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Association Between Caffeine Intake and Bowel Habits and Inflammatory Bowel Disease: A Population-Based Study

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Název: Association Between Caffeine Intake and Bowel Habits and Inflammatory Bowel Disease: A Population-Based Study
Autoři: Yang X, Yan H, Chen Y, Guo R
Zdroj: J Multidiscip Healthc
Journal of Multidisciplinary Healthcare, Vol Volume 18, Iss Issue 1, Pp 3717-3726 (2025)
Informace o vydavateli: Informa UK Limited, 2025.
Rok vydání: 2025
Témata: Medicine (General), R5-920, Chronic constipation, U-shaped, NHANES, Caffeine intake, Chronic diarrhea, Original Research
Popis: BACKGROUND: The effect of caffeine in coffee, a popular beverage, on gastrointestinal symptoms has been the subject of ongoing debate worldwide. The present study explored the association between caffeine intake and bowel habits and Inflammatory bowel disease (IBD). METHODS: Data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005–2010 were utilized for this cross-sectional survey. Bowel habits and IBD were defined by self-report. Logistic regression models assessed the linear relationship between caffeine intake and chronic constipation. Nonlinear associations were delineated using fitted smoothed curves and threshold effect analyses. Finally, subgroup analyses and interactions were used to test the stability of the findings. RESULTS: This population-based study included a total of 12,759 adults. We found that caffeine intake was negatively associated with chronic diarrhea. There was a U-shaped nonlinear relationship between caffeine intake and chronic constipation. To the left of breakpoint 2.04 (100 mg/1 unit), caffeine intake was negatively associated with chronic constipation (OR [95% CI]: 0.82 [0.74, 0.90]), however, to the right of the breakpoint, there was a positive association (OR [95% CI]: 1.06 [1.00, 1.12]). In addition, no significant association was found between caffeine intake and IBD. Subgroup analyses and interaction tests showed that caffeine intake was simply negatively associated with chronic constipation in older adults. CONCLUSION: In conclusion, moderate caffeine intake may help with bowel movements, but excessive caffeine intake may cause chronic constipation. Appropriate caffeine intake in older adults may help prevent chronic constipation. This suggests that in our clinical practice, we need to strategize caffeine intake according to the population’s defecation status.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1178-2390
DOI: 10.2147/jmdh.s512855
Přístupová URL adresa: https://doaj.org/article/e22721c02a9947c28d0573d0f2c4ce16
Rights: CC BY NC
URL: http://creativecommons.org/licenses/by-nc/4.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at http://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0/ (http://creativecommons.org/licenses/by-nc/4.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (http://www.dovepress.com/terms.php).
Přístupové číslo: edsair.doi.dedup.....a54ae3b9aeaa08866cff681f8e351335
Databáze: OpenAIRE
Popis
Abstrakt:BACKGROUND: The effect of caffeine in coffee, a popular beverage, on gastrointestinal symptoms has been the subject of ongoing debate worldwide. The present study explored the association between caffeine intake and bowel habits and Inflammatory bowel disease (IBD). METHODS: Data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005–2010 were utilized for this cross-sectional survey. Bowel habits and IBD were defined by self-report. Logistic regression models assessed the linear relationship between caffeine intake and chronic constipation. Nonlinear associations were delineated using fitted smoothed curves and threshold effect analyses. Finally, subgroup analyses and interactions were used to test the stability of the findings. RESULTS: This population-based study included a total of 12,759 adults. We found that caffeine intake was negatively associated with chronic diarrhea. There was a U-shaped nonlinear relationship between caffeine intake and chronic constipation. To the left of breakpoint 2.04 (100 mg/1 unit), caffeine intake was negatively associated with chronic constipation (OR [95% CI]: 0.82 [0.74, 0.90]), however, to the right of the breakpoint, there was a positive association (OR [95% CI]: 1.06 [1.00, 1.12]). In addition, no significant association was found between caffeine intake and IBD. Subgroup analyses and interaction tests showed that caffeine intake was simply negatively associated with chronic constipation in older adults. CONCLUSION: In conclusion, moderate caffeine intake may help with bowel movements, but excessive caffeine intake may cause chronic constipation. Appropriate caffeine intake in older adults may help prevent chronic constipation. This suggests that in our clinical practice, we need to strategize caffeine intake according to the population’s defecation status.
ISSN:11782390
DOI:10.2147/jmdh.s512855