Factors influencing the time to surgery after neoadjuvant chemotherapy in breast cancer patients
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| Názov: | Factors influencing the time to surgery after neoadjuvant chemotherapy in breast cancer patients |
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| Autori: | Carolin Müller, Ingolf Juhasz-Böss, Gilda Schmidt, Peter Jungmann, Erich-Franz Solomayer, Georg-Peter Breitbach, Stephanie Juhasz-Böss |
| Zdroj: | Arch Gynecol Obstet |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2020. |
| Rok vydania: | 2020 |
| Predmety: | Adult, ddc:610, Time Factors, Delaying factors, Breast Neoplasms, Gynecologic Oncology, Middle Aged, Female [MeSH], Aged [MeSH], Adult [MeSH], Humans [MeSH], Breast cancer, Treatment Outcome [MeSH], Breast Neoplasms/drug therapy [MeSH], Middle Aged [MeSH], Time Factors [MeSH], Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MeSH], Neoadjuvant therapy, Young Adult [MeSH], Chemotherapy, Adjuvant/methods [MeSH], Breast Neoplasms/surgery [MeSH], Time to surgery, 3. Good health, Young Adult, 03 medical and health sciences, Treatment Outcome, 0302 clinical medicine, Chemotherapy, Adjuvant, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, 10. No inequality, Aged |
| Popis: | Purpose It is suspected that delayed surgery after neoadjuvant chemotherapy (NACT) leads to a worse outcome in breast cancer patients. We therefore evaluated possible influencing factors of the time interval between the end of NACT and surgery. Methods All patients receiving NACT due to newly diagnosed breast cancer from 2015 to 2017 at the Department of Gynecology, Saarland University Medical Center, were included. The time interval between end of NACT and surgery was defined as primary endpoint. Possible delaying factors were investigated: age, study participation, outpatient and inpatient presentations, implants/expander, MRI preoperatively, discontinuation of chemotherapy, and genetic mutations. Results Data of 139 patients was analyzed. Median age was 53 years (22–78). The time interval between end of NACT and surgery was 28 days (9–57). Additional clinical presentations on outpatient basis added 2 days (p = 0.002) and on inpatient basis added 7 days to time to surgery (p p p = 0.6). In contrast, a proven genetic mutation shortened time to surgery by 7 days (p Conclusion Breast care centers should emphasize a reduction of clinical presentations and a good control of chemotherapy side effects for breast cancer patients to avoid delays of surgery after NACT. |
| Druh dokumentu: | Article Other literature type |
| Jazyk: | English |
| ISSN: | 1432-0711 0932-0067 |
| DOI: | 10.1007/s00404-020-05494-6 |
| DOI: | 10.22028/d291-33806 |
| Prístupová URL adresa: | https://link.springer.com/content/pdf/10.1007/s00404-020-05494-6.pdf https://pubmed.ncbi.nlm.nih.gov/32170410 https://link.springer.com/content/pdf/10.1007/s00404-020-05494-6.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103004 https://www.ncbi.nlm.nih.gov/pubmed/32170410 https://pubmed.ncbi.nlm.nih.gov/32170410/ https://link.springer.com/article/10.1007/s00404-020-05494-6 https://repository.publisso.de/resource/frl:6466638 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....9f0c662be0d59c111087595be6dacc3e |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Purpose It is suspected that delayed surgery after neoadjuvant chemotherapy (NACT) leads to a worse outcome in breast cancer patients. We therefore evaluated possible influencing factors of the time interval between the end of NACT and surgery. Methods All patients receiving NACT due to newly diagnosed breast cancer from 2015 to 2017 at the Department of Gynecology, Saarland University Medical Center, were included. The time interval between end of NACT and surgery was defined as primary endpoint. Possible delaying factors were investigated: age, study participation, outpatient and inpatient presentations, implants/expander, MRI preoperatively, discontinuation of chemotherapy, and genetic mutations. Results Data of 139 patients was analyzed. Median age was 53 years (22–78). The time interval between end of NACT and surgery was 28 days (9–57). Additional clinical presentations on outpatient basis added 2 days (p = 0.002) and on inpatient basis added 7 days to time to surgery (p p p = 0.6). In contrast, a proven genetic mutation shortened time to surgery by 7 days (p Conclusion Breast care centers should emphasize a reduction of clinical presentations and a good control of chemotherapy side effects for breast cancer patients to avoid delays of surgery after NACT. |
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| ISSN: | 14320711 09320067 |
| DOI: | 10.1007/s00404-020-05494-6 |