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Safety, efficacy, gastrointestinal tolerance, and digestibility of brewed chicken protein in healthy adult dogs

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Titel: Safety, efficacy, gastrointestinal tolerance, and digestibility of brewed chicken protein in healthy adult dogs
Autoren: Meredith A. Smola, Patrícia M. Oba, Julio C. Mioto, Pernilla Audibert, Tomas Belloso, Kelly S. Swanson
Quelle: Front Vet Sci
Frontiers in Veterinary Science, Vol 12 (2025)
Verlagsinformationen: Frontiers Media SA, 2025.
Publikationsjahr: 2025
Schlagwörter: canine nutrition, Veterinary medicine, SF600-1100, pet food, precision fermentation, novel protein, Veterinary Science, sustainability
Beschreibung: IntroductionProducing enough protein continues to be a challenge, but alternatives may provide economic and ecological relief. Sufficient testing is necessary to confirm safety and evaluate nutritional value. Our objective was to evaluate the safety, efficacy, gastrointestinal tolerance, and apparent total tract digestibility (ATTD) of brewed chicken protein (BCP; Saccharomyces cerevisiae expressing a chicken protein).MethodsThirty-two healthy adult dogs (BW = 9.68 ± 1.18 kg; age = 4.16 ± 1.85 yr) were used in a completely randomized design (n = 8/treatment). After a 2-wk acclimation phase, baseline measurements were collected and dogs were allotted to the following treatments and fed for 26 wk: control diet (0% BCP; Control), 15% BCP (Low), 30% BCP (Medium), or 40% BCP (High). Palatability was assessed by comparing dry diets coated with 0% (control) vs. 1% BCP in 20 adult dogs. Data were analyzed using the Mixed Models procedure of SAS 9.4, with p p ResultsConsumption of BCP did not affect food intake, BW, physical parameters, serum chemistry, hematology, and urinalysis. The dry matter, organic matter, and crude protein ATTD were greater (p p p p p p = 0.06) in dogs fed BCP. Fecal isobutyrate, isovalerate, indole, total phenol and indole, and ammonia concentrations were lower (p p p p ConclusionThese results indicate that the BCP ingredient tested is an effective source of protein that is safe for use in adult dog foods at an inclusion level of up to 40%. No detrimental effects were observed, and notable changes to nutrient digestibility and fecal characteristics, metabolites, and microbiota populations suggest potential benefits on gastrointestinal health.
Publikationsart: Article
Other literature type
ISSN: 2297-1769
DOI: 10.3389/fvets.2025.1593209
Zugangs-URL: https://doaj.org/article/b5861efc71434c5ebfd5465b6a03b86e
Rights: CC BY
Dokumentencode: edsair.doi.dedup.....9d4e8397a014ccf7602e94cea8abf35f
Datenbank: OpenAIRE
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Beschreibung
Abstract:IntroductionProducing enough protein continues to be a challenge, but alternatives may provide economic and ecological relief. Sufficient testing is necessary to confirm safety and evaluate nutritional value. Our objective was to evaluate the safety, efficacy, gastrointestinal tolerance, and apparent total tract digestibility (ATTD) of brewed chicken protein (BCP; Saccharomyces cerevisiae expressing a chicken protein).MethodsThirty-two healthy adult dogs (BW = 9.68 ± 1.18 kg; age = 4.16 ± 1.85 yr) were used in a completely randomized design (n = 8/treatment). After a 2-wk acclimation phase, baseline measurements were collected and dogs were allotted to the following treatments and fed for 26 wk: control diet (0% BCP; Control), 15% BCP (Low), 30% BCP (Medium), or 40% BCP (High). Palatability was assessed by comparing dry diets coated with 0% (control) vs. 1% BCP in 20 adult dogs. Data were analyzed using the Mixed Models procedure of SAS 9.4, with p p ResultsConsumption of BCP did not affect food intake, BW, physical parameters, serum chemistry, hematology, and urinalysis. The dry matter, organic matter, and crude protein ATTD were greater (p p p p p p = 0.06) in dogs fed BCP. Fecal isobutyrate, isovalerate, indole, total phenol and indole, and ammonia concentrations were lower (p p p p ConclusionThese results indicate that the BCP ingredient tested is an effective source of protein that is safe for use in adult dog foods at an inclusion level of up to 40%. No detrimental effects were observed, and notable changes to nutrient digestibility and fecal characteristics, metabolites, and microbiota populations suggest potential benefits on gastrointestinal health.
ISSN:22971769
DOI:10.3389/fvets.2025.1593209