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Neuromodulation and Mindfulness as Therapeutic Treatment in Detoxified Patients with Alcohol Use Disorder

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Title: Neuromodulation and Mindfulness as Therapeutic Treatment in Detoxified Patients with Alcohol Use Disorder
Authors: Rosenthal, Annika, Haslacher, D., Garbusow, M., Pangratz, L., Apfel, B., Soekadar, S., Romanczuk-Seiferth, N., Beck, A.
Source: BMC Psychiatry
BMC Psychiatry, Vol 24, Iss 1, Pp 1-9 (2024)
Publisher Information: Springer Science and Business Media LLC, 2024.
Publication Year: 2024
Subject Terms: Adult, Male, Vagus Nerve Stimulation, RC435-571, Transcranial Direct Current Stimulation, Alcohol use disorder, Study Protocol, Cue reactivity, Frontal midline theta, Secondary Prevention, Humans, Theta Rhythm, Craving, Randomized Controlled Trials as Topic, Interception, Psychiatry, Middle Aged, Combined Modality Therapy, Alcoholism, Mindfulness-based relapse prevention, Cognitive control, Alcoholism/therapy [MeSH], Transcutaneous Electric Nerve Stimulation/methods [MeSH], Mindfulness/methods [MeSH], Transcranial Direct Current Stimulation/methods [MeSH], Vagus Nerve Stimulation/methods [MeSH], Alcoholism/physiopathology [MeSH], Randomized Controlled Trials as Topic [MeSH], Electroencephalography, Male [MeSH], Vagus nerve stimulation, Combined Modality Therapy [MeSH], Closed-loop amplitude-modulated transcranial alternating current stimulation, Female [MeSH], Adult [MeSH], Humans [MeSH], Craving/physiology [MeSH], Middle Aged [MeSH], Theta Rhythm/physiology [MeSH], Neuromodulation, Heart rate variability, Cues [MeSH], Secondary Prevention [MeSH], Transcutaneous Electric Nerve Stimulation, Female, Cues, Mindfulness
Description: Background Alcohol use disorder (AUD) poses a significant global health challenge. Traditional management strategies often face high relapse rates, leading to a need for innovative approaches. Mindfulness-based relapse prevention (MBRP) has emerged as a promising intervention to enhance cognitive control, reduce cue-related craving and improve interoceptive processing. Neuroimaging studies suggest that mindfulness training can modulate brain networks associated with these factors, potentially improving treatment outcomes for AUD. Neuroimaging studies suggest that mindfulness training can modulate brain networks linked to these brain functions, potentially improving treatment outcomes for AUD. However, it is unclear how MBRP links to neurophysiological measures such as frontal midline theta oscillations (FMΘ) and whether the beneficial effects of MBRP can be increased by enhancing FMΘ. Here, we will use two different forms of neuromodulation to target and enhance these oscillations, and evaluate their impact on the effectiveness of MBRP. Methods This study will employ a four-arm randomized controlled trial to evaluate the synergistic effects of MBRP augmented with transcutaneous vagus nerve stimulation (tVNS) or closed-loop amplitude-modulated transcranial alternating current stimulation (CLAM-tACS) on cognitive control, cue reactivity and interoceptive processing in AUD patients. Participants will undergo six weekly group MBRP sessions and daily individual mindfulness practices. Assessments will include an inhibition task, cue-induced craving task, and heartbeat discrimination task, alongside heart rate variability and 32-channel EEG recordings. Participants will be assessed pre and post treatment, with a three-month follow-up to evaluate long-term effects on abstinence and alcohol consumption. Discussion This study will not only elucidate the causal link between FMΘ and efficacy of MBRP, but contribute to a better understanding of how combined psychological and neuromodulation interventions can improve treatment outcomes for AUD, potentially leading to more effective therapeutic strategies. This study also seeks to explore individual differences in response to treatment, which could inform future approaches to AUD management. Trial registration This study received approval by the Charité—Universitätsmedizin Berlin Institutional Review Board (EA1/030/23, 10.11.2023). It was registered on ClinicalTrials.gov (NCT06308484).
Document Type: Article
Other literature type
ISSN: 1471-244X
DOI: 10.21203/rs.3.rs-4564491/v1
DOI: 10.1186/s12888-024-06085-4
Access URL: https://pubmed.ncbi.nlm.nih.gov/39334026
https://doaj.org/article/2eca891bfd8747a9b742f2f9ab1e49f8
https://repository.publisso.de/resource/frl:6497663
Rights: CC BY
Accession Number: edsair.doi.dedup.....9ddd352c5965d3619ddbace247298b39
Database: OpenAIRE
Description
Abstract:Background Alcohol use disorder (AUD) poses a significant global health challenge. Traditional management strategies often face high relapse rates, leading to a need for innovative approaches. Mindfulness-based relapse prevention (MBRP) has emerged as a promising intervention to enhance cognitive control, reduce cue-related craving and improve interoceptive processing. Neuroimaging studies suggest that mindfulness training can modulate brain networks associated with these factors, potentially improving treatment outcomes for AUD. Neuroimaging studies suggest that mindfulness training can modulate brain networks linked to these brain functions, potentially improving treatment outcomes for AUD. However, it is unclear how MBRP links to neurophysiological measures such as frontal midline theta oscillations (FMΘ) and whether the beneficial effects of MBRP can be increased by enhancing FMΘ. Here, we will use two different forms of neuromodulation to target and enhance these oscillations, and evaluate their impact on the effectiveness of MBRP. Methods This study will employ a four-arm randomized controlled trial to evaluate the synergistic effects of MBRP augmented with transcutaneous vagus nerve stimulation (tVNS) or closed-loop amplitude-modulated transcranial alternating current stimulation (CLAM-tACS) on cognitive control, cue reactivity and interoceptive processing in AUD patients. Participants will undergo six weekly group MBRP sessions and daily individual mindfulness practices. Assessments will include an inhibition task, cue-induced craving task, and heartbeat discrimination task, alongside heart rate variability and 32-channel EEG recordings. Participants will be assessed pre and post treatment, with a three-month follow-up to evaluate long-term effects on abstinence and alcohol consumption. Discussion This study will not only elucidate the causal link between FMΘ and efficacy of MBRP, but contribute to a better understanding of how combined psychological and neuromodulation interventions can improve treatment outcomes for AUD, potentially leading to more effective therapeutic strategies. This study also seeks to explore individual differences in response to treatment, which could inform future approaches to AUD management. Trial registration This study received approval by the Charité—Universitätsmedizin Berlin Institutional Review Board (EA1/030/23, 10.11.2023). It was registered on ClinicalTrials.gov (NCT06308484).
ISSN:1471244X
DOI:10.21203/rs.3.rs-4564491/v1