Determination of the target population in early benefit assessments in Germany: challenges for non-small-cell lung cancer
Uložené v:
| Názov: | Determination of the target population in early benefit assessments in Germany: challenges for non-small-cell lung cancer |
|---|---|
| Autori: | ten Thoren, C., Balg, C., Gibbert, J., Mostardt, S., Ripoll, M., Schierbaum, D., Schiller, S., Schwalm, A. |
| Zdroj: | Eur J Health Econ |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2020. |
| Rok vydania: | 2020 |
| Predmety: | ddc:610, Original Paper, Lung Neoplasms, Technology Assessment, Biomedical, Databases, Factual, Drug Approval/methods [MeSH], New drugs, Humans [MeSH], Early benefit assessment, I18 (Government Policy-Regulation-Public Health), I10 (General), Lung Neoplasms/epidemiology [MeSH], Target population, NSCLC, Databases, Factual [MeSH], Technology Assessment, Biomedical [MeSH], Germany [MeSH], Antineoplastic Agents/therapeutic use [MeSH], Lung Neoplasms/pathology [MeSH], Non-small-cell lung cancer, Carcinoma, Non-Small-Cell Lung/drug therapy [MeSH], Lung Neoplasms/drug therapy [MeSH], Carcinoma, Non-Small-Cell Lung/epidemiology [MeSH], Antineoplastic Agents, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Germany, Humans, Drug Approval |
| Popis: | ObjectivesDossiers submitted for early benefit assessments in Germany also provide information on the precise determination of the target population (patients eligible for a drug). The situation is complex for non-small-cell lung cancer (NSCLC) due to highly specific therapeutic indications. Our aim was to compare the different methodological steps applied to determine the target population in dossiers on drugs for NSCLC.MethodsWe analysed NSCLC dossiers assessed by the German Institute for Quality and Efficiency in Health Care (IQWiG) between 01.01.2011 and 31.12.2017. Methodological details regarding the determination of the target population were extracted and compared.ResultsWe analysed 23 NSCLC dossiers. In all dossiers, the target population was determined using the number of all patients with lung cancer as the basis for calculations. This patient population was further reduced in several successive steps by assuming proportions of patients with a specific characteristic (e.g. disease stage). The most important calculation steps were patients with NSCLC (n = 23 dossiers), with a specific disease stage (n = 23), with a specific tumour mutation (n = 14), with a specific tumour histology (n = 7), without prior treatment (n = 15), with pretreatment in second or further treatment lines (n = 17), and/or with specific pretreatments (n = 9). The proportions of patients determined within the same calculation step varied considerably between dossiers.DiscussionThe calculation methods applied and the target population sizes reported in NSCLC dossiers vary considerably. A consensus with regard to the databases and calculation methods used to determine the target population in NSCLC would be helpful to reduce variations. |
| Druh dokumentu: | Article Other literature type |
| Jazyk: | English |
| ISSN: | 1618-7601 1618-7598 |
| DOI: | 10.1007/s10198-020-01180-1 |
| Prístupová URL adresa: | https://link.springer.com/content/pdf/10.1007/s10198-020-01180-1.pdf https://pubmed.ncbi.nlm.nih.gov/32236766 https://link.springer.com/article/10.1007/s10198-020-01180-1 https://link.springer.com/content/pdf/10.1007/s10198-020-01180-1.pdf https://www.ncbi.nlm.nih.gov/pubmed/32236766 https://hdl.handle.net/10419/288418 https://repository.publisso.de/resource/frl:6470598 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....9f3368cd50db9dea64a27145bbc145d5 |
| Databáza: | OpenAIRE |
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstrakt: | ObjectivesDossiers submitted for early benefit assessments in Germany also provide information on the precise determination of the target population (patients eligible for a drug). The situation is complex for non-small-cell lung cancer (NSCLC) due to highly specific therapeutic indications. Our aim was to compare the different methodological steps applied to determine the target population in dossiers on drugs for NSCLC.MethodsWe analysed NSCLC dossiers assessed by the German Institute for Quality and Efficiency in Health Care (IQWiG) between 01.01.2011 and 31.12.2017. Methodological details regarding the determination of the target population were extracted and compared.ResultsWe analysed 23 NSCLC dossiers. In all dossiers, the target population was determined using the number of all patients with lung cancer as the basis for calculations. This patient population was further reduced in several successive steps by assuming proportions of patients with a specific characteristic (e.g. disease stage). The most important calculation steps were patients with NSCLC (n = 23 dossiers), with a specific disease stage (n = 23), with a specific tumour mutation (n = 14), with a specific tumour histology (n = 7), without prior treatment (n = 15), with pretreatment in second or further treatment lines (n = 17), and/or with specific pretreatments (n = 9). The proportions of patients determined within the same calculation step varied considerably between dossiers.DiscussionThe calculation methods applied and the target population sizes reported in NSCLC dossiers vary considerably. A consensus with regard to the databases and calculation methods used to determine the target population in NSCLC would be helpful to reduce variations. |
|---|---|
| ISSN: | 16187601 16187598 |
| DOI: | 10.1007/s10198-020-01180-1 |