission until the last visit between 2001 and 2023 was retrospectively collected from 162 HBV‐HDV coinfected patients. The inclusion criteria were HBsAg or HBV DNA positivity, anti‐HDV or HDV RNA positivity, and at least one follow‐up visit. The median follow‐up was 6.2 years (IQR 3.3–10.2). At baseline, 68/152 (44.7%) patients were diagnosed with advanced liver fibrosis. Forty patients (24.7%) had at least one severe liver‐related outcome during follow‐up. HDV viremia was detectable in 92 patients (64.3%) at last evaluation and was more frequently detectable in patients of European origin (p p p = 0.007) compared to HDV RNA‐negative patients. Multivariate analyses identified HDV RNA positivity, as well as several markers for liver disease severity, such as INR, platelet count, and advanced fibrosis at baseline, and age at admission as independent risk factors for severe liver‐related outcomes. In conclusion, almost one in four HBV‐HDV coinfected patients developed a severe liver‐related outcome during follow‐up. Several markers for liver disease severity and HDV RNA positivity were the strongest predictors for outcomes.
ISSN:13652893
13520504
DOI:10.1111/jvh.14060