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Residential exposure to solar ultraviolet radiation and risk of childhood hematological malignancies in Switzerland: A census‐based cohort study

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Bibliographic Details
Title: Residential exposure to solar ultraviolet radiation and risk of childhood hematological malignancies in Switzerland: A census‐based cohort study
Authors: Coste, Astrid, Kreis, Christian, Backes, Claudine, Bulliard, Jean-Luc, Folly, Christophe, Brack, Eva, Renella, Raffaele, Vernez, David, Spycher, Ben
Contributors: SNC study group
Source: Int J Cancer
International journal of cancer, vol. 156, no. 6, pp. 1121-1130
Publisher Information: Wiley, 2024.
Publication Year: 2024
Subject Terms: RESEARCH ARTICLE, sun exposure, ultraviolet radiation, children, cohort study, hematological malignancies, Humans, Switzerland/epidemiology, Child, Child, Preschool, Infant, Male, Female, Adolescent, Ultraviolet Rays/adverse effects, Hematologic Neoplasms/epidemiology, Hematologic Neoplasms/etiology, Infant, Newborn, Environmental Exposure/adverse effects, Risk Factors, Case-Control Studies, Cohort Studies, Sunlight/adverse effects, Censuses, Registries
Description: Still little is known about possible environmental risk factors of childhood hematological malignancies (CHM). Previous studies suggest that ultraviolet radiation (UVR) exposure is associated with a lower risk of acute lymphoblastic leukemia (ALL) in children. We investigated the association between solar UVR exposure and risk of CHM in Switzerland, a country with greatly varying topography and weather conditions. We included all resident children aged 0–15 years from the Swiss National Cohort during 1990–2016 and identified incident cancer cases through probabilistic record linkage with the Swiss Childhood Cancer Registry. We estimated the overall annual mean UV level and the mean level for the month of July during 2004–2018 at children's homes using a climatological model of the midday (11 am–3 pm) UV‐index (UVI) with a spatial resolution of 1.5–2 km. Using risk‐set sampling, we obtained a nested case–control data set matched by birth year and fitted conditional logistic regression models (virtually equivalent to analyzing full cohort data using proportional hazards models) adjusting for sex, neighborhood socio‐economic position, urbanization, air pollution, and background ionizing radiation. Our analyses included 1446 cases of CHM. Estimated adjusted hazard ratios (HR) per unit increase in UVI in July were 0.76 (95% CI 0.59–0.98) for leukemia and 0.74 (0.55–0.98) for ALL. Results for annual exposure were similar but confidence intervals were wider and included one. We found no evidence for an association for lymphoma overall (HR 1.14, 95% CI 0.59–2.19 for annual exposure) or diagnostic subgroups. Our study provides further support for an inverse association between exposure to ambient solar UVR and childhood ALL.
Document Type: Article
Other literature type
File Description: application/pdf
Language: English
ISSN: 1097-0215
0020-7136
DOI: 10.1002/ijc.35214
DOI: 10.48620/76273
Access URL: https://pubmed.ncbi.nlm.nih.gov/39394844
https://serval.unil.ch/notice/serval:BIB_8731CE3456C6
https://serval.unil.ch/resource/serval:BIB_8731CE3456C6.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_8731CE3456C65
Rights: CC BY NC
Accession Number: edsair.doi.dedup.....a218f1b963750aa5deaeb98adbc8423d
Database: OpenAIRE
Description
Abstract:Still little is known about possible environmental risk factors of childhood hematological malignancies (CHM). Previous studies suggest that ultraviolet radiation (UVR) exposure is associated with a lower risk of acute lymphoblastic leukemia (ALL) in children. We investigated the association between solar UVR exposure and risk of CHM in Switzerland, a country with greatly varying topography and weather conditions. We included all resident children aged 0–15 years from the Swiss National Cohort during 1990–2016 and identified incident cancer cases through probabilistic record linkage with the Swiss Childhood Cancer Registry. We estimated the overall annual mean UV level and the mean level for the month of July during 2004–2018 at children's homes using a climatological model of the midday (11 am–3 pm) UV‐index (UVI) with a spatial resolution of 1.5–2 km. Using risk‐set sampling, we obtained a nested case–control data set matched by birth year and fitted conditional logistic regression models (virtually equivalent to analyzing full cohort data using proportional hazards models) adjusting for sex, neighborhood socio‐economic position, urbanization, air pollution, and background ionizing radiation. Our analyses included 1446 cases of CHM. Estimated adjusted hazard ratios (HR) per unit increase in UVI in July were 0.76 (95% CI 0.59–0.98) for leukemia and 0.74 (0.55–0.98) for ALL. Results for annual exposure were similar but confidence intervals were wider and included one. We found no evidence for an association for lymphoma overall (HR 1.14, 95% CI 0.59–2.19 for annual exposure) or diagnostic subgroups. Our study provides further support for an inverse association between exposure to ambient solar UVR and childhood ALL.
ISSN:10970215
00207136
DOI:10.1002/ijc.35214