Zobraziť v EDS

Neurosurgical resection of multiple brain metastases: outcomes, complications, and survival rates in a retrospective analysis

Uložené v:
Podrobná bibliografia
Názov: Neurosurgical resection of multiple brain metastases: outcomes, complications, and survival rates in a retrospective analysis
Autori: Niedermeyer, Sebastian, Schmutzer-Sondergeld, M., Weller, J., Katzendobler, S., Kirchleitner, S., Forbrig, R., Harter, P. N., Baumgarten, L. V., Schichor, C., Stoecklein, V., Thon, N.
Zdroj: J Neurooncol
Informácie o vydavateľovi: Springer Science and Business Media LLC, 2024.
Rok vydania: 2024
Predmety: Male, Brain Neoplasms, Female [MeSH], Follow-Up Studies [MeSH], Brain Neoplasms/secondary [MeSH], Survival rates, Aged [MeSH], Surgical resection, Humans [MeSH], Treatment Outcome [MeSH], Brain Neoplasms/surgery [MeSH], Postoperative Complications/epidemiology [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], Survival Rate [MeSH], Complications, Male [MeSH], Research, Prognosis [MeSH], Brain Neoplasms/mortality [MeSH], Multiple brain metastases, Neurosurgical Procedures/adverse effects [MeSH], Neurosurgical Procedures/mortality [MeSH], Middle Aged, Prognosis, Neurosurgical Procedures, Survival Rate, 03 medical and health sciences, Postoperative Complications, Treatment Outcome, 0302 clinical medicine, Humans, Female, Retrospective Studies, Aged, Follow-Up Studies
Popis: Purpose This study investigates the outcomes of microsurgical resection of multiple brain metastasis (BMs). Methods This retrospective, monocentric analysis included clinical data from all consecutive BM patients, who underwent simultaneous resection of ≥ 2 BMs between January 2018 and May 2023. Postoperative neurological and functional outcomes, along with perioperative complications, as well as survival data were evaluated. Results A total of 47 patients, with a median age of 61 years (IQR 48–69), underwent 73 craniotomies (median 2; range 1–3) for resection of 104 BMs. Among patients, 80.8% presented with symptomatic BMs, causing focal neurological deficits in 53% of cases. Gross total resection was achieved in 87.2% of BMs. Karnofsky Performance Scale (KPS) scores improved in 42.6% of patients, remained unchanged in 46.8%, and worsened in 10.6% after surgery. Perioperative complications were observed in 29.8% of cases, with transient complications occurring in 19.2% and permanent deficits in 10.6%. The 30-days mortality rate was 2.1%. Logistic regression identified eloquent localization (p = 0.036) and infratentorial craniotomy (p = 0.018) as significant predictors of postoperative complications. Concerning overall prognosis, patients with permanent neurological deficits post-surgery (HR 11.34, p = 0.007) or progressive extracranial disease (HR: 4.649; p = 0.006) exhibited inferior survival. Conclusion Microsurgical resection of multiple BMs leads to clinical stabilization or functional improvement in most patients. Although transient complications do not affect overall survival, the presence of persistent neurological deficits (> 3 months post-surgery) and progressive extracranial disease negatively impact overall survival. This highlights the importance of careful patient selection for resection of multiple BMs.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1573-7373
0167-594X
DOI: 10.1007/s11060-024-04744-w
Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38904924
https://repository.publisso.de/resource/frl:6513104
https://epub.ub.uni-muenchen.de/126138/
Rights: CC BY
Prístupové číslo: edsair.doi.dedup.....a0d928ca1b42e1ad0516f8e903413f54
Databáza: OpenAIRE
Popis
Abstrakt:Purpose This study investigates the outcomes of microsurgical resection of multiple brain metastasis (BMs). Methods This retrospective, monocentric analysis included clinical data from all consecutive BM patients, who underwent simultaneous resection of ≥ 2 BMs between January 2018 and May 2023. Postoperative neurological and functional outcomes, along with perioperative complications, as well as survival data were evaluated. Results A total of 47 patients, with a median age of 61 years (IQR 48–69), underwent 73 craniotomies (median 2; range 1–3) for resection of 104 BMs. Among patients, 80.8% presented with symptomatic BMs, causing focal neurological deficits in 53% of cases. Gross total resection was achieved in 87.2% of BMs. Karnofsky Performance Scale (KPS) scores improved in 42.6% of patients, remained unchanged in 46.8%, and worsened in 10.6% after surgery. Perioperative complications were observed in 29.8% of cases, with transient complications occurring in 19.2% and permanent deficits in 10.6%. The 30-days mortality rate was 2.1%. Logistic regression identified eloquent localization (p = 0.036) and infratentorial craniotomy (p = 0.018) as significant predictors of postoperative complications. Concerning overall prognosis, patients with permanent neurological deficits post-surgery (HR 11.34, p = 0.007) or progressive extracranial disease (HR: 4.649; p = 0.006) exhibited inferior survival. Conclusion Microsurgical resection of multiple BMs leads to clinical stabilization or functional improvement in most patients. Although transient complications do not affect overall survival, the presence of persistent neurological deficits (> 3 months post-surgery) and progressive extracranial disease negatively impact overall survival. This highlights the importance of careful patient selection for resection of multiple BMs.
ISSN:15737373
0167594X
DOI:10.1007/s11060-024-04744-w