Zobraziť v EDS

[Translated article] National survey and consensus document on dosing strategies for beta-lactam antibiotics against multidrug-resistant gram-negative bacilli (MDR-GNB) in critically ill patients undergoing extracorporeal life-support techniques: The DOSEBL study protocol

Uložené v:
Podrobná bibliografia
Názov: [Translated article] National survey and consensus document on dosing strategies for beta-lactam antibiotics against multidrug-resistant gram-negative bacilli (MDR-GNB) in critically ill patients undergoing extracorporeal life-support techniques: The DOSEBL study protocol
Autori: Pau-Parra, Alba, Núñez Núñez, María, Sadyrbaeva-Dolgova, Svetlana, Doménech Moral, Laura, Campelo Sánchez, Eva, Periañez Parraga, Leonor del Mar, Saeed Khan, Khalid, Luque Pardos, Sònia
Prispievatelia: Institut Català de la Salut, [Pau-Parra A, Doménech Moral L] Servei de Farmàcia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Núñez-Núñez M] Servicio de Farmacia, Hospital Universitario Clínico San Cecilio, Granada, Spain. Instituto de Investigación Biosanitaria de Granada (IBS-Granada), Granada, Spain. Centro de Investigación Biomédica en Epidemiología y Salud Púbica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. [Sadyrbaeva-Dolgova S] Servicio de Farmacia, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Campelo Sánchez E] Servicio de Farmacia, Hospital Álvaro Cunqueiro, Área Sanitaria Vigo, Vigo, Spain. [Periañez Parraga LM] Servicio de Farmacia, Hospital Universitario Son Espases, Mallorca, Spain, Vall d'Hebron Barcelona Hospital Campus
Zdroj: Digibug. Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname
Informácie o vydavateľovi: Elsevier BV, 2025.
Rok vydania: 2025
Predmety: ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Respiratory Therapy::Extracorporeal Membrane Oxygenation, Other subheadings::Other subheadings::Other subheadings::/drug therapy, ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias gramnegativas, Teràpia respiratòria, Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia, Lactames - Ús terapèutic, CHEMICALS AND DRUGS::Organic Chemicals::Amides::Lactams::beta-Lactams, Posologia, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia respiratoria::oxigenación por membrana extracorpórea, consenso, Beta-lactam antibiotics, Gram negativos, DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections, Farmacocinética, Decisió, Presa de, Otros calificadores::Otros calificadores::Otros calificadores::/administración & dosificación, Pharmacokinetics, Beta-lactámicos, Other subheadings::Other subheadings::Other subheadings::/administration & dosage, Malalties bacterianes gramnegatives - Tractament, PSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Psychology, Social::Group Processes::Consensus, COMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::amidas::lactamas::beta-lactamas, Gram negative bacteria
Popis: Infections caused by multidrug-resistant gram-negative bacilli (MDR-GNB) in critically ill patients present a challenge for timely and appropriate antibiotic treatment. This is particularly important in patients undergoing extracorporeal life-support techniques such as renal replacement therapy and extracorporeal membrane oxygenation. These techniques can introduce additional pharmacokinetic alterations, potentially leading to suboptimal exposure to antibiotics. This study aims to outline dosing strategies and therapeutic drug monitoring protocols for new β-lactam antibiotics effective against MDR-GNB in critically ill patients undergoing extracorporeal life-support techniques at a national level. Additionally, the study seeks to develop a consensus document, based on available evidence.The project will comprise two main phases: I) a national survey and II) the development of a consensus document. This consensus document, undertaken according to ACCORD guidelines, will encompass: a) establishment of a multidisciplinary panel of experts, b) prospective registration of the consensus, c) evidence synthesis, d) modified Delphi rounds. The antimicrobials to be included will be: meropenem, ceftazidime/avibactam, ceftolozane/tazobactam, cefiderocol, meropenem/vaborbactam, imipenem/relebactam, and aztreonam. Extracorporeal life-support techniques will include continuous renal replacement therapy, conventional intermittent hemodialysis, and extracorporeal membrane oxygenation.The availability of extracorporeal life-support techniques has expanded significantly in recent years, alongside a rise in the prevalence of infections caused by MDR-GNB. There is a need to develop evidence-based tools of high quality to standardize dosing and monitoring strategies for new β-lactam antibiotics.
Druh dokumentu: Article
Popis súboru: application/pdf
Jazyk: English
ISSN: 1130-6343
DOI: 10.1016/j.farma.2024.11.005
Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39675936
http://hdl.handle.net/11351/13095
https://hdl.handle.net/10481/104728
Rights: CC BY NC ND
Prístupové číslo: edsair.doi.dedup.....a3fcc9aba50e821ab0c2997b5cbaf347
Databáza: OpenAIRE
Popis
Abstrakt:Infections caused by multidrug-resistant gram-negative bacilli (MDR-GNB) in critically ill patients present a challenge for timely and appropriate antibiotic treatment. This is particularly important in patients undergoing extracorporeal life-support techniques such as renal replacement therapy and extracorporeal membrane oxygenation. These techniques can introduce additional pharmacokinetic alterations, potentially leading to suboptimal exposure to antibiotics. This study aims to outline dosing strategies and therapeutic drug monitoring protocols for new β-lactam antibiotics effective against MDR-GNB in critically ill patients undergoing extracorporeal life-support techniques at a national level. Additionally, the study seeks to develop a consensus document, based on available evidence.The project will comprise two main phases: I) a national survey and II) the development of a consensus document. This consensus document, undertaken according to ACCORD guidelines, will encompass: a) establishment of a multidisciplinary panel of experts, b) prospective registration of the consensus, c) evidence synthesis, d) modified Delphi rounds. The antimicrobials to be included will be: meropenem, ceftazidime/avibactam, ceftolozane/tazobactam, cefiderocol, meropenem/vaborbactam, imipenem/relebactam, and aztreonam. Extracorporeal life-support techniques will include continuous renal replacement therapy, conventional intermittent hemodialysis, and extracorporeal membrane oxygenation.The availability of extracorporeal life-support techniques has expanded significantly in recent years, alongside a rise in the prevalence of infections caused by MDR-GNB. There is a need to develop evidence-based tools of high quality to standardize dosing and monitoring strategies for new β-lactam antibiotics.
ISSN:11306343
DOI:10.1016/j.farma.2024.11.005