Topical and systemic antibiotics in the management of periodontal diseases
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| Název: | Topical and systemic antibiotics in the management of periodontal diseases |
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| Autoři: | Mombelli, A, Samaranayake, LP |
| Zdroj: | International Dental Journal. 54:3-14 |
| Informace o vydavateli: | Elsevier BV, 2004. |
| Rok vydání: | 2004 |
| Témata: | Locally Delivered Doxycycline, Oral, Actinomycetemcomitans-Associated Periodontitis, Administration, Topical, periodontal disease, Administration, Oral, Chlorhexidine - administration & dosage - analogs & derivatives, Aggregatibacter actinomycetemcomitans, antibiotics, Localized Juvenile Periodontitis, 03 medical and health sciences, Actinobacillus Infections, 0302 clinical medicine, Anti-Infective Agents, Actinobacillus-Actinomycetemcomitans, Metronidazole, Gram-Negative Bacteria, Bacteroidaceae Infections - drug therapy, Anti-Bacterial Agents - administration & dosage, Bacteroidaceae Infections, Humans, Periodontitis, Tetracycline Fiber Therapy, Periodontitis - drug therapy - microbiology, Actinobacillus Infections - drug therapy, Chlorhexidine, Actinobacillus actinomycetemcomitans - drug effects, systemic, Porphyromonas gingivalis - drug effects, Tetracycline, Bacteroides-Intermedius, High-Risk Patients, Anti-Bacterial Agents, 3. Good health, Topical, Tetracycline - administration & dosage, Adult Periodontitis, Administration, Anti-Infective Agents, Local, Multicenter Evaluation, Local - administration & dosage, Anti-Infective Agents, Local - administration & dosage, Metronidazole - administration & dosage, Porphyromonas gingivalis, local delivery |
| Popis: | Both systemic and topical antibiotics are increasingly used in the management of periodontal infections. Whilst these drugs are used mostly on an empirical basis, some contend that rational use of antibiotics should be the norm due to their wide abuse and consequential global emergence of antibiotic resistance organisms. Here we review the rationale and principles of antimicrobial therapy, treatment goals, drug delivery routes and various antibiotics that are used in the management of periodontal diseases. The pros and cons of systemic and local antibiotic therapy are described together with practical guidelines for their delivery. The available data indicate, in general, that mechanical periodontal treatment alone is adequate to ameliorate or resolve the clinical condition in most cases, but adjunctive antimicrobial agents, delivered either locally or systemically, can enhance the effect of therapy in specific situations. This is particularly true for aggressive (early onset) periodontitis, in patients with generalised systemic disease that may affect host resistance and in case of poor response to conventional mechanical therapy. Locally delivered antibiotics together with mechanical debridement are indicated for non-responding sites of focal infection or in localised recurrent disease. After resolution of the periodontal infection, the patient should be placed on an individually tailored maintenance care programme. Optimal plaque control by the patient is of paramount importance for a favourable clinical and microbiological response to any form of periodontal therapy. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 0020-6539 |
| DOI: | 10.1111/j.1875-595x.2004.tb00246.x |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/15005467 http://europepmc.org/abstract/MED/15005467 https://www.sciencedirect.com/science/article/pii/S0020653920350267 https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1875-595X.2004.tb00246.x https://www.ncbi.nlm.nih.gov/pubmed/15005467 https://espace.library.uq.edu.au/view/UQ:322689 http://hdl.handle.net/10722/67097 |
| Rights: | Elsevier Non-Commercial |
| Přístupové číslo: | edsair.doi.dedup.....a5f0e9f7ba90704c142dba3786025c65 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Both systemic and topical antibiotics are increasingly used in the management of periodontal infections. Whilst these drugs are used mostly on an empirical basis, some contend that rational use of antibiotics should be the norm due to their wide abuse and consequential global emergence of antibiotic resistance organisms. Here we review the rationale and principles of antimicrobial therapy, treatment goals, drug delivery routes and various antibiotics that are used in the management of periodontal diseases. The pros and cons of systemic and local antibiotic therapy are described together with practical guidelines for their delivery. The available data indicate, in general, that mechanical periodontal treatment alone is adequate to ameliorate or resolve the clinical condition in most cases, but adjunctive antimicrobial agents, delivered either locally or systemically, can enhance the effect of therapy in specific situations. This is particularly true for aggressive (early onset) periodontitis, in patients with generalised systemic disease that may affect host resistance and in case of poor response to conventional mechanical therapy. Locally delivered antibiotics together with mechanical debridement are indicated for non-responding sites of focal infection or in localised recurrent disease. After resolution of the periodontal infection, the patient should be placed on an individually tailored maintenance care programme. Optimal plaque control by the patient is of paramount importance for a favourable clinical and microbiological response to any form of periodontal therapy. |
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| ISSN: | 00206539 |
| DOI: | 10.1111/j.1875-595x.2004.tb00246.x |