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Albumin‐myosteatosis gauge as a novel prognostic risk factor in patients with non‐metastatic colorectal cancer

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Název: Albumin‐myosteatosis gauge as a novel prognostic risk factor in patients with non‐metastatic colorectal cancer
Autoři: Yerim Kim, Jae‐Hoon Lee, Eun‐Suk Cho, Hye Sun Lee, Su‐Jin Shin, Eun Jung Park, Seung Hyuk Baik, Kang Young Lee, Jeonghyun Kang
Přispěvatelé: Yerim Kim, Jae-Hoon Lee, Eun-Suk Cho, Hye Sun Lee, Su-Jin Shin, Eun Jung Park, Seung Hyuk Baik, Kang Young Lee, Jeonghyun Kang, Kang, Jeonghyun
Zdroj: J Cachexia Sarcopenia Muscle
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 2, Pp 860-868 (2023)
Informace o vydavateli: Wiley, 2023.
Rok vydání: 2023
Témata: Male, 0301 basic medicine, Sarcopenia, colorectal cancer, Diseases of the musculoskeletal system, sarcopenia, 03 medical and health sciences, Sarcopenia* / etiology, 0302 clinical medicine, Risk Factors, myosteatosis, Humans, albumin, Serum Albumin, Aged, albumin‐myosteatosis gauge, Inflammation, QM1-695, albumin-myosteatosis gauge, Original Articles, Colorectal Neoplasms* / pathology, Middle Aged, Prognosis, 3. Good health, RC925-935, inflammation, Human anatomy, Inflammation / complications, Female, Colorectal Neoplasms
Popis: BackgroundMyosteatosis and systemic inflammation are well‐known prognostic factors in patients with colorectal cancer (CRC). The serum albumin level is a reflection of malnutrition and systemic inflammation, which in turn plays a key role in the development of myosteatosis. However, few studies have been conducted on these synergistic effects. This study aimed to examine the individual and synergistic effects of different prognostic markers related to skeletal muscle quality and serum albumin levels in patients with CRC.MethodsThis study enrolled patients with stage I–III CRC who underwent surgical resection between July 2006 and February 2014. Skeletal muscle index (SMI) and skeletal muscle radiodensity (SMD) were calculated using computed tomography at the L3 level obtained within 2 months prior to surgery. The albumin‐myosteatosis gauge (AMG) was defined as SMD × albumin. Patients were divided into sex‐specific quartiles (G1 to G4) according to the AMG, and analysis of variance for continuous variables and chi‐square test for categorical variables were used to compare variables among quartiles. Cox proportional hazard models were constructed and integrated receiver operating characteristic curve (iAUC) analysis was used to compare the prognostic performance of SMD, albumin and AMG.ResultsAmong the 906 participants, the median (interquartile) age was 64 (55–72) years, and 365 (40.3%) were female. AMG was significantly correlated with the occurrence of complications, albumin level, SMI and SMD (all P P P = 0.045, G1 vs. G3, P = 0.005, G1 vs. G4, P ConclusionsIn patients with stage I–III CRC, AMG is a meaningful predictor of survival, with superior prognostic value compared to SMI, SMD or albumin alone. Further studies are needed to determine their significance in different ethnic groups.
Druh dokumentu: Article
Other literature type
Popis souboru: application/pdf
Jazyk: English
ISSN: 2190-6009
2190-5991
DOI: 10.1002/jcsm.13183
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/36696881
https://doaj.org/article/13fb9779c7a84bc49072d5f2219da8e9
Rights: CC BY NC ND
URL: http://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Přístupové číslo: edsair.doi.dedup.....a4bfba3c0d1a3dfcd182e29e5714edeb
Databáze: OpenAIRE
Popis
Abstrakt:BackgroundMyosteatosis and systemic inflammation are well‐known prognostic factors in patients with colorectal cancer (CRC). The serum albumin level is a reflection of malnutrition and systemic inflammation, which in turn plays a key role in the development of myosteatosis. However, few studies have been conducted on these synergistic effects. This study aimed to examine the individual and synergistic effects of different prognostic markers related to skeletal muscle quality and serum albumin levels in patients with CRC.MethodsThis study enrolled patients with stage I–III CRC who underwent surgical resection between July 2006 and February 2014. Skeletal muscle index (SMI) and skeletal muscle radiodensity (SMD) were calculated using computed tomography at the L3 level obtained within 2 months prior to surgery. The albumin‐myosteatosis gauge (AMG) was defined as SMD × albumin. Patients were divided into sex‐specific quartiles (G1 to G4) according to the AMG, and analysis of variance for continuous variables and chi‐square test for categorical variables were used to compare variables among quartiles. Cox proportional hazard models were constructed and integrated receiver operating characteristic curve (iAUC) analysis was used to compare the prognostic performance of SMD, albumin and AMG.ResultsAmong the 906 participants, the median (interquartile) age was 64 (55–72) years, and 365 (40.3%) were female. AMG was significantly correlated with the occurrence of complications, albumin level, SMI and SMD (all P P P = 0.045, G1 vs. G3, P = 0.005, G1 vs. G4, P ConclusionsIn patients with stage I–III CRC, AMG is a meaningful predictor of survival, with superior prognostic value compared to SMI, SMD or albumin alone. Further studies are needed to determine their significance in different ethnic groups.
ISSN:21906009
21905991
DOI:10.1002/jcsm.13183