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Effect of clopidogrel on post extraction clotting in patients on dual antiplatelet therapy

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Název: Effect of clopidogrel on post extraction clotting in patients on dual antiplatelet therapy
Autoři: Zhang, Yaqiong, Zhao, Yijie Zhao, Wang, Meng, Wang, Jiaqi, Yang, Zhicheng, Lu, Mengmeng
Zdroj: Tropical Journal of Pharmaceutical Research; Vol. 22 No. 1 (2023); 189-197
Informace o vydavateli: African Journals Online (AJOL), 2023.
Rok vydání: 2023
Témata: Dual antiplatelet therapy, Clopidogrel responsiveness, Dental extraction, Post-extraction clotting, Thromboelastography platelet mapping assay, Platelet inhibition
Popis: Purpose: To evaluate the association between the platelet inhibition rate of clopidogrel (CLO-PIR) and post-extraction clotting status in DAPT patients. Methods: Ninety (90) eligible patients scheduled for a single tooth extraction were enrolled in this study. The CLO-PIR and platelet inhibition rate of aspirin (ASA-PIR) were determined by thromboelastography platelet mapping assay. Post-extraction clotting assessments were performed, and a complete intra-alveolar clot formation within 30 min post-operation was defined as normal clotting. For clot formation exceeding 30 min, it was defined as prolonged bleeding. Results: At a similar level of ASA-PIR, a higher proportion of patients with normal CLO-PIR (≤ 75 %) exhibited normal clotting, compared with those featuring high CLO-PIR (>75 %, p < 0.001). However, in patients with similar CLO-PIRs, the clotting results varied insignificantly, with increase in ASA-PIR. The effect of CLO-PIR was further validated using logistic regression analysis (odds ratio = 1.071, 95 % confidence interval: 1.024 - 1.120, p = 0.003), and receiver operating characteristic curve analysis revealed that a 78.6 % CLO-PIR was the rational cut-off point. Conclusion: This study preliminarily demonstrates the prominence of high clopidogrel responsiveness in slowing the post-extraction clotting process in DAPT patients.
Druh dokumentu: Article
Popis souboru: application/pdf
ISSN: 1596-9827
1596-5996
DOI: 10.4314/tjpr.v22i1.26
Přístupová URL adresa: https://www.ajol.info/index.php/tjpr/article/view/241858
Přístupové číslo: edsair.doi.dedup.....9e053c10607979dc84d436fbb6d49acd
Databáze: OpenAIRE
Popis
Abstrakt:Purpose: To evaluate the association between the platelet inhibition rate of clopidogrel (CLO-PIR) and post-extraction clotting status in DAPT patients. Methods: Ninety (90) eligible patients scheduled for a single tooth extraction were enrolled in this study. The CLO-PIR and platelet inhibition rate of aspirin (ASA-PIR) were determined by thromboelastography platelet mapping assay. Post-extraction clotting assessments were performed, and a complete intra-alveolar clot formation within 30 min post-operation was defined as normal clotting. For clot formation exceeding 30 min, it was defined as prolonged bleeding. Results: At a similar level of ASA-PIR, a higher proportion of patients with normal CLO-PIR (≤ 75 %) exhibited normal clotting, compared with those featuring high CLO-PIR (>75 %, p < 0.001). However, in patients with similar CLO-PIRs, the clotting results varied insignificantly, with increase in ASA-PIR. The effect of CLO-PIR was further validated using logistic regression analysis (odds ratio = 1.071, 95 % confidence interval: 1.024 - 1.120, p = 0.003), and receiver operating characteristic curve analysis revealed that a 78.6 % CLO-PIR was the rational cut-off point. Conclusion: This study preliminarily demonstrates the prominence of high clopidogrel responsiveness in slowing the post-extraction clotting process in DAPT patients.
ISSN:15969827
15965996
DOI:10.4314/tjpr.v22i1.26