Combined portal and hepatic vein embolisation in perihilar cholangiocarcinoma
Uložené v:
| Názov: | Combined portal and hepatic vein embolisation in perihilar cholangiocarcinoma |
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| Autori: | Smits, Jens, Chau, Steven, James, Sinéad, Korenblik, Remon, Tschögl, Madita, Arntz, Pieter, Bednarsch, Jan, Abreu de Carvalho, Luis, Detry, Olivier, Erdmann, Joris, Gruenberger, Thomas, Hermie, Laurens, Neumann, Ulf, Sandström, Per, Sutcliffe, Robert, Denys, Alban, Melloul, Emmanuel, Dewulf, Maxime, van der Leij, Christiaan, van Dam, Ronald M., Chevallier, Patrick, Wigmore, Stephen, Newhook, Timothy, Vauthey, Jean-Nicolas, Memeo, Riccardo, Dasari, Bobby VM., Braunwarth, Eva, Aldrighetti, Luca, Andorrà, Esteban Cugat, Arslan, Bulent, van Baardewijk, Laurens, Baclija, Ivan, Ball, Chad, Barbier, Louise, Bemelmans, Marc, Bent, Clare, van den Bergh, Frans, Billingsley, Kevin, Binkert, Christoph, Björnsson, Bergthor, de Boer, Marieke T., Bokkers, Reinoud P. H., de Boo, Diederick, Garcia Borobia, Francisco Javier, Braat, Dries, Breen, David, Breitenstein, Stefan, Brousseau, Karine, Bruijnen, Ruther, Bruners, Philipp, Bruns, Christiane, Bunck, Alexander, Burgmans, Mark, Cappelli, Alberta, Carling, Ulrik, de Carvalho, Luis Abreu, Cha, Charles, Chan, Benjamin, Chand, Belinda, Chapelle, Thiery, De Cobelli, Franceso, Coubeau, Laurent, Criado, Eva, Croagh, Daniel, D'Hondt, Mathieu, van Dam, Ronald, Damink, Steven Olde, Davis, Rob, Delle, Martin, Deprez, Fabrice, Dili, Alexandra, Dixon, Matthew, Díaz-Nieto, Rafael, Erdmann, Joris I., Fernando, Rukshan, Font, Jaume Codina, Fouraschen, Suomi, François, Olivier, Fretland, Åsmund A., Fundora, Yilian, Gadani, Sameer, Gallinger, Steven, Geleabert, Alexandra, Gerard, Laurent, Giménez, Josep Guitart, Gobardhan, Paul, Goffette, Pierre, Grochola, Lukasz Filip, Grünhagen, Dirk, Guiliante, Felice, Gómez, Fernando, Hagendoorn, Jeroen, Hammond, John, Heijmans, Margot, Heil, Jan, Heise, Daniel, Laurens Hermie, null, Herrero, Eric, Hess, Gebriel, Heye, Sam, Hoffmann, Martin, Iezzi, Roberto, Imani, Farshad, James, Sinead, Jardinet, Thomas, Joshi, Kunal, Jovine, Elio, Kalil, Jennifer, Karanicolas, Paul, Kazemier, Geert, Kern, Lars, Kingham, Peter, Klass, Darren, Koerkamp, Bas Groot, Kollmar, Otto, Choon Kwon, null, Céline Lambrecht, null, Sven Lang, null, Laura-Ann, null, Leclercq, Wouter, Lindsay, Richard, Lopez-Ben, Santiago, Lucidi, Valerio, López, Jordi Navinés, Macdonald, Andrew, Madoff, David C., Markose, George, Maroune, Gilbert, Martel, Guillaume, Martin, Ernesto Santos, Mehrzad, Homoyon, Meijerink, Martijn, Messaoudi, Nouredin, Metrakos, Peter, Modi, Sachin, Montanari, Nicola, Moragues, Jaume Sampere, Mujoomdar, Amol, Oor, Jelmer, Pappas, Patroklos, Pieterman, Kay, Primrose, John, Qu, Xudong, Ratti, Francesca, Ridouani, Fourat, Borel Rinkes, Inne H. M., Casellas i Robert, Margarida, Ross, Steffen, Ruo, Leyo, Ryan, Stephen, Salik, Aysun, Santol, Jonas, Sarría, Luis, Schaarschmidt, Benedikt, Schadde, Erik, Schiesser, Marc, Schmelzle, Moritz, Seeger, Nico, Segedi, Maja, Serenari, Matteo, Gregory Sergeant, null, Serrablo, Alejandro, Simon, Sorina, Skaro, Anton, Smits, Maarten, Snitzbauer, Andreas, Soonawalla, Zahir, Sparrelid, Ernesto, Spuentrup, Elmar, Stavrou, Gregor, Swijnenburg, Rutger-Jan, Tancredi, Ilario, Tasse, Jordan C., Udupa, Venkatesha, Valenti, David A., Vass, David, van der Velden, Ariadne Lisa, Vogl, Thomas, Wacker, Frank, Wang, Xiaoying, Weitz, Jürgen, White, Steven, Widyaningsih, Rizky, De Wispelaere, Jean-François, Zijlstra, Ijsbrand |
| Prispievatelia: | UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de chirurgie, UCL - (MGD) Service de radiologie - résonance magnétique, EuroLVD and DRAGON Trials Collaborative, Chevallier, P., Wigmore, S., Newhook, T., Vauthey, J.N., Memeo, R., Dasari, B.V., Braunwarth, E., Aldrighetti, L., Andorrà, E.C., Arntz, P., Arslan, B., van Baardewijk, L., Baclija, I., Ball, C., Barbier, L., Bednarsch, J., Bemelmans, M., Bent, C., van den Bergh, F., Billingsley, K., Binkert, C., Björnsson, B., de Boer, M.T., Bokkers, RPH, de Boo, D., Garcia Borobia, F.J., Braat, D., Breen, D., Breitenstein, S., Brousseau, K., Bruijnen, R., Bruners, P., Bruns, C., Bunck, A., Burgmans, M., Cappelli, A., Carling, U., de Carvalho, L.A., Cha, C., Chan, B., Chand, B., Chapelle, T., De Cobelli, F., Coubeau, L., Criado, E., Croagh, D., D'Hondt, M., van Dam, R., Damink, S.O., Davis, R., Delle, M., Denys, A., Deprez, F., Detry, O., Dewulf, M., Dili, A., Dixon, M., Díaz-Nieto, R., Erdmann, J.I., Fernando, R., Font, J.C., Fouraschen, S., François, O., Fretland, Å.A., Fundora, Y., Gadani, S., Gallinger, S., Geleabert, A., Gerard, L., Giménez, J.G., Gobardhan, P., Goffette, P., Grochola, L.F., Gruenberger, T., Grünhagen, D., Guiliante, F., Gómez, F., Hagendoorn, J., Hammond, J., Heijmans, M., Heil, J., Heise, D., Hermie, L., Herrero, E., Hess, G., Heye, S., Hoffmann, M., Iezzi, R., Imani, F., James, S., Jardinet, T., Joshi, K., Jovine, E., Kalil, J., Karanicolas, P., Kazemier, G., Kern, L., Kingham, P., Klass, D., Koerkamp, B.G., Kollmar, O., Korenblik, R., Kwon, C., Lambrecht, C., Lang, S., X., LA, Leclercq, W., van der Leij, C., Lindsay, R., Lopez-Ben, S., Lucidi, V., López, J.N., Macdonald, A., Madoff, D.C., Markose, G., Maroune, G., Martel, G., Martin, E.S., Mehrzad, H., Meijerink, M., Melloul, E., Messaoudi, N., Metrakos, P., Modi, S., Montanari, N., Moragues, J.S., Mujoomdar, A., Neumann, U., Oor, J., Pappas, P., Pieterman, K., Primrose, J., Qu, X., Ratti, F., Ridouani, F., Borel Rinkes, IHM, Casellas I Robert, M., Ross, S., Ruo, L., Ryan, S., Salik, A., Sandström, P., Santol, J., Sarría, L., Schaarschmidt, B., Schadde, E., Schiesser, M., Schmelzle, M., Seeger, N., Segedi, M., Serenari, M., Sergeant, G., Serrablo, A., Simon, S., Skaro, A., Smits, M., Smits, J., Snitzbauer, A., Soonawalla, Z., Sparrelid, E., Spuentrup, E., Stavrou, G., Sutcliffe, R., Swijnenburg, R.J., Tancredi, I., Tasse, J.C., Tschögl, M., Udupa, V., Valenti, D.A., Vass, D., van der Velden, A.L., Vogl, T., Wacker, F., Wang, X., Weitz, J., White, S., Widyaningsih, R., De Wispelaere, J.F., Zijlstra, I., Lang, Sven (Beitragende*r), Schaarschmidt, Benedikt (Beitragende*r) |
| Zdroj: | HPB : the official journal of the International Hepato Pancreato Biliary Association, Vol. 26, no. 12, p. 1458-1466 (2024) HPB, vol. 26, no. 12, pp. 1458-1466 HPB |
| Informácie o vydavateľovi: | Elsevier BV, 2024. |
| Rok vydania: | 2024 |
| Predmety: | Male, RESECTION, Time Factors, Medizin, EXTENDED HEPATECTOMY, LIVER VENOUS DEPRIVATION, complication, carcinoma, Hepatic Veins, liver, Sciences de la santé humaine, surgery, Postoperative Complications, Medicine and Health Sciences, FAILURE, cancer, Humans, Hepatectomy, BILIARY CANCER, Human health sciences, Portal and hepatic vein embolisation, perihilar cholangiocarcinoma, liver surgery, Chirurgie, Retrospective Studies, Aged, OUTCOMES, Portal Vein, MORTALITY, Biology and Life Sciences, Gastroentérologie & hépatologie, Middle Aged, PREOPERATIVE CHOLANGITIS, Embolization, Therapeutic, 3. Good health, Treatment Outcome, Bile Duct Neoplasms, VOLUME, klastkin, Surgery, Female, REMNANT, Bile Duct Neoplasms/surgery, Bile Duct Neoplasms/mortality, Bile Duct Neoplasms/therapy, Bile Duct Neoplasms/pathology, Klatskin Tumor/surgery, Klatskin Tumor/therapy, Klatskin Tumor/mortality, Embolization, Therapeutic/adverse effects, Portal Vein/surgery, Postoperative Complications/etiology, Liver Failure/etiology, Gastroenterology & hepatology, Liver Failure, transplantation, Klatskin Tumor |
| Popis: | Major hepatectomy in perihilar cholangiocarcinoma (pCCA) patients with a small future liver remnant (FLR) risks posthepatectomy liver failure (PHLF). This study examines combined portal and hepatic vein embolisation (PVE/HVE) to increase preoperative FLR volume and potentially decrease PHLF rates.In this retrospective, multicentre, observational study, data was collected from centres affiliated with the DRAGON Trials Collaborative and the EuroLVD registry. The study included pCCA patients who underwent PVE/HVE between July 2016 and January 2023.Following PVE/HVE, 28% of patients (9/32) experienced complications, with 22% (7/32) necessitating biliary interventions for cholangitis. The median degree of hypertrophy after a median of 16 days was 16% with a kinetic growth rate of 6.8% per week. 69% of patients (22/32) ultimately underwent surgical resection. Cholangitis after PVE/HVE was associated with unresectability. After resection, 55% of patients (12/22) experienced complications, of which 23% (5/22) were Clavien-Dindo grade III or higher. The 90-day mortality after resection was 0%.PVE/HVE quickly enhances the kinetic growth rate in pCCA patients. Cholangitis impairs chances on resection significantly. Resection after PVE/HVE is associated with low levels of 90-day mortality. The study highlights the potential of PVE/HVE in improving safety and outcomes in pCCA undergoing resection. |
| Druh dokumentu: | Article |
| Popis súboru: | application/pdf; application/zip; text |
| Jazyk: | English |
| ISSN: | 1365-182X |
| DOI: | 10.1016/j.hpb.2024.07.407 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/39277435 https://hdl.handle.net/2078.1/291848 https://serval.unil.ch/notice/serval:BIB_38452DFE18C9 http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_38452DFE18C91 https://serval.unil.ch/resource/serval:BIB_38452DFE18C9.P001/REF.pdf https://biblio.ugent.be/publication/01JSGWCY5RFF765DRF1BKT4XYP/file/01JSGWDDMJPSMMEV221KDPY2Y0 http://hdl.handle.net/1854/LU-01JSGWCY5RFF765DRF1BKT4XYP https://biblio.ugent.be/publication/01JSGWCY5RFF765DRF1BKT4XYP http://doi.org/10.1016/j.hpb.2024.07.407 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....97d074e1f5dd80cc3d76fde6929323c1 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Major hepatectomy in perihilar cholangiocarcinoma (pCCA) patients with a small future liver remnant (FLR) risks posthepatectomy liver failure (PHLF). This study examines combined portal and hepatic vein embolisation (PVE/HVE) to increase preoperative FLR volume and potentially decrease PHLF rates.In this retrospective, multicentre, observational study, data was collected from centres affiliated with the DRAGON Trials Collaborative and the EuroLVD registry. The study included pCCA patients who underwent PVE/HVE between July 2016 and January 2023.Following PVE/HVE, 28% of patients (9/32) experienced complications, with 22% (7/32) necessitating biliary interventions for cholangitis. The median degree of hypertrophy after a median of 16 days was 16% with a kinetic growth rate of 6.8% per week. 69% of patients (22/32) ultimately underwent surgical resection. Cholangitis after PVE/HVE was associated with unresectability. After resection, 55% of patients (12/22) experienced complications, of which 23% (5/22) were Clavien-Dindo grade III or higher. The 90-day mortality after resection was 0%.PVE/HVE quickly enhances the kinetic growth rate in pCCA patients. Cholangitis impairs chances on resection significantly. Resection after PVE/HVE is associated with low levels of 90-day mortality. The study highlights the potential of PVE/HVE in improving safety and outcomes in pCCA undergoing resection. |
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| ISSN: | 1365182X |
| DOI: | 10.1016/j.hpb.2024.07.407 |