Multiple Strain Colonization and Metronidazole Resistance in Helicobacter pylori-Infected Patients: Identification from Sequential and Multiple Biopsy Specimens
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| Titel: | Multiple Strain Colonization and Metronidazole Resistance in Helicobacter pylori-Infected Patients: Identification from Sequential and Multiple Biopsy Specimens |
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| Autoren: | Jorgensen, M., Daskalopoulos, G., Warburton, V., Mitchell, H. M., Hazell, S. L. |
| Quelle: | Journal of Infectious Diseases. 174:631-635 |
| Verlagsinformationen: | Oxford University Press (OUP), 1996. |
| Publikationsjahr: | 1996 |
| Schlagwörter: | DNA, Bacterial, 0301 basic medicine, 0303 health sciences, Drug Resistance, Microbial/genetics, Helicobacter pylori, Biopsy, Stomach, Genetic Variation, Drug Resistance, Microbial, Polymerase Chain Reaction, Helicobacter Infections, 3. Good health, 03 medical and health sciences, Helicobacter Infections/*drug therapy, Metronidazole, Humans, DNA, Bacterial/analysis, Stomach/microbiology, Helicobacter pylori/*genetics/growth & development, Metronidazole/*therapeutic use |
| Beschreibung: | Helicobacter pylori strain diversity was investigated in infected persons by collection of multiple biopsies before and after therapy failure. It was demonstrated by random amplification of polymorphic DNA polymerase chain reaction that patients may be infected with a mixed population of H. pylori strains. Most patients were colonized with a predominant strain accompanied by up to 5 variant strains. The use of antimicrobials resulted in an altered distribution of the strains present, but the predominant strain usually remained. Patients may be infected with a mixed population of metronidazole-sensitive and -resistant strains at one time, with metronidazole-based therapy selectively enriching for a resistant population. |
| Publikationsart: | Article |
| Sprache: | English |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/174.3.631 |
| Zugangs-URL: | https://academic.oup.com/jid/article-pdf/174/3/631/2679782/174-3-631.pdf https://pubmed.ncbi.nlm.nih.gov/8769626 https://academic.oup.com/jid/article/174/3/631/902769 https://paperity.org/p/58707027/multiple-strain-colonization-and-metronidazole-resistance-in-helicobacter-pylori-infected https://www.ncbi.nlm.nih.gov/pubmed/8769626 https://europepmc.org/article/MED/8769626 https://pubmed.ncbi.nlm.nih.gov/8769626/ http://olympias.lib.uoi.gr/jspui/handle/123456789/19857 |
| Dokumentencode: | edsair.doi.dedup.....a6b51ff225ee839e83373a2665d3de1c |
| Datenbank: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | Helicobacter pylori strain diversity was investigated in infected persons by collection of multiple biopsies before and after therapy failure. It was demonstrated by random amplification of polymorphic DNA polymerase chain reaction that patients may be infected with a mixed population of H. pylori strains. Most patients were colonized with a predominant strain accompanied by up to 5 variant strains. The use of antimicrobials resulted in an altered distribution of the strains present, but the predominant strain usually remained. Patients may be infected with a mixed population of metronidazole-sensitive and -resistant strains at one time, with metronidazole-based therapy selectively enriching for a resistant population. |
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| ISSN: | 15376613 00221899 |
| DOI: | 10.1093/infdis/174.3.631 |