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A characterization of the HIV population with limited/exhausted treatment options: a multicenter Belgian study: a multicenter Belgian study

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Title: A characterization of the HIV population with limited/exhausted treatment options: a multicenter Belgian study: a multicenter Belgian study
Authors: Nasreddine, Rakan, Darcis, Gilles, Yombi, Jean Cyr, De Munter, Paul, Florence, Eric, Van Praet, Jens, Demeester, Rémy, Allard, Sabine D, Schroeder, Melanie, Dusabineza, Ange-Clarisse, Delforge, Marc, De Wit, Stéphane
Contributors: ViiV Healthcare, Brussels Photonics, Vitality Research Group, Clinical sciences, Internal Medicine
Source: Acta Clinica Belgica. 79:153-159
Publisher Information: Informa UK Limited, 2024.
Publication Year: 2024
Subject Terms: Male, Adult, Anti-HIV Agents, HIV Infections/drug therapy, limited/exhausted treatment options, HIV Infections, Sciences de la santé humaine, Immunologie & maladie infectieuse, extensive treatment history, Belgium, Prevalence, Humans, Viral load, Immunology & infectious disease, Human health sciences, Belgium/epidemiology, Medicine (all), HIV, Middle Aged, Viral Load, multi-drug resistant HIV-1, CD4 Lymphocyte Count, Cross-Sectional Studies, Anti-HIV Agents/therapeutic use, HIV Infections/epidemiology, HIV-1, Female
Description: Describe the prevalence and characteristics of people living with HIV (PLWH) in Belgium with limited/exhausted treatment options.A cross-sectional, multicenter study involving adult treatment-experienced individuals with limited/exhausted treatment options defined as having a multi-drug resistant HIV-1 or a history of multiple treatment changes. The primary outcome was to determine the prevalence of these individuals and classify them based on their two most recent consecutive HIV-1 viral loads (VLs): suppressed (2 VLs 200 copies/mL). Secondary outcome was to characterize the participants included in this analysis.There were 119 individuals included (prevalence of 0.97%; 119 of 12 282 in care). The majority were aged > 50 years (88.2%), women represented 35.3%, and individuals were primarily White (54.7%). Median (IQR) CD4+ T-cell count was 635 (400-875) cells/µL and most (42%) were on a 3-drug ART regimen. Overall, 87.4% were classified as suppressed, 9.2% as intermediate, and 3.4% as unsuppressed. On multivariable analysis, CD4+ T-cell count
Document Type: Article
Language: English
ISSN: 2295-3337
1784-3286
DOI: 10.1080/17843286.2024.2359184
Access URL: https://pubmed.ncbi.nlm.nih.gov/38813800
https://biblio.vub.ac.be/vubir/(231c772d-2d15-4319-b2de-b05570bb7fc5).html
Accession Number: edsair.doi.dedup.....a62f2d036869f77ab81263932f17ef12
Database: OpenAIRE
Description
Abstract:Describe the prevalence and characteristics of people living with HIV (PLWH) in Belgium with limited/exhausted treatment options.A cross-sectional, multicenter study involving adult treatment-experienced individuals with limited/exhausted treatment options defined as having a multi-drug resistant HIV-1 or a history of multiple treatment changes. The primary outcome was to determine the prevalence of these individuals and classify them based on their two most recent consecutive HIV-1 viral loads (VLs): suppressed (2 VLs 200 copies/mL). Secondary outcome was to characterize the participants included in this analysis.There were 119 individuals included (prevalence of 0.97%; 119 of 12 282 in care). The majority were aged > 50 years (88.2%), women represented 35.3%, and individuals were primarily White (54.7%). Median (IQR) CD4+ T-cell count was 635 (400-875) cells/µL and most (42%) were on a 3-drug ART regimen. Overall, 87.4% were classified as suppressed, 9.2% as intermediate, and 3.4% as unsuppressed. On multivariable analysis, CD4+ T-cell count
ISSN:22953337
17843286
DOI:10.1080/17843286.2024.2359184