The impact of naturally-occurring, trans-placental bluetongue virus serotype-8 infection on reproductive performance in sheep
Uložené v:
| Názov: | The impact of naturally-occurring, trans-placental bluetongue virus serotype-8 infection on reproductive performance in sheep |
|---|---|
| Autori: | Saegerman, Claude, Bolkaerts, Benoit, Baricalla, Christine, Raes, Marianne, Wiggers, Laetitia, de Leeuw, Ilse, Vandenbussche, Frank, Zimmer, Jean-Yves, Haubruge, Eric, Cassart, Dominique, De Clercq, Kris, Kirschvink, Nathalie |
| Zdroj: | The Veterinary Journal. 187:72-80 |
| Informácie o vydavateľovi: | Elsevier BV, 2011. |
| Rok vydania: | 2011 |
| Predmety: | 0301 basic medicine, Pregnancy Complications, Infectious/veterinary, Placenta/virology, Placenta, Bluetongue, Disease Outbreaks, 0403 veterinary science, Abortion, Veterinary/epidemiology/virology, Veterinary medicine & animal health, 03 medical and health sciences, Belgium, Bluetongue/epidemiology/transmission, Bluetongue serotype-8, Pregnancy, Infectious Disease Transmission, Vertical/veterinary, Animals, Pregnancy Complications, Infectious, Serotyping, Belgium/epidemiology, 2. Zero hunger, Sheep, Over-wintering, Disease Outbreaks/veterinary, Serotyping/veterinary, Abortion, Trans-placental infection, Emerging infectious disease, 04 agricultural and veterinary sciences, Abortion, Veterinary, Life sciences, Médecine vétérinaire & santé animale, Infectious Disease Transmission, Vertical, 3. Good health, Bluetongue virus/isolation & purification, Sciences du vivant, Female, Bluetongue virus |
| Popis: | Infection with bluetongue virus serotype (BTV)-8 occurred in ruminants in 2006 in Central-Western Europe. The trans-placental passage of this virus has been demonstrated in naturally- and experimentally-infected cattle and in experimentally-infected sheep. Trans-placental transmission is potentially important in the 'over-wintering' of this virus and its subsequent impact on reproductive performance. This epidemiological study was carried out on a sheep flock in Belgium that had experienced a severe outbreak of BTV-8 infection, and where the seroprevalence had increased from 1.3% to 88% between January and November 2007. In total, 476 lambs and 26 aborted fetuses from 300 ewes, lambing at four distinct time periods, were investigated between November 2007 and May 2008. The following evidence suggested that BTV-8 infection occurred in utero: (1) positive PCR results from splenic tissue from aborted fetuses (n=4); (2) fetal malformations suggestive of BTV infection (n=10); (3) positive PCR results from red blood cells in-lambs (n=7), and (4) the presence of antibody at birth in viable lambs prior to the intake of colostrum (n=9). The evidence provided by this investigation strongly suggests that trans-placental BTV-8 infection occurs in naturally-infected sheep and the impact of infection on the reproductive performance of such a naïve flock was considerable, with up to 25% of ewes aborting and with flock fertility reduced by 50%. The contribution of in utero-infected lambs to the over-wintering of BTV appears limited. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1090-0233 |
| DOI: | 10.1016/j.tvjl.2009.11.012 |
| Prístupová URL adresa: | https://orbi.uliege.be/bitstream/2268/63957/1/2010-The%20impact%20of%20naturally-occuring%20transplacental%20bluetongue%20virus.pdf https://pubmed.ncbi.nlm.nih.gov/20061168 https://researchportal.unamur.be/en/publications/5f4d4653-cbcf-43ef-9798-cec6551ffc64 https://doi.org/10.1016/j.tvjl.2009.11.012 https://www.ncbi.nlm.nih.gov/pubmed/20061168 https://pubmed.ncbi.nlm.nih.gov/20061168/ http://www.sciencedirect.com/science/article/pii/S109002330900450X http://orbi.ulg.ac.be/bitstream/2268/63957/1/2010-The%20impact%20of%20naturally-occuring%20transplacental%20bluetongue%20virus.pdf https://core.ac.uk/display/13325758 https://www.sciencedirect.com/science/article/pii/S109002330900450X https://hdl.handle.net/2268/63957 https://doi.org/10.1016/j.tvjl.2009.11.012 |
| Rights: | Elsevier TDM |
| Prístupové číslo: | edsair.doi.dedup.....9c351d91725344c8f54d7aa06520459d |
| Databáza: | OpenAIRE |
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstrakt: | Infection with bluetongue virus serotype (BTV)-8 occurred in ruminants in 2006 in Central-Western Europe. The trans-placental passage of this virus has been demonstrated in naturally- and experimentally-infected cattle and in experimentally-infected sheep. Trans-placental transmission is potentially important in the 'over-wintering' of this virus and its subsequent impact on reproductive performance. This epidemiological study was carried out on a sheep flock in Belgium that had experienced a severe outbreak of BTV-8 infection, and where the seroprevalence had increased from 1.3% to 88% between January and November 2007. In total, 476 lambs and 26 aborted fetuses from 300 ewes, lambing at four distinct time periods, were investigated between November 2007 and May 2008. The following evidence suggested that BTV-8 infection occurred in utero: (1) positive PCR results from splenic tissue from aborted fetuses (n=4); (2) fetal malformations suggestive of BTV infection (n=10); (3) positive PCR results from red blood cells in-lambs (n=7), and (4) the presence of antibody at birth in viable lambs prior to the intake of colostrum (n=9). The evidence provided by this investigation strongly suggests that trans-placental BTV-8 infection occurs in naturally-infected sheep and the impact of infection on the reproductive performance of such a naïve flock was considerable, with up to 25% of ewes aborting and with flock fertility reduced by 50%. The contribution of in utero-infected lambs to the over-wintering of BTV appears limited. |
|---|---|
| ISSN: | 10900233 |
| DOI: | 10.1016/j.tvjl.2009.11.012 |