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Multiple Strain Colonization and Metronidazole Resistance in Helicobacter pylori-Infected Patients: Identification from Sequential and Multiple Biopsy Specimens

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Bibliographic Details
Title: Multiple Strain Colonization and Metronidazole Resistance in Helicobacter pylori-Infected Patients: Identification from Sequential and Multiple Biopsy Specimens
Authors: Jorgensen, M., Daskalopoulos, G., Warburton, V., Mitchell, H. M., Hazell, S. L.
Source: Journal of Infectious Diseases. 174:631-635
Publisher Information: Oxford University Press (OUP), 1996.
Publication Year: 1996
Subject Terms: DNA, Bacterial, 0301 basic medicine, 0303 health sciences, Drug Resistance, Microbial/genetics, Helicobacter pylori, Biopsy, Stomach, Genetic Variation, Drug Resistance, Microbial, Polymerase Chain Reaction, Helicobacter Infections, 3. Good health, 03 medical and health sciences, Helicobacter Infections/*drug therapy, Metronidazole, Humans, DNA, Bacterial/analysis, Stomach/microbiology, Helicobacter pylori/*genetics/growth & development, Metronidazole/*therapeutic use
Description: Helicobacter pylori strain diversity was investigated in infected persons by collection of multiple biopsies before and after therapy failure. It was demonstrated by random amplification of polymorphic DNA polymerase chain reaction that patients may be infected with a mixed population of H. pylori strains. Most patients were colonized with a predominant strain accompanied by up to 5 variant strains. The use of antimicrobials resulted in an altered distribution of the strains present, but the predominant strain usually remained. Patients may be infected with a mixed population of metronidazole-sensitive and -resistant strains at one time, with metronidazole-based therapy selectively enriching for a resistant population.
Document Type: Article
Language: English
ISSN: 1537-6613
0022-1899
DOI: 10.1093/infdis/174.3.631
Access URL: https://academic.oup.com/jid/article-pdf/174/3/631/2679782/174-3-631.pdf
https://pubmed.ncbi.nlm.nih.gov/8769626
https://academic.oup.com/jid/article/174/3/631/902769
https://paperity.org/p/58707027/multiple-strain-colonization-and-metronidazole-resistance-in-helicobacter-pylori-infected
https://www.ncbi.nlm.nih.gov/pubmed/8769626
https://europepmc.org/article/MED/8769626
https://pubmed.ncbi.nlm.nih.gov/8769626/
http://olympias.lib.uoi.gr/jspui/handle/123456789/19857
Accession Number: edsair.doi.dedup.....a6b51ff225ee839e83373a2665d3de1c
Database: OpenAIRE
Description
Abstract:Helicobacter pylori strain diversity was investigated in infected persons by collection of multiple biopsies before and after therapy failure. It was demonstrated by random amplification of polymorphic DNA polymerase chain reaction that patients may be infected with a mixed population of H. pylori strains. Most patients were colonized with a predominant strain accompanied by up to 5 variant strains. The use of antimicrobials resulted in an altered distribution of the strains present, but the predominant strain usually remained. Patients may be infected with a mixed population of metronidazole-sensitive and -resistant strains at one time, with metronidazole-based therapy selectively enriching for a resistant population.
ISSN:15376613
00221899
DOI:10.1093/infdis/174.3.631