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Variation and transmission of the human gut microbiota across multiple familial generations

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Název: Variation and transmission of the human gut microbiota across multiple familial generations
Autoři: Mireia Valles-Colomer, Rodrigo Bacigalupe, Sara Vieira-Silva, Shinya Suzuki, Youssef Darzi, Raul Y. Tito, Takuji Yamada, Nicola Segata, Jeroen Raes, Gwen Falony
Přispěvatelé: UCL - SSS/IREC - Institut de recherche expérimentale et clinique
Zdroj: Nat Microbiol
Nat Microbiol, Vol. 7, no.1, p. 87-96 (2022)
Informace o vydavateli: Springer Science and Business Media LLC, 2021.
Rok vydání: 2021
Témata: Adult, 0301 basic medicine, Adolescent, DIVERSITY, CHILDREN, Bacterial Physiological Phenomena, Microbiology, Article, Preschool Cohort Studies *Family Feces/microbiology Female Gastrointestinal Microbiome/*genetics/physiology Humans *Metagenome Metagenomics/methods Middle Aged RNA, LIKELIHOOD, Cohort Studies, Feces, Young Adult, 03 medical and health sciences, RICHNESS, 1108 Medical Microbiology, RNA, Ribosomal, 16S, REGRESSION, Humans, Family, R PACKAGE, Child, LEVEL ANALYSIS, Aged, 80 and over Bacteria/classification/*genetics Bacterial Physiological Phenomena/genetics Child Child, Ribosomal, RISK, Aged, 80 and over, Science & Technology, Bacteria, 16S/genetics Young Adult, Child, Preschool, Female, Gastrointestinal Microbiome, Metagenomics, Middle Aged, Metagenome, CATALOG, BODY-MASS INDEX, 3107 Microbiology, Adolescent Adult Aged Aged, Life Sciences & Biomedicine, 0605 Microbiology
Popis: Although the composition and functional potential of the human gut microbiota evolve over the lifespan, kinship has been identified as a key covariate of microbial community diversification. However, to date, sharing of microbiota features within families has mostly been assessed between parents and their direct offspring. Here we investigate the potential transmission and persistence of familial microbiome patterns and microbial genotypes in a family cohort (n = 102) spanning 3 to 5 generations over the same female bloodline. We observe microbiome community composition associated with kinship, with seven low abundant genera displaying familial distribution patterns. While kinship and current cohabitation emerge as closely entangled variables, our explorative analyses of microbial genotype distribution and transmission estimates point at the latter as a key covariate of strain dissemination. Highest potential transmission rates are estimated between sisters and mother–daughter pairs, decreasing with increasing daughter’s age and being higher among cohabiting pairs than those living apart. Although rare, we detect potential transmission events spanning three and four generations, primarily involving species of the generaAlistipesandBacteroides. Overall, while our analyses confirm the existence of family-bound microbiome community profiles, transmission or co-acquisition of bacterial strains appears to be strongly linked to cohabitation.
Druh dokumentu: Article
Other literature type
Popis souboru: application/pdf
Jazyk: English
ISSN: 2058-5276
DOI: 10.1038/s41564-021-01021-8
Přístupová URL adresa: https://www.nature.com/articles/s41564-021-01021-8.pdf
https://pubmed.ncbi.nlm.nih.gov/34969979
https://hdl.handle.net/2078.1/305299
https://hdl.handle.net/11572/355074
https://doi.org/10.1038/s41564-021-01021-8
https://www.nature.com/articles/s41564-021-01021-8#rightslink
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) .
Přístupové číslo: edsair.doi.dedup.....9c102a2f6282875acbe86d0f4b1874b7
Databáze: OpenAIRE
Popis
Abstrakt:Although the composition and functional potential of the human gut microbiota evolve over the lifespan, kinship has been identified as a key covariate of microbial community diversification. However, to date, sharing of microbiota features within families has mostly been assessed between parents and their direct offspring. Here we investigate the potential transmission and persistence of familial microbiome patterns and microbial genotypes in a family cohort (n = 102) spanning 3 to 5 generations over the same female bloodline. We observe microbiome community composition associated with kinship, with seven low abundant genera displaying familial distribution patterns. While kinship and current cohabitation emerge as closely entangled variables, our explorative analyses of microbial genotype distribution and transmission estimates point at the latter as a key covariate of strain dissemination. Highest potential transmission rates are estimated between sisters and mother–daughter pairs, decreasing with increasing daughter’s age and being higher among cohabiting pairs than those living apart. Although rare, we detect potential transmission events spanning three and four generations, primarily involving species of the generaAlistipesandBacteroides. Overall, while our analyses confirm the existence of family-bound microbiome community profiles, transmission or co-acquisition of bacterial strains appears to be strongly linked to cohabitation.
ISSN:20585276
DOI:10.1038/s41564-021-01021-8