Atomic-level mechanisms of abnormal activation in NRAS oncogenes from two-dimensional free energy landscapes
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| Názov: | Atomic-level mechanisms of abnormal activation in NRAS oncogenes from two-dimensional free energy landscapes |
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| Autori: | Zheyao Hu, Jordi Martí |
| Prispievatelia: | Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. CCQM - Condensed, Complex and Quantum Matter Group |
| Zdroj: | UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) |
| Informácie o vydavateľovi: | Royal Society of Chemistry (RSC), 2025. |
| Rok vydania: | 2025 |
| Predmety: | Oncogens, Àrees temàtiques de la UPC::Ciències de la salut, Àrees temàtiques de la UPC::Enginyeria química, Membrane Proteins, Oncogenes, 02 engineering and technology, Molecular Dynamics Simulation, 01 natural sciences, GTP Phosphohydrolases, 0104 chemical sciences, NRAS oncogenes, Mutation, Humans, Thermodynamics, 0210 nano-technology, Melanoma, well-tempered metadynamics, free energy surfaces |
| Popis: | The NRAS-mutant subset of melanoma is one of the most aggressive and lethal types associated with poor overall survival. |
| Druh dokumentu: | Article |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 2040-3372 2040-3364 |
| DOI: | 10.1039/d4nr03372h |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/39775302 https://hdl.handle.net/2117/425634 https://doi.org/10.1039/d4nr03372h |
| Rights: | CC BY NC |
| Prístupové číslo: | edsair.doi.dedup.....99d0b42feb36ad95f888a6718f2b1eb4 |
| Databáza: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | The NRAS-mutant subset of melanoma is one of the most aggressive and lethal types associated with poor overall survival. |
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| ISSN: | 20403372 20403364 |
| DOI: | 10.1039/d4nr03372h |