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Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode

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Title: Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode
Authors: T. Pakeerathan, J. Havla, C. Schwake, A. Salmen, S. Bigi, M. Abegg, D. Brügger, T. Ferrazzini, A.-K. Runge, M. Breu, B. Kornek, G. Bsteh, A. Felipe-Rucián, M. Ringelstein, O. Aktas, M. Karenfort, E. Wendel, I. Kleiter, K. Hellwig, T. Kümpfel, C. Thiels, T. Lücke, R. Gold, K. Rostasy, I. Ayzenberg
Contributors: Institut Català de la Salut, [Pakeerathan T, Schwake C] Department of Neurology, St. Josef-Hospital, RuhrUniversity Bochum, 44791 Bochum, Germany. [Havla J] Institute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians Universität München, Munich, Germany. Data Integration for Future Medicine (DIFUTURE) Consortium, LMU Hospital, Ludwig-Maximilians Universität München, Munich, Germany. [Salmen A] Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. [Bigi S] Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland. Division of Child Neurology, Department of Pediatrics, University Children’s Hospital Bern, University of Bern, Bern, Switzerland. [Abegg M] Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. [Felipe-Rucián A] Servei de Neurologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona
Source: J Neurol
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
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Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Pakeerathan, T; Havla, J; Schwake, C; Salmen, A; Bigi, S; Abegg, M; Brügger, D; Ferrazzini, T; Runge, A-K; Breu, M; Kornek, B; Bsteh, G; Felipe-Rucián, A; Ringelstein, M; Aktas, O; Karenfort, M; Wendel, E; Kleiter, I; Hellwig, K; Kümpfel, T; ... (2022). Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode. Journal of neurology, 269(12), pp. 6366-6376. Springer-Medizin-Verlag 10.1007/s00415-022-11256-y <http://dx.doi.org/10.1007/s00415-022-11256-y>
Publisher Information: Springer Science and Business Media LLC, 2022.
Publication Year: 2022
Subject Terms: Ulls - Tomografia, Optic Neuritis, Multiple Sclerosis, Pediatric patients, Vision Disorders, 610 Medicine & health, Optic neuritis, Esclerosi múltiple, DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis, Retina, MOGAD, Multiple sclerosis, 03 medical and health sciences, 0302 clinical medicine, 360 Social problems & social services, DISEASES::Eye Diseases::Eye Diseases::Retinal Diseases::Retinal Degeneration, Humans, Children, Retrospective Studies, ddc:610, Original Communication, Optical coherence tomography, Visual evoked potential, Retinal Degeneration, Retina - Malalties, ENFERMEDADES::oftalmopatías::oftalmopatías::enfermedades de la retina::degeneración retiniana, Myelin-oligodendrocyte-glycoprotein IgG, 3. Good health, ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::imágenes ópticas::tomografía óptica::tomografía de coherencia óptica, Atrophy, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Optical Imaging::Tomography, Optical::Tomography, Optical Coherence, Tomography, Optical Coherence
Description: Background Optic neuritis (ON) is the most prevalent manifestation of pediatric multiple sclerosis (MSped) and myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGADped) in children > 6 years. In this study, we investigated retinal atrophy patterns and diagnostic accuracy of optical coherence tomography (OCT) in differentiating between both diseases after the first ON episode. Methods Patients were retrospectively identified in eight tertial referral centers. OCT, VEP and high/low-contrast visual acuity (HCVA/LCVA) have been investigated > 6 months after the first ON. Prevalence of pathological OCT findings was identified based on data of 144 age-matched healthy controls. Results Thirteen MOGADped (10.7 ± 4.2 years, F:M 8:5, 21 ON eyes) and 21 MSped (14.3 ± 2.4 years, F:M 19:2, 24 ON eyes) patients were recruited. We observed a significantly more profound atrophy of both peripapillary and macular retinal nerve fiber layer in MOGADped compared to MSped (pRNFL global: 68.2 ± 16.9 vs. 89.4 ± 12.3 µm, p 3, p ped developed global atrophy affecting all peripapillary segments, while MSped displayed predominantly temporal thinning. Nasal pRNFL allowed differentiation between both diseases with the highest diagnostic accuracy (AUC = 0.902, cutoff ped). OCT was also substantially more sensitive compared to VEP in identification of ON eyes in MOGAD (pathological findings in 90% vs. 14%, p = 0.016). Conclusion First MOGAD-ON results in a more severe global peripapillary atrophy compared to predominantly temporal thinning in MS-ON. Nasal pRNFL allows differentiation between both diseases with the highest accuracy, supporting the additional diagnostic value of OCT in children with ON.
Document Type: Article
Other literature type
File Description: application/pdf
Language: English
ISSN: 1432-1459
0340-5354
DOI: 10.1007/s00415-022-11256-y
DOI: 10.48350/171555
Access URL: https://pubmed.ncbi.nlm.nih.gov/35869995
https://hdl.handle.net/11351/8406
https://boris.unibe.ch/171555/
https://nbn-resolving.org/urn:nbn:de:hbz:294-132652
https://hss-opus.ub.ruhr-uni-bochum.de/opus4/frontdoor/index/index/docId/13265
https://hss-opus.ub.ruhr-uni-bochum.de/opus4/files/13265/AyzenbergIlya.pdf
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) .
Accession Number: edsair.doi.dedup.....a6fa3487cd96dba4deadc3bd93955287
Database: OpenAIRE
Description
Abstract:Background Optic neuritis (ON) is the most prevalent manifestation of pediatric multiple sclerosis (MSped) and myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGADped) in children > 6 years. In this study, we investigated retinal atrophy patterns and diagnostic accuracy of optical coherence tomography (OCT) in differentiating between both diseases after the first ON episode. Methods Patients were retrospectively identified in eight tertial referral centers. OCT, VEP and high/low-contrast visual acuity (HCVA/LCVA) have been investigated > 6 months after the first ON. Prevalence of pathological OCT findings was identified based on data of 144 age-matched healthy controls. Results Thirteen MOGADped (10.7 ± 4.2 years, F:M 8:5, 21 ON eyes) and 21 MSped (14.3 ± 2.4 years, F:M 19:2, 24 ON eyes) patients were recruited. We observed a significantly more profound atrophy of both peripapillary and macular retinal nerve fiber layer in MOGADped compared to MSped (pRNFL global: 68.2 ± 16.9 vs. 89.4 ± 12.3 µm, p 3, p ped developed global atrophy affecting all peripapillary segments, while MSped displayed predominantly temporal thinning. Nasal pRNFL allowed differentiation between both diseases with the highest diagnostic accuracy (AUC = 0.902, cutoff ped). OCT was also substantially more sensitive compared to VEP in identification of ON eyes in MOGAD (pathological findings in 90% vs. 14%, p = 0.016). Conclusion First MOGAD-ON results in a more severe global peripapillary atrophy compared to predominantly temporal thinning in MS-ON. Nasal pRNFL allows differentiation between both diseases with the highest accuracy, supporting the additional diagnostic value of OCT in children with ON.
ISSN:14321459
03405354
DOI:10.1007/s00415-022-11256-y